Last update :
19/11/2024
Sympathomimetic   Phenylephrine hydrochloride  
injection
Eye-drops
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Biorphen
Fedalefrina Argentina
Fencel India
Fenilefrina Argentina, Spain
Fenylefrin Iceland
Frenin India
Neo - Synephrine Canada
Neosynephrine France
Phenylephrin Germany, Switzerland
Phenylephrine Canada, Great Britain, Iran
Compatibility   injection   Compatibility : Phenylephrine hydrochloride              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Immediate turbidity Incompatible
injection Phenylephrine hydrochloride 0,04 mg/ml
Normosol® 4655
Compatible
injection Phenylephrine hydrochloride 0.04 mg/ml
injection Amiodarone hydrochloride 4 mg/ml
NaCl 0,9% or Glucose 5% 1036
Unspecified incompatibility Incompatible
injection Phenylephrine hydrochloride
injection Amoxicillin sodium / clavulanic acid
3545
Compatible
injection Phenylephrine hydrochloride 0,01 mg/ml
injection Amoxicillin sodium / clavulanic acid 100/10 mg/ml
3824
Compatible
injection Phenylephrine hydrochloride
injection Angiotensin II
Sodium chloride 0,9% 4818
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Anidulafungin 0.5 mg/ml
Glucose 5% 1982
Compatible
injection Phenylephrine hydrochloride 10 mg/ml
injection Argatroban 1 mg/ml
Sodium chloride 0,9% 1964
Compatible
injection Phenylephrine hydrochloride 10 mg/ml
injection Bivalirudin 5 mg/ml
NaCl 0,9% or Glucose 5% 1944
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Bivalirudin 5 mg/ml
Glucose 5% 1713
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Caspofungin acetate 0,7 mg/ml
Sodium chloride 0,9% 2247
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Cefiderocol sulfate tosylate 20 mg/mL
Sodium chloride 0,9% 4528
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Ceftolozane / tazobactam 10/5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Cisatracurium besylate 0.1 >> 5 mg/ml
Glucose 5% 299
Compatible
injection Phenylephrine hydrochloride 0.04 mg/ml
injection Dobutamine hydrochloride 2 mg/ml
Glucose 5% 1041
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Doripenem 5 mg/ml
NaCl 0,9% or Glucose 5% 2262
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Eravacycline 0,6 mg/ml
Sodium chloride 0,9% 4434
Compatible
injection Phenylephrine hydrochloride 10 mg/ml
injection Etomidate 2 mg/ml
None 319
Compatible
injection Phenylephrine hydrochloride 0.02 mg/ml
injection Famotidine 0.2 mg/ml
Glucose 5% 398
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Fenoldopam mesylate 80 µg/ml
Sodium chloride 0,9% 1803
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Fosfomycin 30 mg/ml
NaCl 0,9% or Glucose 5% 4055
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Furosemide 10 mg/ml
None 3210
Immediate precipitation Incompatible
injection Phenylephrine hydrochloride 0.64 mg/ml
injection Furosemide 4 mg/ml
NaCl 0,9% or Glucose 5% 2116
Compatible
injection Phenylephrine hydrochloride 0.02 mg/ml
injection Haloperidol lactate 0.5 & 5 mg/ml
Glucose 5% 403
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Hetastarch 60 mg/ml
specific solvent 1721
Compatible
injection Phenylephrine hydrochloride 0,2 mg/ml
injection Imipenem-Cilastatin / Relebactam 5 mg/ml
NaCl 0,9% or Glucose 5% 4433
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Isavuconazonium sulfate 1.5 mg/ml
NaCl 0,9% or Glucose 5% 3829
Precipitation after 4 hours Incompatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Compatible
injection Phenylephrine hydrochloride 2.5 mg/ml
injection Lidocaine hydrochloride 20 mg/ml
None 1331
Unspecified incompatibility Incompatible
injection Phenylephrine hydrochloride
NaHCO3 3620
Unspecified incompatibility Incompatible
injection Phenylephrine hydrochloride
injection Iron (polymaltose)
3620
Compatible
injection Phenylephrine hydrochloride 10 mg/ml
injection Levofloxacine 5 mg/ml
Glucose 5% 1072
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Micafungin 1.5 mg/ml
Sodium chloride 0,9% 2108
Compatible
injection Phenylephrine hydrochloride 0.2 mg/ml
injection Oritavancin 0.8 >>2 mg/ml
Glucose 5% 3152
Compatible
injection Phenylephrine hydrochloride 10 mg/ml
injection Paracetamol 10 mg/ml
4742
Unspecified incompatibility Incompatible
injection Phenylephrine hydrochloride
injection Phenytoin sodium
3620
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Plazomicin sulfate 24 mg/ml
Sodium chloride 0,9% 4145
Compatible
injection Phenylephrine hydrochloride 0.1 mg/ml
injection Propofol 10 mg/ml
None 300
Compatible
injection Phenylephrine hydrochloride 10 mg/ml
injection Propofol 2 mg/ml
None 319
Instability of the emulsion after 6 hours Incompatible
injection Phenylephrine hydrochloride 0.1 mg/ml
injection Propofol
660
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Remifentanil hydrochloride 25 & 250 µg/ml
Sodium chloride 0,9% 59
Unspecified incompatibility Incompatible
injection Phenylephrine hydrochloride
injection Sodium bicarbonate
3620
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Sulbactam/durlobactam 15/15 mg/ml
Sodium chloride 0,9% 4801
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Tedizolid phosphate 0.8 mg/ml
Sodium chloride 0,9% 3827
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Telavancin hydrochloride 7.5 mg/ml
Ringer’s lactate solution 3254
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Telavancin hydrochloride 7.5 mg/ml
NaCl 0,9% or Glucose 5% 3254
Immediate precipitation Incompatible
injection Phenylephrine hydrochloride 10 mg/ml
injection Thiopental sodium 25 mg/ml
Water for Injection 319
Compatible
injection Phenylephrine hydrochloride 0.04 mg/ml
injection Vasopressin 2 & 4 UI/ml
Sodium chloride 0,9% 1801
Compatible
injection Phenylephrine hydrochloride 1 mg/ml
injection Zidovudine 4 mg/ml
Glucose 5% 337

  Mentions Légales