Monographie - Morphine hydrochloride

Morphine hydrochloride

Chemical structure

Tradename

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Amidiaz	Argentina
Analfin	Mexico
Morfin	Norway, Sweden
Morfina clorhidrato	Chile, Ecuador, Italy, Peru
Morfine	Netherlands
Morphin	Finland
Morphine	Belgium, France
Stellorphine	Belgium
Vendal	Austria

References : Morphine hydrochloride

	Type	Publication
186	Journal	Swart EL, Mooren RAG, Van Loenen AC. Compatibility of midazolam hydrochloride and lorazepam with selected drugs during simulated Y-site administration. Am J Health-Syst Pharm 1995 ; 52: 2020-2022.
219	Journal	Oustric-Mendes AC, Huart B, Le Hoang MD, Perrin-Rosset M, Pailler FM, Darbord JC, Prognon, Gard C, Pradeau D. Study protocol : stability of morphine injected without preservative, delivered with a disposable infusion device. J Clin Pharm Ther 1997 ; 22: 283-290.
346	Journal	Wulf H, Gleim M, Mignat C. The stability of mixtures of morphine hydrochloride, bupivacaine hydrochloride, and clonidine hydrochloride in portable pump reservoirs for the management of chronic pain syndromes. J Pain Symptom Manage 1994 ; 9: 308-311.
515	Journal	Le Hoang MD, Sarbach C, Prognon P, Delvordre P, Mignot A, Pradeau D. Stability of morphine hydrochloride solutions in portable single-use PCA systems. Additives leaching into the morphine solutions. J Pharm Clin 1998 ; 17: 35-39.
679	Journal	Roos PJ, Glerum JH, Meilink JW. Stability of morphine hydrochloride in a portable pump reservoir. Pharm Weekbl [Sci] 1992 ; 14: 23-26.
1062	Journal	Vermeire A, Remon JP. The stability of morphine and the stability of concentrated morphine solutions in glass, polypropylene syringes and PVC containers. Int J Pharm 1997 ; 146: 213-223.
1228	Journal	Allen LV, Stiles ML. Compatibility of various admixtures at Y-injection sites of intravenous administration sets. Part2. Am J Hosp Pharm 1981 ; 38: 380-381.
1264	Journal	Truelle-Hugon B, Tourette G, Couineaux B, Gache-Charrette C. Study of Lavoisier morphine chlorhydrate in different active perfusion systems after reconstitution in different solvents. Ann Pharm Fr 1997 ; 55: 216-223.
1506	Journal	Lopez-Cabezas C, Guerrero L, Molas G, Anglada H, Soy D. Physicochemical compatibility of high concentration drugs usually Y-site administered in intensive care units. EJHP 2015 ;22:107-112.
1508	Journal	Voirol P, Berger-Gryllaki M, Pannatier A, Eggimann P, Sadeghipour F. Visual compatibility of insulin aspart with intravenous drugs frequently used in ICU. EJHP 2015 ;22:123-124.
1513	Manufacturer	Quinupristine / dalfopristine (Synercid®) - Résumé des caractéristiques du produit Monarch Pharmaceuticals Ireland 2006
1757	Journal	Schrijvers D, Tai-Apin C, De Smet MC, Cornil P, Vermorken JB, Bruyneel P. Determination of compatibility and stability of drugs used in palliative care. J Clin Pharm Ther 1998 ; 23: 311-314.
1842	Journal	Sadjack A, Wintersteiger R. Compatibility of morphin, baclofen, floxuridine and fluorouracil in an implantable infusion pump. Arzneimittel Forschung 1995 ; 45: 93-98.
1866	Journal	Vermeire A, Remon JP. Compatibility and stability of morphine in binary admixtures with haloperidol, midazolam, dexamethasone or methylprednisolone. Int J Pharm 1998 ; 174: 157-177.
1885	Journal	Essink-Tjebbes CM, Burger DM, Beelen, Wuis EW, Heckster YA. Long-term stability of morphine and bupivacaine mixture for spinal use. Pharm World Sci 1999 ; 21: 144-146.
1966	Journal	Barcia E, Reyes R, Azuara L, Sànchez Y, Negro S. Stability and compatibility of binary mixtures of morphine hydrochloride with hyoscine-n-butyl bromide. Support Care Cancer 2005 ; 13, 4: 239-245.
1971	Journal	Azuara ML, Sanchez Y, Reyes R, Barcia E. Physical compatibility and in vivo evaluation of drug mixtures forsubcutaneous infusion to cancer patients in palliative care. Support Care Cancer 2001
2055	Journal	Negro S, Reyes R, Azuara ML, Sanchez Y, Barcia E. Morphine, haloperidol and hyoscine N-butyl bromide combined in sc infusion solutions : compatibility and stability evaluation in terminal oncology patients. Int J Pharm 2006 ; 307: 278-284.
2262	Journal	Brammer MK, Chan P, Heatherly K, Trusley C, Kupiec TC, Trissel LA, Psathas PA, Gilmor T, Schaufelberger D. Compatibility of doripenem with other drugs during simulated Y-site administratioN Am J Health-Syst Pharm 2008 ; 65: 1261-1265.
2362	Poster	Trittler R, M?ller S, Esteban M. Morphin-Haloperidol mischungen in PCA Pumpen : Kompatibel? ADKA Congress 2009 2009
2363	Poster	M?ller S, Trittler R, Schubert R, von Hornstein W.F, Strehl E. Morphin-Metamizol mischungen zur kontinuierlichen parenteralen applikation : Sind sie immer inkompatibel? ADKA Congress 2006
3169	Journal	Raffaeli W, Pari G, Visani L et al. Experimentation about precipitation of pharmacological association: morphine and ketorolac. Pain Clinic 1999 ; 11: 213-216.
3332	Manufacturer	Tigecycline (Tigacyl®) - Summary of Product characteristics Pfizer 2012
3415	Journal	d?Hayer B, Vieillard V, Astier A, Paul M Stability-Indicating HPLC Assay and Stability Study Over Two Years of Morphine Hydrochloride Diluted Solutions in Polypropylene Syringes Pharmaceut Anal Acta 2013 ; 4: 205
3470	Journal	Destro M, Ottolini L, Vicentini L, Boschetti S. Physical compatibility of binary and tertiary mixtures of morphine and methadone with other drugs for parenteral administration in palliative care. Support Care Cancer 2012 ; 20: 2501-2509.
3474	Manufacturer	Fluorouracil - Summary of Product Characteristics Accord Healthcare Limited 2009
3504	Manufacturer	Parecoxib (Dynastat®) - Summary of Product Characteristics Pfizer 2012
3572	Journal	Hecq J-D, Godet M, Gillet P, Jamart J, Galanti L. Long-term Stability of Morphine Hydrochloride in 0.9% NaCl Infusion Polyolefin Bags After Freeze-thaw Treatment and in Polypropylene Syringes at 5°C ± 3°C. Int J Pharm Compound 2014 ; 18, 1 : 78-82.
3675	Manufacturer	Thiopental sodium - Summary of Product Characteristics Archimedes Pharma UK Ltd 2015
3791	Poster	Sadou Yaye H, Burtet E, Hamel C, Aljhni R, Gard C, Tilleul P. Étude de la compatibilité physico-chimique du phloroglucinol injectable durant les mélanges au sein des tubulures en Y. Apifh Congress, Paris November 2014 2014
3934	Manufacturer	Eptifibatide (Integrilin®) - Résumé des caractéristiques du produit GlaxoSmithKline Laboratoire 2016
3976	Journal	Du Repaire T, Vigne P, Guedon A, Gauthier-Villano L, Bertault Peres P, Pourroy B. Visual compatibility of blinatumomab with selected co-administrated drugs during simulated Y-site administration. Am J Health-Syst Pharm 2017 ; 74,16 : 1217-1218
4034	Journal	Chen F-C, Fang B-X, Li P, Zheng F, Shi X-Y. Compatibility and stability of lornoxicam with morphine, tramadol or fentanyl in infusion solutions. Afr J Pharm Pharmacol 2012 ;27,6:2055-2060
4051	Journal	Robert J, Sorrieul J, Kieffer H, Folliard C, Gibory V, Dupoiron D, Devys C. Stability study of morphine and baclofen solution in polypropylene syringes. Pharmaceutical Technology in Hospital Pharmacy 2017 ;2,4:173-180
4332	Poster	Compatibilité de Glycophos® avec d’autres médicaments administrés en perfusion aux soins intensifs (SI) Compatibilité de Glycophos® avec d’autres médicaments administrés en perfusion aux soins intensifs (SI). JFSPH 2019 2019
4404	Poster	Müller U, Haller F, Wiedemeier P, Steuer C. Compatibility studies of seven commonly used drugs for parenteral administration in palliative care. JFSPH 2019 2019
4538	Journal	Campbell A, Petrovski M, Senarathna G, Mukadam ,Strunk T, Batty K. Compatibility of pentoxifylline and parenteral medications. Archives of Disease in Childhood 2020 ; 105: 395-397.
4543	Journal	Senarathna G, Strunk T, Petrovski M, Batty K. Physical compatibility of pentoxifylline and intravenous medications. Archives of Disease in Childhood 2018 ;104:292–295.
4545	Journal	Kondo M, Nagano M, Yoshida M, Yoshida N, Tagui N, Yoshida M, Sugaya K, Takase H. Physical compatibility of nafamostat with analgesics, sedatives, and muscle relaxants for coronavirus disease treatment. Journal of Nippon Medical school 2021
4643	Journal	Catry E, Colsoul M-L, Closset M, Nyssen C, Hubert J, Soumoy L, Bihin B, Jamart J, Hecq J-D, Galanti L. Evaluation of 30-day stability of morphine hydrochloride and clonidine at high and low concentrations in polypropylene syringes. EJHP 2021
4651	Journal	De Basagoiti A, Katsumiti A, Abascal S, Bustinza A, López-Giménez L.R, Pascual P, De Miguel M, Campino A. Physical compatibility of alprostadil with selected drugs commonly used in the neonatal intensive care units. Eur J Pedia 2021 ;180,1169–1176.
4664	Journal	Harder M, Fiegl-Lechner A, Oberacher H, Horvath U.E.I, Schlager A, Jeske M, Kerndler S, Schüllner F, Bonn G.F, Rainer M. Stability evaluation of morphine, hydromorphone, metamizole and esketamine containing analgesic mixtures applied for patient-controlled analgesia in hospice and palliative care. Biomed Chromatogr 2022 ;e5340.
4667	Journal	Ping L, juan H, Li R-L, Feng Z-Y, Zhou X-J, Liu M-F, Jing B, Jian L. Stability of Hydromorphone Hydrochloride and Morphine under Different Clinical Infusion Conditions. Int J Pharm Pharm Sci 2019 ;81(6):1140-114
4768	Journal	Kondo M, Genpei M, Watanabe K, Yoshida M, Tagui N, Fukao S, Sugaya K, Takase H. Y-site injection physical compatibility of remdesivr with select intravenous drugs used in palliative care and for treating coronavirus disease 2019. Journal of Nippon Medical school 2023