Last update :
07/07/2025
References   References 4929  
Type : Journal
Web link : https://ijpc.com/Abstracts/Abstract.cfm?ABS=5452

Research teams : Mont Godinne - Drug Stability Research Group (DSRG) - CHU UCL NAMUR, site de Godinne
Authors : Nobels A, Closset M, Bihin B, Jamart J, Soumoy L, Lombet L, Hecq JD, Galanti L, Colsoul ML, Catry E.
Title : Long-term Physicochemical Stability of a Pharmaceutical Preparation of Morphine Hydrochloride and Droperidol in Polypropylene Syringes.
Reference : Int J Pharm Compound ;29,2:141-149 2025

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionDroperidol Neuroleptic
injectionMorphine hydrochloride Analgesic
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 21-25°C Protect from light
injection Droperidol 0,083 mg/ml
injection Morphine hydrochloride 2 mg/ml
50 Day

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