Dernière mise à jour :
27/11/2024
Antalgique   Morphine hydrochloride  
injectable
Forme dermique
Stabilité des solutions Stabilité en mélange Facteur influençant la stabilité Compatibilités Voie d’administration Bibliographie pdf
   Structure chimique  

Noms commerciaux   Noms commerciaux     

Les noms commerciaux sont donnés à titre indicatif et la composition en excipients peut être différente selon les pays et selon les laboratoires

Amidiaz Argentine
Analfin Mexique
Morfin Norvège, Suède
Morfina clorhidrato Chili, Equateur, Italie, Pérou
Morfine Pays bas
Morphin Finlande
Morphine Belgique, France
Stellorphine Belgique
Vendal Autriche
Bibliographie   injectable   Bibliographie : Morphine hydrochloride  
Type Source
186 Revue Swart EL, Mooren RAG, Van Loenen AC.
Compatibility of midazolam hydrochloride and lorazepam with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1995 ; 52: 2020-2022.
219 Revue Oustric-Mendes AC, Huart B, Le Hoang MD, Perrin-Rosset M, Pailler FM, Darbord JC, Prognon, Gard C, Pradeau D.
Study protocol : stability of morphine injected without preservative, delivered with a disposable infusion device.
J Clin Pharm Ther 1997 ; 22: 283-290.
346 Revue Wulf H, Gleim M, Mignat C.
The stability of mixtures of morphine hydrochloride, bupivacaine hydrochloride, and clonidine hydrochloride in portable pump reservoirs for the management of chronic pain syndromes.
J Pain Symptom Manage 1994 ; 9: 308-311.
515 Revue Le Hoang MD, Sarbach C, Prognon P, Delvordre P, Mignot A, Pradeau D.
Stability of morphine hydrochloride solutions in portable single-use PCA systems. Additives leaching into the morphine solutions.
J Pharm Clin 1998 ; 17: 35-39.
679 Revue Roos PJ, Glerum JH, Meilink JW.
Stability of morphine hydrochloride in a portable pump reservoir.
Pharm Weekbl [Sci] 1992 ; 14: 23-26.
1062 Revue Vermeire A, Remon JP.
The stability of morphine and the stability of concentrated morphine solutions in glass, polypropylene syringes and PVC containers.
Int J Pharm 1997 ; 146: 213-223.
1228 Revue Allen LV, Stiles ML.
Compatibility of various admixtures at Y-injection sites of intravenous administration sets. Part2.
Am J Hosp Pharm 1981 ; 38: 380-381.
1264 Revue Truelle-Hugon B, Tourette G, Couineaux B, Gache-Charrette C.
Study of Lavoisier morphine chlorhydrate in different active perfusion systems after reconstitution in different solvents.
Ann Pharm Fr 1997 ; 55: 216-223.
1506 Revue Lopez-Cabezas C, Guerrero L, Molas G, Anglada H, Soy D.
Physicochemical compatibility of high concentration drugs usually Y-site administered in intensive care units.
EJHP 2015 ;22:107-112.
1508 Revue Voirol P, Berger-Gryllaki M, Pannatier A, Eggimann P, Sadeghipour F.
Visual compatibility of insulin aspart with intravenous drugs frequently used in ICU.
EJHP 2015 ;22:123-124.
1513 Laboratoire Quinupristine / dalfopristine (Synercid®) - Résumé des caractéristiques du produit
Monarch Pharmaceuticals Ireland 2006
1757 Revue Schrijvers D, Tai-Apin C, De Smet MC, Cornil P, Vermorken JB, Bruyneel P.
Determination of compatibility and stability of drugs used in palliative care.
J Clin Pharm Ther 1998 ; 23: 311-314.
1842 Revue Sadjack A, Wintersteiger R.
Compatibility of morphin, baclofen, floxuridine and fluorouracil in an implantable infusion pump.
Arzneimittel Forschung 1995 ; 45: 93-98.
1866 Revue Vermeire A, Remon JP.
Compatibility and stability of morphine in binary admixtures with haloperidol, midazolam, dexamethasone or methylprednisolone.
Int J Pharm 1998 ; 174: 157-177.
1885 Revue Essink-Tjebbes CM, Burger DM, Beelen, Wuis EW, Heckster YA.
Long-term stability of morphine and bupivacaine mixture for spinal use.
Pharm World Sci 1999 ; 21: 144-146.
1966 Revue Barcia E, Reyes R, Azuara L, Sànchez Y, Negro S.
Stability and compatibility of binary mixtures of morphine hydrochloride with hyoscine-n-butyl bromide.
Support Care Cancer 2005 ; 13, 4: 239-245.
1971 Revue Azuara ML, Sanchez Y, Reyes R, Barcia E.
Physical compatibility and in vivo evaluation of drug mixtures forsubcutaneous infusion to cancer patients in palliative care.
Support Care Cancer 2001
2055 Revue Negro S, Reyes R, Azuara ML, Sanchez Y, Barcia E.
Morphine, haloperidol and hyoscine N-butyl bromide combined in sc infusion solutions : compatibility and stability evaluation in terminal oncology patients.
Int J Pharm 2006 ; 307: 278-284.
2262 Revue Brammer MK, Chan P, Heatherly K, Trusley C, Kupiec TC, Trissel LA, Psathas PA, Gilmor T, Schaufelberger D.
Compatibility of doripenem with other drugs during simulated Y-site administratioN
Am J Health-Syst Pharm 2008 ; 65: 1261-1265.
2362 Poster Trittler R, M?ller S, Esteban M.
Morphin-Haloperidol mischungen in PCA Pumpen : Kompatibel?
ADKA Congress 2009 2009
2363 Poster M?ller S, Trittler R, Schubert R, von Hornstein W.F, Strehl E.
Morphin-Metamizol mischungen zur kontinuierlichen parenteralen applikation : Sind sie immer inkompatibel?
ADKA Congress 2006
3169 Revue Raffaeli W, Pari G, Visani L et al.
Experimentation about precipitation of pharmacological association: morphine and ketorolac.
Pain Clinic 1999 ; 11: 213-216.
3332 Laboratoire Tigecycline (Tigacyl®) - Summary of Product characteristics
Pfizer 2012
3415 Revue d?Hayer B, Vieillard V, Astier A, Paul M
Stability-Indicating HPLC Assay and Stability Study Over Two Years of Morphine Hydrochloride Diluted Solutions in Polypropylene Syringes
Pharmaceut Anal Acta 2013 ; 4: 205
3470 Revue Destro M, Ottolini L, Vicentini L, Boschetti S.
Physical compatibility of binary and tertiary mixtures of morphine and methadone with other drugs for parenteral administration in palliative care.
Support Care Cancer 2012 ; 20: 2501-2509.
3474 Laboratoire Fluorouracil - Summary of Product Characteristics
Accord Healthcare Limited 2009
3504 Laboratoire Parecoxib (Dynastat®) - Summary of Product Characteristics
Pfizer 2012
3572 Revue Hecq J-D, Godet M, Gillet P, Jamart J, Galanti L.
Long-term Stability of Morphine Hydrochloride in 0.9% NaCl Infusion Polyolefin Bags After Freeze-thaw Treatment and in Polypropylene Syringes at 5°C ± 3°C.
Int J Pharm Compound 2014 ; 18, 1 : 78-82.
3675 Laboratoire Thiopental sodium - Summary of Product Characteristics
Archimedes Pharma UK Ltd 2015
3791 Poster Sadou Yaye H, Burtet E, Hamel C, Aljhni R, Gard C, Tilleul P.
Étude de la compatibilité physico-chimique du phloroglucinol injectable durant les mélanges au sein des tubulures en Y.
Apifh Congress, Paris November 2014 2014
3934 Laboratoire Eptifibatide (Integrilin®) - Résumé des caractéristiques du produit
GlaxoSmithKline Laboratoire 2016
3976 Revue Du Repaire T, Vigne P, Guedon A, Gauthier-Villano L, Bertault Peres P, Pourroy B.
Visual compatibility of blinatumomab with selected co-administrated drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2017 ; 74,16 : 1217-1218
4034 Revue Chen F-C, Fang B-X, Li P, Zheng F, Shi X-Y.
Compatibility and stability of lornoxicam with morphine, tramadol or fentanyl in infusion solutions.
Afr J Pharm Pharmacol 2012 ;27,6:2055-2060
4051 Revue Robert J, Sorrieul J, Kieffer H, Folliard C, Gibory V, Dupoiron D, Devys C.
Stability study of morphine and baclofen solution in polypropylene syringes.
Pharmaceutical Technology in Hospital Pharmacy 2017 ;2,4:173-180
4332 Poster Compatibilité de Glycophos® avec d’autres médicaments administrés en perfusion aux soins intensifs (SI)
Compatibilité de Glycophos® avec d’autres médicaments administrés en perfusion aux soins intensifs (SI).
JFSPH 2019 2019
4404 Poster Müller U, Haller F, Wiedemeier P, Steuer C.
Compatibility studies of seven commonly used drugs for parenteral administration in palliative care.
JFSPH 2019 2019
4538 Revue Campbell A, Petrovski M, Senarathna G, Mukadam ,Strunk T, Batty K.
Compatibility of pentoxifylline and parenteral medications.
Archives of Disease in Childhood 2020 ; 105: 395-397.
4543 Revue Senarathna G, Strunk T, Petrovski M, Batty K.
Physical compatibility of pentoxifylline and intravenous medications.
Archives of Disease in Childhood 2018 ;104:292–295.
4545 Revue Kondo M, Nagano M, Yoshida M, Yoshida N, Tagui N, Yoshida M, Sugaya K, Takase H.
Physical compatibility of nafamostat with analgesics, sedatives, and muscle relaxants for coronavirus disease treatment.
Journal of Nippon Medical school 2021
4643 Revue Catry E, Colsoul M-L, Closset M, Nyssen C, Hubert J, Soumoy L, Bihin B, Jamart J, Hecq J-D, Galanti L.
Evaluation of 30-day stability of morphine hydrochloride and clonidine at high and low concentrations in polypropylene syringes.
EJHP 2021
4651 Revue De Basagoiti A, Katsumiti A, Abascal S, Bustinza A, López-Giménez L.R, Pascual P, De Miguel M, Campino A.
Physical compatibility of alprostadil with selected drugs commonly used in the neonatal intensive care units.
Eur J Pedia 2021 ;180,1169–1176.
4664 Revue Harder M, Fiegl-Lechner A, Oberacher H, Horvath U.E.I, Schlager A, Jeske M, Kerndler S, Schüllner F, Bonn G.F, Rainer M.
Stability evaluation of morphine, hydromorphone, metamizole and esketamine containing analgesic mixtures applied for patient-controlled analgesia in hospice and palliative care.
Biomed Chromatogr 2022 ;e5340.
4667 Revue Ping L, juan H, Li R-L, Feng Z-Y, Zhou X-J, Liu M-F, Jing B, Jian L.
Stability of Hydromorphone Hydrochloride and Morphine under Different Clinical Infusion Conditions.
Int J Pharm Pharm Sci 2019 ;81(6):1140-114
4768 Revue Kondo M, Genpei M, Watanabe K, Yoshida M, Tagui N, Fukao S, Sugaya K, Takase H.
Y-site injection physical compatibility of remdesivr with select intravenous drugs used in palliative care and for treating coronavirus disease 2019.
Journal of Nippon Medical school 2023
4831 Revue Nezvalova-Henriksen K, Huseby Holm T, Nilsson N, Kjønniksen I, Tho I.
Frequently acquired drugs in neonatal intensive care and their physical compatibility.
Acta Paediatr 2022 ;111:2307–2314. 
4832 Revue Nilsson N, Storesund I, Tho I, Nezvalova‑Henriksen K.
Co‑administration of drugs with parenteral nutrition in the neonatal intensive care unit—physical compatibility between three components.
Eur J Pedia 2022 ; 181:2685–2693.
4837 Revue De Silva, D.T.N Petrovski M, Strunk T, Mukadam N, Page‑Sharp N, Moore B.R, Batty K.T.
Physicochemical compatibility of caffeine citrate and caffeine base injections with parenteral medications used in neonatal intensive care settings.
Eur J Clin Pharmacol 2024 ; 80:1079–1087.

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