Last update :
08/12/2024
Anticancer drug   Methotrexate sodium  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Abitrexate Republic of South Africa
Antifolan Romania
Artrait Argentina
Bendatrexat Germany
Biometrox Brazil
Ebetrex Switzerland
Ebetrexate Austria
Emthexat Turkey
Emthexate Belgium, Netherlands, Republic of South Africa, Spain
Ledertrexate Belgium, France, Luxembourg, Morocco
Maxtrex Great Britain
Metex Germany, Norway
Methoblastin Republic of South Africa
Methotrexamed Germany
Methotrexate France
Metoject Chile, Denmark, Finland, France, Great Britain, Netherlands, Spain, Sweden, Switzerland
Metotrexato Chile
Trexan Finland
Trexat Germany
References   injection   References : Methotrexate sodium  
Type Publication
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Physical and chemical stability of methotrexate sodium, cytarabine, and hydrocortisone sodium succinate in Elliott’s B solution.
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Stability and compatibility of granisetron hydrochloride in IV solutions and oral liquids and during simulated Y-site injection with selected drugs.
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Compatibility of piperacillin sodium plus tazobactam with selected drugs during simulated Y-site injection.
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84 Journal Trissel LA, Martinez JF.
Visual, turbidimetric, and particle-content assessment of compatibility of vinorelbine tartrate with selected drugs during simulated Y-site injection.
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85 Journal Trissel LA, Bready BB.
Turbidimetric assessment of the compatibility of taxol with selected other drugs during simulated Y-site injection.
Am J Hosp Pharm 1992 ; 49: 1716-1719.
91 Journal Lober CA, Dollard PA.
Visual compatibility of gallium nitrate with selected drugs during Y-site injection.
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99 Journal Trissel LA, Martinez JF.
Compatibility of aztreonam with selected drugs during simulated Y-site administration.
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110 Journal Vincke BJ, Verstraeten AE, El Eini DID, Mc Carthy TM.
Extended stability of 5-fluorouracil and methotrexate solutions in PVC containers.
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Photosensibility of 5-fluorouracile and methotrexate in translucent or opaque perfusers.
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150 Journal Aujoulat P, Coze C, Braguer D, Raybaud C.
Physicochemical compatibility of methotrexate with co-administered drugs during cancer chemotherapy regimens.
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Compatibility study of methotrexate with PVC bags after repackaging into two types of infusion admixtures.
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169 Journal Trissel LA, Martinez JF.
Physical compatibility of melphalan with selected drugs during simulated Y-site administration.
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Stability of ondansetron hydrochloride and five antineoplasic medications.
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Compatibility of filgrastim with selected drugs during simulated Y-site administration.
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Compatibility of thiotepa (lyophilized) with selected drugs during simulated Y-site administration.
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251 Journal Trissel LA, Gilbert DL, Martinez JF.
Compatibility of doxorubicin hydrochloride liposome injection with selected other drugs during simulated Y-site administration.
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300 Journal Trissel LA, Gilbert DL, Martinez JF.
Compatibility of propofol injectable emulsion with selected drugs during simulated Y-site administration.
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Compatibility of parenteral nutrient solutions with selected drugs during simulated Y-site administration.
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307 Journal Trissel LA, Martinez JF.
Compatibility of allopurinol sodium with selected drugs during simulated Y-site administration.
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Visual compatibility of hydroxyzine hydrochloride with various antineoplasic agents.
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Visual compatibility of ondansetron hydrochloride with selected drugs during simulated Y-site injection.
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335 Journal Trissel LA, Bready BB, Kwan JW, Santiago NM.
Visual compatibility of sargramostim with selected antineoplasic agents, anti-infectives, or other drugs during simulated Y-site injection.
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431 Journal McRae MP, King JC.
Compatibility of antineoplastic, antibiotic and corticosteroid drugs in intravenous admixtures.
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491 Journal Turowski RC, Durthaler JM.
Visual compatibility of idarubicin hydrochloride with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1991 ; 48: 2181-2184.
492 Journal Trissel LA, Parks NPT, Santiago NM.
Visual compatibility of fludarabine phosphate with antineoplastic drugs, anti-infectives, and other selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1991 ; 48: 2186-2189.
739 Journal Cradock JC, Kleinmann LM, Rahman A.
Evaluation of some pharmaceutical aspects of intrathecal methotrexate sodium, cytarabine and hydrocortisone sodium succinate.
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Drug precipitation within IV tubing : A potential hazard of chemotherapy administration.
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Stability of cytotoxic intravenous solutions subjected to freeze-thaw treatment.
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905 Journal Trissel LA, Martinez JF.
Screening teniposide for Y-site physical incompatibilities.
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921 Journal Trissel LA, Gilbert DL, Martinez JF.
Incompatibility and compatibility of amphotericin B cholesteryl sulfate complex with selected other drugs during simulated Y-site administration.
Hosp Pharm 1998 ; 33: 284-292.
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Methotrexate and cytarabine for intrathecal administration.
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Methotrexate in solutions - A stability test for the hospital pharmacy.
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Stability of cytarabine, methotrexate sodium, and hydrocortisone sodium succinate admixtures.
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1088 Journal Johnston A, McKenzie MA, Krasnow SH, Hood MA, Cohen MH.
Drug trapping in intravenous infusion side arms.
JAMA 1984 ; 252: 2392.
1155 Journal Wright MP, Newton JM.
Stability of methotrexate injection in prefilled plastic disposable syringes.
Int J Pharm 1988 ; 45: 237-244.
1158 Journal McElnay JC, Elliott DS, Cartwright-Shamoon J, D?Arcy PF.
Stability of methotrexate and vinblastine in burette administration sets.
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1410 Journal Trissel LA, Martinez JF, Simmons M.
Compatibility of etoposide phosphate with selected drugs during simulated Y-site injection.
J Am Pharm Assoc 1999 ; 39: 141-145.
1415 Journal Trissel L.A, Gilbert D.L, Martinez J.F, Baker M.B, Walter W.V, Mirtallo J.M.
Compatibility of medications with 3-in-1 parenteral nutrition admixtures.
JPEN 1999 ; 23: 67-74.
1423 Journal Trissel LA, Martinez JF, Gilbert DL.
Compatibility of gemcitabine hyrochloride with 107 selected drugs during simulated Y-site injection.
J Am Pharm Assoc 1999 ; 39: 514-518.
1469 Journal Jacolot A, Arnaud P, Lecompte D, Alamercery S, Caroff E, Naveau C, Guillot T, Bousselet M, Brion F.
Stability and compatibility of 2.5 mg/ml methotrexate solution in plastic syringes over 7 days.
Int J Pharm 1996 ; 128: 283-286.
1501 Journal Beitz C, Bertsch T, Hannak D, Schrammel W, Einberger C, Wehling M.
Compatibility of plastics with cytotoxic drug solutions - comparison of polyethylene with other container materials.
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1520 Manufacturer Etude de stabilité des médicaments en Ecoflac®
B Braun 2001
1625 Journal Trissel LA, Saenz C, Williams YW, Ingram D.
Incompatibilities of lansoprazole injection with other drugs during simulated Y-site coadministration.
Int J Pharm Compound 2001 ; 5: 314-321.
1661 Journal Trissel LA, King KM, Zhang Y, Wood AM.
Physical and chemical stability of methotrexate, cytarabine, and hydrocortisone in Elliott’s B Solution for intrathecal use.
J Oncol Pharm Practice 2002 ; 8: 27-32.
1662 Journal Trissel LA, Saenz CA, Ingram DS, Ogundele AB.
Compatibility screening of oxaliplatin during simulated Y-site administration with other drugs.
J Oncol Pharm Practice 2002 ; 8: 33-37.
1925 Journal Trissel LA , Williams KY, Gilbert DL.
Compatibility screening of linezolid injection during simulated Y-site administration with other drugs and infusion solutions.
J Am Pharm Assoc 2000 ; 40: 515-519.
2262 Journal Brammer MK, Chan P, Heatherly K, Trusley C, Kupiec TC, Trissel LA, Psathas PA, Gilmor T, Schaufelberger D.
Compatibility of doripenem with other drugs during simulated Y-site administratioN
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3275 Journal D'Hondt M, Vangheluwe E, Van Dorpe S, Boonen J, Bauters T, Pelfrene B, Vandenbroucke J, Robays H, De Spiegeleer B
Stability of extemporaneously prepared cytarabine, methotrexate sodium, and methylprednisolone sodium succinate
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3474 Manufacturer Fluorouracil - Summary of Product Characteristics
Accord Healthcare Limited 2009
3580 Manufacturer Cytarabine Accord - Résumé des caractéristiques du produit
Accord Healthcare France 2016
3637 Manufacturer Methotrexate (Methotrexate solution for injection®) - Summary of Product Characteristics
Hameln Pharmaceuticals 2014
3670 Journal Sewell G, Massimini M.
Studies on the stability and compatibility of cytotoxic drug infusion with the Tevadaptor system.
EJOP 2014 ; 8, 3: 26-30.
3731 Journal Chatterji D.C, Gallelli J.F.
Thermal and photolytic decomposition of methotrexate in aqueous solutions.
J Pharm Sci 1978 ; 67, 4: 526-530.
3980 Journal Nissen K.B, Jorgensen L.B, Berg D.L, Andersen G.
Stability study of methotrexate in 0.9% sodium chloride injection and 5% dextrose injection with limit tests for impurities.
Am J Health-Syst Pharm 2017 ; 74,9: e211-e223
4154 Manufacturer Bleomycin sulfate- Summary of Product Characteristics
Accord Health Care 2018
4578 Thesis Respaud R.
Etude de stabilité de médicaments anticancéreux injectables : apports analytiques et pharmaceutiques
2011
4641 Journal Zanon D, Selmin F, Centin G, Maximova N, Casiraghi A, Minghetti P.
Stability of high concentrated triple intrathecal therapy for pediatrics and mitigation strategies.
Eur J Pharm Sci 2021 ;167: 106039.

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