Last update :
19/09/2022
References   References 4666  
Type : Journal
Web link : https://doi.org/10.1186/s40543-020-00230-w

Research teams : Séoul - Department of Anesthesiology and Pain Medicine, Korea University Medical Center, Guro Hospital, Seoul , Republic of Korea.
Authors : Lee C.H, Kim A.R, Lee M.K, Oh J.S, Lee D.K, Choi S.S.
Title : Intravenous patient-controlled analgesia: in vitro stability profiles of mixtures containing fentanyl, hydromorphone, oxycodone, nefopam, ondansetron, and ramosetron.
Reference : J Anal Sci Tech ; 11: 32. 2020

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
InjectionFentanyl citrate Analgesic
InjectionHydromorphone hydrochloride Analgesic
InjectionNefopam Analgesic
InjectionOndansetron hydrochloride Antiemetic
InjectionOxycodone hydrochloride Analgesic
InjectionRamosetron Antiemetic
Stability of mixtures
Polyisoprene elastomer Sodium chloride 0,9% 24°C Protect from light
Injection Fentanyl citrate 16 µg/ml
Injection Hydromorphone hydrochloride 0,08 mg/ml
Injection Nefopam 0,8 mg/ml
Injection Ramosetron 12 µg/ml
4 Day
Polyisoprene elastomer Sodium chloride 0,9% 24°C Protect from light
Injection Fentanyl citrate 16 µg/ml
Injection Oxycodone hydrochloride 0,4 mg/ml
Injection Nefopam 0,8 mg/ml
Injection Ondansetron hydrochloride 0,32 mg/ml
4 Day
Polyisoprene elastomer Sodium chloride 0,9% 24°C Protect from light
Injection Fentanyl citrate 16 µg/ml
Injection Oxycodone hydrochloride 0,4 mg/ml
Injection Nefopam 0,8 mg/ml
Injection Ramosetron 12 µg/ml
4 Day
Polyisoprene elastomer Sodium chloride 0,9% 24°C Protect from light
Injection Fentanyl citrate 16 µg/ml
Injection Hydromorphone hydrochloride 0,08 mg/ml
Injection Nefopam 0,8 mg/ml
Injection Ondansetron hydrochloride 0,32 mg/ml
4 Day

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