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Analgesic   Nefopam  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Acupan France, Great Britain, Ireland, Italy, Luxembourg, Morocco, North Ireland, Poland, Romania, Tunisia
Nefam Italy
Nefomed Tunisia
Nefopam Egypt, Poland
Nephentil Mexico
Nopain Egypt
Oxadol Italy
Painstop Saudi Arabia
References   injection   References : Nefopam  
Type Publication
2265 Journal Tu YH, Wang DP, Allen LV.
Nefopam hydrochloride degradation kinetics in solution.
J Pharm Sci 1990 ; 79, 1: 48-52.
2311 Journal Kambia N.K, Luyckx M, Dine T, Dupin-Spriet T, Gressier B, Brunet C.
Nefopam hydrochloride compatibility and stability with selected proton pump inhibitors in bionolyte G5 injection for intravenous infusion.
J Clin Pharm Ther 2009 ; 34: 25-31.
3075 Journal Balayssac D, Badaroux L, Rodier C, Sautou-Miranda V, Bazin JE, Chopineau J.
Compatibility and stability of parenteral analgesic admixtures for multimodal analgesia
EJHP Science 2009 ; 15, 4: 78-82.
3728 Journal Correard F, Savry A, Gauthier-Villano L, Pisano P, Pourroy B.
Visual compatibility of defibrotide with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2014 ; 71: 1288-1291.
3791 Poster Sadou Yaye H, Burtet E, Hamel C, Aljhni R, Gard C, Tilleul P.
Étude de la compatibilité physico-chimique du phloroglucinol injectable durant les mélanges au sein des tubulures en Y.
Apifh Congress, Paris November 2014 2014
3976 Journal Du Repaire T, Vigne P, Guedon A, Gauthier-Villano L, Bertault Peres P, Pourroy B.
Visual compatibility of blinatumomab with selected co-administrated drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2017 ; 74,16 : 1217-1218
4254 Journal D'Huart E, Vigneron J, Demoré B.
Physical Compatibility of Intravenous Drugs Commonly Used in Intensive Care Units: An Observational Study and Physical Compatibility Laboratory Tests on Anti-Infective Drugs
Pharmaceutical Technology in Hospital Pharmacy 2019 ;4,1:29-40
4267 Journal D'Huart E, Vigneron J, Clarot I, Demoré B.
Physicochemical stability of nefopam and nefopam/droperidol solutions in polypropylene syringes for intensive care units.
EJHP 2019
4521 Journal Polo C, D’Huart E, Lesperlette G, Vigneron J, Meyer F, Demoré B.
Compatibility of injectable posaconazole with drugs commonly used in a hematology care unit.
Pharmaceutical Technology in Hospital Pharmacy 2020
4666 Journal Lee C.H, Kim A.R, Lee M.K, Oh J.S, Lee D.K, Choi S.S.
Intravenous patient-controlled analgesia: in vitro stability profiles of mixtures containing fentanyl, hydromorphone, oxycodone, nefopam, ondansetron, and ramosetron.
J Anal Sci Tech 2020 ; 11: 32.
4698 Journal Ayari G, D'Huart E, Vigneron J, Demoré B.
Y-site compatibility of intravenous medications commonly used in intensive care units : laboratory tests on 75 mixtures involving nine main drugs.
Pharmaceutical Technology in Hospital Pharmacy 2022
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