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Antiemetic   Ondansetron hydrochloride  
injection
Oral solution
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Amal Mexico
Ansentron Brazil
Antivon Chile, Mexico
Atossa Poland
Avessaron Belgium
Axisetron Germany
Bryterol Colombia, Ecuador
Cellondan Germany
Chemoset Morocco
Danac Mexico
Danofran Egypt
Danset Egypt
Dantron Morocco, Republic of South Africa
Dasentron Argentina, Saudi Arabia
Dismolan Argentina, Venezuela
Donset India
Emeset India, Romania, Turkey
Emetron Hungary, Poland
Emistop Mexico, Peru
Indansen Mexico
Nausetron Republic of South Africa
Ondansan Austria
Ondatron Germany
Setronon Croatia
Vomiz Republic of South Africa
Yatrox Spain
Zofer Turkey
Zofran Argentina, Austria, Belgium, Canada, Colombia, Denmark, Ecuador, Egypt, Finland, Germany, Great Britain, Hungary, Iceland, Ireland, Italy, Luxembourg, Malaysia, Morocco, Netherlands, New Zealand, Norway, Peru, Poland, Portugal, Saudi Arabia, Sweden, Switzerland, Turkey, United Arab Emirates, United States of America
Zofron Greece
Zontron Turkey
Zophren France, Tunisia
Zotrix Sweden
Stability of mixtures   injection   Stability of mixtures : Ondansetron hydrochloride     
Container Solvent Concentration Compound Temperature Storage Duration of stability References
Glass NaCl 0,9% or Glucose 5% 0,14 & 0,45 mg/ml
injection   Ondansetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,34 mg/ml
25°C
24 Hour
Light 25
Glass Sodium chloride 0,9% 0,015 >> 0,15 mg/ml
injection   Ondansetron hydrochloride   
injection   Piperacillin sodium / tazobactam 20/2,5 >> 40/5 mg/ml
23°C
4 Hour
Light 16
Glass Glucose 5% 0,03 & 0,3 mg/ml
injection   Ondansetron hydrochloride   
injection   Paclitaxel 0,3 & 1,2 mg/ml
23°C
4 Hour
Light 47
Level of evidence A
Glass Glucose 5% 0,3 mg/ml
injection   Ondansetron hydrochloride   
injection   Paclitaxel 1,2 mg/ml
injection   Ranitidine hydrochloride 2,0 mg/ml
23°C
4 Hour
Light 47
Level of evidence A
Glass Glucose 5% 0,03 & 0,3 mg/ml
injection   Ondansetron hydrochloride   
injection   Ranitidine hydrochloride 0,5 & 2 mg/ml
25°C
4 Hour
Light 18
Level of evidence A
Glass Glucose 5% 0,44 mg/ml
injection   Ondansetron hydrochloride   
injection   Lorazepam 0,028 mg/ml
injection   Dexamethasone sodium phosphate 0,28 mg/ml
25°C
24 Hour
Light 25
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,15 mg/ml
injection   Ondansetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,43 mg/ml
15-25°C
28 Day
Protect from light 23
Level of evidence A
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,15 mg/ml
injection   Ondansetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,43 mg/ml
2-8°C
28 Day
Protect from light 23
Level of evidence A
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,05 mg/ml
injection   Ondansetron hydrochloride   
injection   Cyclophosphamide 0,3 mg/ml
23°C-25°C
4 Day
Light 50
Level of evidence B
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,4 mg/ml
injection   Ondansetron hydrochloride   
injection   Cyclophosphamide 2 mg/ml
23°C-25°C
4 Day
Light 50
Level of evidence B
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,14 & 0,45 mg/ml
injection   Ondansetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,28 mg/ml
25°C
24 Hour
Light 25
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,05 mg/ml
injection   Ondansetron hydrochloride   
injection   Cyclophosphamide 0,3 mg/ml
4°C
8 Day
Light 50
Level of evidence B
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,4 mg/ml
injection   Ondansetron hydrochloride   
injection   Cyclophosphamide 2 mg/ml
4°C
8 Day
Light 50
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 0,1 >> 0,4 mg/ml
injection   Ondansetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,02 & 0,4 mg/ml
2-6°C
30 Day
Protect from light 30
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 0,1 >> 0,64 mg/ml
injection   Ondansetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,2 & 0,4 mg/ml
2-6°C
30 Day
Protect from light 30
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 1,091 mg/ml
injection   Ondansetron hydrochloride   
injection   Cisplatin 0,455 mg/ml
2-8°C
24 Hour
Protect from light 53
Level of evidence C
Polyvinyl chloride Sodium chloride 0,9% 0,1 & 1 mg/ml
injection   Ondansetron hydrochloride   
injection   Pethidine hydrochloride 4 mg/ml
22°C
31 Day
Not specified 332
Level of evidence A+
Polyvinyl chloride Sodium chloride 0,9% 0,1 & 1 mg/ml
injection   Ondansetron hydrochloride   
injection   Hydromorphone hydrochloride 0,5 mg/ml
22°C
31 Day
Not specified 6
Level of evidence A+
Polyvinyl chloride Sodium chloride 0,9% 0,1 & 1 mg/ml
injection   Ondansetron hydrochloride   
injection   Morphine sulfate 1 mg/ml
22°C
31 Hour
Not specified 6
Level of evidence A+
Polyvinyl chloride Sodium chloride 0,9% 0,1 >> 0,4 mg/ml
injection   Ondansetron hydrochloride   
injection   Dexamethasone sodium phosphate 0.2 & 0.4 mg/ml
22°C-23°C
48 Hour
Protect from light 30
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 0,1 >> 0,64 mg/ml
injection   Ondansetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,2 & 0,4 mg/ml
22°C-23°C
48 Hour
Protect from light 30
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 1,091 mg/ml
injection   Ondansetron hydrochloride   
injection   Cisplatin 0,455 mg/ml
30°C
168 Hour
Protect from light 53
Level of evidence C
Polyvinyl chloride Sodium chloride 0,9% 0,96 mg/ml
injection   Ondansetron hydrochloride   
injection   Doxorubicin hydrochloride 0,8 mg/ml
injection   Vincristine sulfate 0,028 mg/ml
30°C
5 Day
Not specified 26
Level of evidence D
Polyvinyl chloride Sodium chloride 0,9% 0,1 & 1 mg/ml
injection   Ondansetron hydrochloride   
injection   Hydromorphone hydrochloride 0,5 mg/ml
32°C
7 Day
Not specified 6
Level of evidence A+
Polyvinyl chloride Sodium chloride 0,9% 0,1 & 1 mg/ml
injection   Ondansetron hydrochloride   
injection   Pethidine hydrochloride 4 mg/ml
32°C
7 Day
Not specified 332
Level of evidence A+
Polyvinyl chloride Sodium chloride 0,9% 0,1 & 1 mg/ml
injection   Ondansetron hydrochloride   
injection   Morphine sulfate 1 mg/ml
32°C
7 Hour
Not specified 6
Level of evidence A+
Polyvinyl chloride Sodium chloride 0,9% 0,1 & 1 mg/ml
injection   Ondansetron hydrochloride   
injection   Hydromorphone hydrochloride 0,5 mg/ml
4°C
31 Day
Protect from light 6
Level of evidence A+
Polyvinyl chloride Sodium chloride 0,9% 0,1 & 1 mg/ml
injection   Ondansetron hydrochloride   
injection   Pethidine hydrochloride 4 mg/ml
4°C
31 Day
Protect from light 332
Level of evidence A+
Polyvinyl chloride Sodium chloride 0,9% 0,1 & 1 mg/ml
injection   Ondansetron hydrochloride   
injection   Morphine sulfate 1 mg/ml
4°C
31 Hour
Protect from light 6
Level of evidence A+
Polyvinyl chloride Sodium chloride 0,9% 0,1 & 1 mg/ml
injection   Ondansetron hydrochloride   
injection   Hydromorphone hydrochloride 0,5 mg/ml
4°C-22°C
31 Day
Not specified 6
Level of evidence A+
Polyvinyl chloride Glucose 5% 0,03 & 0,3 mg/ml
injection   Ondansetron hydrochloride   
injection   Cytarabine 0,2 & 40 mg/ml
21°C-23°C
48 Hour
Light 184
Level of evidence C+
Polyvinyl chloride Glucose 5% 0,03 & 0,3 mg/ml
injection   Ondansetron hydrochloride   
injection   Doxorubicin hydrochloride 0,1 & 2 mg/ml
21°C-23°C
48 Hour
Light 184
Level of evidence C+
Polyvinyl chloride Glucose 5% 0,03 & 0,3 mg/ml
injection   Ondansetron hydrochloride   
injection   Etoposide 0,1 & 0,4 mg/ml
21°C-23°C
48 Hour
Light 184
Level of evidence C+
Polyvinyl chloride Glucose 5% 0,03 & 0,3 mg/ml
injection   Ondansetron hydrochloride   
injection   Methotrexate sodium 0,5 & 6 mg/ml
21°C-23°C
48 Hour
Light 184
Level of evidence C+
Polyvinyl chloride Glucose 5% 0,64 mg/ml
injection   Ondansetron hydrochloride   
injection   Dacarbazine 8 mg/ml
injection   Doxorubicin hydrochloride 0,8 mg/ml
30°C
24 Hour
Not specified 26
Level of evidence D
Polyvinyl chloride Glucose 5% 0,64 mg/ml
injection   Ondansetron hydrochloride   
injection   Dacarbazine 8 mg/ml
injection   Doxorubicin hydrochloride 0,8 mg/ml
4°C
7 Day
Protect from light 26
Level of evidence D
Polyethylene Glucose 5% 0,09 mg/ml
injection   Ondansetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,09 mg/ml
- 20°C
90 Day
Protect from light 3174
Polyethylene Glucose 5% 0,09 mg/ml
injection   Ondansetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,09 mg/ml
2-8°C
90 Day
Not specified 3174
Polypropylene Sodium chloride 0,9% 1,33 mg/ml
injection   Ondansetron hydrochloride   
injection   Neostigmine methylsulfate 0.167 mg/ml
23°C
24 Hour
Protect from light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1,33 mg/ml
injection   Ondansetron hydrochloride   
injection   Naloxone hydrochloride 0,133 mg/ml
23°C
24 Hour
Light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1,33 mg/ml
injection   Ondansetron hydrochloride   
injection   Midazolam hydrochloride 1,66 mg/ml
23°C
24 Hour
Light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1,33 mg/ml
injection   Ondansetron hydrochloride   
injection   Alfentanil hydrochloride 167 µg/ml
23°C
24 Hour
Light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1,33 mg/ml
injection   Ondansetron hydrochloride   
injection   Atropine sulfate 0,133 mg/ml
23°C
24 Hour
Light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1,33 mg/ml
injection   Ondansetron hydrochloride   
injection   Morphine sulfate 2,67 mg/ml
23°C
24 Hour
Light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1,33 mg/ml
injection   Ondansetron hydrochloride   
injection   Pethidine hydrochloride 8,33 mg/ml
23°C
24 Hour
Light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1 mg/ml
injection   Ondansetron hydrochloride   
injection   Propofol 1 & 5 mg/ml
23°C
24 Hour
Light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1 mg/ml
injection   Ondansetron hydrochloride   
injection   Glycopyrronium bromide 0,1 mg/ml
23°C
24 Hour
Light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1,33 mg/ml
injection   Ondansetron hydrochloride   
injection   Naloxone hydrochloride 0,133 mg/ml
4°C
24 Hour
Protect from light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1,33 mg/ml
injection   Ondansetron hydrochloride   
injection   Midazolam hydrochloride 1,66 mg/ml
4°C
24 Hour
Protect from light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1,33 mg/ml
injection   Ondansetron hydrochloride   
injection   Alfentanil hydrochloride 167 µg/ml
4°C
24 Hour
Protect from light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1,33 mg/ml
injection   Ondansetron hydrochloride   
injection   Atropine sulfate 0,133 mg/ml
4°C
24 Hour
Protect from light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1,33 mg/ml
injection   Ondansetron hydrochloride   
injection   Morphine sulfate 2,67 mg/ml
4°C
24 Hour
Protect from light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1,33 mg/ml
injection   Ondansetron hydrochloride   
injection   Pethidine hydrochloride 8,33 mg/ml
4°C
24 Hour
Protect from light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1 mg/ml
injection   Ondansetron hydrochloride   
injection   Glycopyrronium bromide 0,1 mg/ml
4°C
24 Hour
Protect from light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1,33 mg/ml
injection   Ondansetron hydrochloride   
injection   Neostigmine methylsulfate 0.167 mg/ml
4°C
24 Hour
Protect from light 815
Level of evidence C+
Polyolefine NaCl 0,9% or Glucose 5% 0,16 mg/ml
injection   Ondansetron hydrochloride   
injection   Methylprednisolone sodium succinate 2,4 mg/ml
20°C-25°C
24 Hour
Light 2012
Polyolefine NaCl 0,9% or Glucose 5% 0,08 mg/ml
injection   Ondansetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,1 mg/ml
23-27°C
48 Hour
Light 3981
Level of evidence A+
Polyolefine NaCl 0,9% or Glucose 5% 0,08 mg/ml
injection   Ondansetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,2 mg/ml
23-27°C
48 Hour
Light 3981
Level of evidence A+
Polyolefine NaCl 0,9% or Glucose 5% 0,16 mg/ml
injection   Ondansetron hydrochloride   
injection   Methylprednisolone sodium succinate 2,4 mg/ml
4°C
48 Hour
Not specified 2012
Polyolefine Sodium chloride 0,9% 0.08 mg/ml
injection   Ondansetron hydrochloride   
injection   Dexamethasone sodium phosphate 0.1 mg/ml
2-8°C
30 Day
Not specified 3925
Level of evidence A+
Polyolefine Sodium chloride 0,9% 0,074 mg/ml
injection   Ondansetron hydrochloride   
injection   Alizapride hydrochloride 0,926 mg/ml
2-8°C
56 Day
Not specified 4479
Level of evidence D
Polyolefine Sodium chloride 0,9% 0,08 mg/ml
injection   Ondansetron hydrochloride   
injection   Tramadol hydrochloride 10 mg/ml
25°C
14 Day
Not specified 4116
Level of evidence A
Polyolefine Sodium chloride 0,9% 0,08 mg/ml
injection   Ondansetron hydrochloride   
injection   Tramadol hydrochloride 10 mg/ml
4°C
14 Day
Not specified 4116
Level of evidence A
Polypropylen Syringe Water for Injection 2 mg/ml
injection   Ondansetron hydrochloride   
injection   Paracetamol 10 mg/ml
25°C
4 Hour
Not specified 3571
Level of evidence A+
Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml
injection   Ondansetron hydrochloride   
injection   Droperidol 1,25 mg/ml
23°C
8 Hour
Light 815
Level of evidence C+
Polypropylen Syringe Sodium chloride 0,9% 1,33 mg/ml
injection   Ondansetron hydrochloride   
injection   Fentanyl citrate 16,7 µg/ml
23°C
24 Hour
Light 815
Level of evidence C+
Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml
injection   Ondansetron hydrochloride   
injection   Metoclopramide hydrochloride 2,5 mg/ml
23°C
24 Hour
Light 815
Level of evidence C+
Polypropylen Syringe Sodium chloride 0,9% 1,33 mg/ml
injection   Ondansetron hydrochloride   
injection   Fentanyl citrate 16,7 µg/ml
4°C
24 Hour
Protect from light 815
Level of evidence C+
Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml
injection   Ondansetron hydrochloride   
injection   Metoclopramide hydrochloride 2,5 mg/ml
4°C
24 Hour
Protect from light 815
Level of evidence C+
Polyisoprene elastomer Sodium chloride 0,9% 0,32 mg/ml
injection   Ondansetron hydrochloride   
injection   Fentanyl citrate 16 µg/ml
injection   Oxycodone hydrochloride 0,4 mg/ml
injection   Nefopam 0,8 mg/ml
24°C
4 Day
Protect from light 4666
Level of evidence D
Polyisoprene elastomer Sodium chloride 0,9% 0,32 mg/ml
injection   Ondansetron hydrochloride   
injection   Fentanyl citrate 16 µg/ml
injection   Hydromorphone hydrochloride 0,08 mg/ml
injection   Nefopam 0,8 mg/ml
24°C
4 Day
Protect from light 4666
Level of evidence D
Not specified NaCl 0,9% or Glucose 5% 0,24 mg/ml
injection   Ondansetron hydrochloride   
injection   Topotecan 0,028 mg/ml
20°C-23°C
4 Hour
Light 1026
Level of evidence C
  Mentions Légales