Last update :
19/11/2024
Anticancer drug   Pemetrexed disodium  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Alimta Argentina, Australia, Austria, Belgium, Brazil, Canada, Chile, Colombia, Denmark, Ecuador, Finland, France, Germany, Great Britain, Greece, Hungary, Iceland, Ireland, Italy, Japan, Luxembourg, Malaysia, Mexico, Morocco, Netherlands, New Zealand, Norway, Peru, Poland, Portugal, Romania, Saudi Arabia, Spain, Sweden, Switzerland, Tunisia, Turkey, United Arab Emirates, United States of America, Venezuela
Alltrexed Argentina
Amtiris Switzerland
Armisarte
Ekel Argentina
Enzastar Argentina
Holista Argentina
Lidoras Argentina, Ecuador
Martxel Argentina
Pamifect India
Pemetrexed Argentina, Peru, Romania, Switzerland
Pemtrex Turkey
Peymetrel Argentina
Praxed Argentina
Prexed Turkey
Sukuba Argentina
Trexam Argentina
Trextech Argentina
Trixid Romania
Utrexed Argentina
Venusted Argentina
Compatibility   injection   Compatibility : Pemetrexed disodium              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Unspecified incompatibility Incompatible
injection Pemetrexed disodium
Ringer’s lactate solution 1914
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Aciclovir sodium 7 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Amifostine 10 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Amikacin sulfate 5 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Aminophylline 2.5 mg/ml
Sodium chloride 0,9% 1953
Immediate precipitation Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Amphotericin B 0.6 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Ampicillin sodium 20 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Ampicillin sodium - sulbactam sodium 20/10 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Aztreonam 40 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Bumetanide 0.04 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Buprenorphine hydrochloride 0.04 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Butorphanol tartrate 0.04 mg/ml
Sodium chloride 0,9% 1953
Unspecified incompatibility Incompatible
injection Pemetrexed disodium
injection Calcium chloride
1914
Unspecified incompatibility Incompatible
injection Pemetrexed disodium
injection Calcium glucoheptonate
1914
Precipitation after 4 hours Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Calcium gluconate 40 mg/ml
Sodium chloride 0,9% 1953
Unspecified incompatibility Incompatible
injection Pemetrexed disodium
injection Calcium gluconate
1914
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Carboplatin 5 mg/ml
Sodium chloride 0,9% 1953
Color change after 4 hours Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Cefazolin sodium 20 mg/ml
Sodium chloride 0,9% 1953
Color change after 4 hours Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Cefotaxime sodium 20 mg/ml
Sodium chloride 0,9% 1953
Color change Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Cefoxitin sodium 20 mg/ml
Sodium chloride 0,9% 1953
Color change after 4 hours Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Ceftazidime 40 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Ceftizoxime sodium 20 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Ceftriaxone disodium 20 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Cefuroxime sodium 30 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Cimetidine hydrochloride 12 mg/ml
Sodium chloride 0,9% 1953
Color change after 4 hours Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Ciprofloxacin lactate 2 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Cisplatin 0.5 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Clindamycin phosphate 10 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Co-trimoxazole 0.8/4 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Cyclophosphamide 10 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Cytarabine 50 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Dexamethasone sodium phosphate 1 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Dexrazoxane hydrochloride 5 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Diphenhydramine hydrochloride 2 mg/ml
Sodium chloride 0,9% 1953
Immediate precipitation Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Dobutamine hydrochloride 4 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Docetaxel 0.8 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Dopamine hydrochloride 3.2 mg/ml
Sodium chloride 0,9% 1953
Color change Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Doxorubicin hydrochloride 1 mg/ml
Sodium chloride 0,9% 1953
Immediate precipitation Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Doxycycline hyclate 1 mg/ml
Sodium chloride 0,9% 1953
Immediate precipitation Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Droperidol 2.5 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Enalaprilate 0.1 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Famotidine 2 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Fluconazole 2 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Fluorouracil 16 mg/ml
Sodium chloride 0,9% 1953
Unspecified incompatibility Incompatible
injection Pemetrexed disodium
injection Folinate calcium
1914
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Folinate calcium 2 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Ganciclovir sodium 20 mg/ml
Sodium chloride 0,9% 1953
Immediate precipitation Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Gemcitabine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1953
Immediate precipitation Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Gentamicin sulfate 5 mg/ml
1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Granisetron hydrochloride 0.05 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Haloperidol lactate 0.2 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Heparin sodium 100 UI/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Hydromorphone hydrochloride 0.5 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Hydroxyzine dihydrochloride 2 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Ifosfamide 20 mg/ml
Sodium chloride 0,9% 1953
Color change after 4 hours Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Irinotecan 1 mg/ml
Sodium chloride 0,9% 1953
Unspecified incompatibility Incompatible
injection Pemetrexed disodium
injection Levofolinate calcium
1914
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Lorazepam 0.5 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Mannitol 150 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Mesna 10 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Methylprednisolone sodium succinate 5 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Metoclopramide hydrochloride 5 mg/ml
Sodium chloride 0,9% 1953
Color change Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Metronidazole 5 mg/ml
Sodium chloride 0,9% 1953
Color change after 4 hours Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Minocycline hydrochloride 0.2 mg/ml
Sodium chloride 0,9% 1953
Immediate precipitation Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Mitoxantrone dihydrochloride 0.5 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Morphine sulfate 15 mg/ml
Sodium chloride 0,9% 1953
Immediate precipitation Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Nalbuphine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1953
Immediate precipitation Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Ondansetron hydrochloride 1 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Paclitaxel 0.6 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Pethidine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Potassium chloride 100 mEq/l
Sodium chloride 0,9% 1953
Immediate precipitation Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Prochlorperazine edysilate 0.5 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Promethazine hydrochloride 2 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Ranitidine hydrochloride 2 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Sodium bicarbonate 84 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Ticarcillin / clavulanic acid 31 mg/ml
Sodium chloride 0,9% 1953
Immediate precipitation Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Tobramycin sulfate 5 mg/ml
Sodium chloride 0,9% 1953
Color change Incompatible
injection Pemetrexed disodium 20 mg/ml
injection Topotecan 0.1 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Vancomycin hydrochloride 10 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Vinblastine sulfate 0.12 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Vincristine sulfate 0.05 mg/ml
Sodium chloride 0,9% 1953
Compatible
injection Pemetrexed disodium 20 mg/ml
injection Zidovudine 4 mg/ml
Sodium chloride 0,9% 1953

  Mentions Légales