Last update :
General anesthetic   Thiopental sodium  
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Anapental Egypt
Anental Colombia, Venezuela
Epental Saudi Arabia
Exipental Iran
Farmotal Italy
Gabapentax Colombia
Hipnopento Argentina
Nesdonal Netherlands
Pantul Ecuador, Peru
Pensodital Mexico
Pental Turkey
Pentarim Mexico
Pentax Venezuela
Pentocur Iceland, Norway
Pentotex Malaysia
Pentothal Australia, Belgium, Canada, Denmark, Finland, Greece, Italy, Luxembourg, Mexico, Sweden, Switzerland
Sodipental Colombia, Mexico
Thiojex Chile
Thiomek Peru
Thiopental Austria, Egypt, France, Germany, Great Britain, Greece, Hungary, Iran, Ireland, Malaysia, Morocco, Poland, Romania, Saudi Arabia, Tunisia
Thiopentax Ecuador, Venezuela
Tiobarbital Colombia, Spain
Trapanal Germany
Zedisol Mexico
References   Injection   References : Thiopental sodium  
Type Publication
59 Journal Trissel LA, Gilbert DL, Martinez JF, Kim MC.
Compatibility of remifentanil hydrochloride with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 2192-2196.
125 Journal Chernin EL, Stewart JT, Smiler B.
Stability of thiopental sodium and propofol in polypropylene syringes at 23 and 4°C.
Am J Health-Syst Pharm 1996 ; 53: 1576-1579.
126 Journal Prankerd RJ, Jones RD.
Physicochemical compatibility of propofol with thiopental sodium.
Am J Health-Syst Pharm 1996 ; 53: 2606-2610.
299 Journal Trissel LA, Martinez JF, Gilbert DL.
Compatibility of cisatracurium besylate with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 1735-1741.
314 Journal Chiu MF, Schwartz ML.
Visual compatibility of injectable drugs used in the intensive care unit.
Am J Health-Syst Pharm 1997 ; 54: 64-65.
319 Journal Hadzija BW, Lubarsky DA.
Compatibility of etomidate, thiopental sodium, and propofol injections with drugs commonly administered during induction of anesthesia.
Am J Health-Syst Pharm 1995 ; 52: 997-999.
350 Journal Martens HJ, De Goede PN, Van Loenen AC.
Sorption of various drugs in polyvinyl chloride, glass, and polyethylene-lined infusion containers.
Am J Hosp Pharm 1990 ; 47: 369-373.
527 Journal Das Gupta V, Neal Gardner S, Jolowsky CM, Newcomer DR, Stewart KR.
Chemical stability of thiopental sodium injection in disposable plastic syringes.
J Clin Pharm Ther 1987 ; 12: 339-342.
642 Journal Baumgartner TG, Knudsen AK, Dunn AJ, Kilroy RA.
Norepinephrine stability in saline solutions.
Hosp Pharm 1988 ; 23: 44,49, 59.
755 Manufacturer Pancuronium (Pavulon®) - Résumé des caractéristiques du produit
MSD France 2016
871 Journal Haws JL, Herman N, Clark Y, Bjoraker R, Jones D.
The chemical stability and sterility of sodium thiopental after preparation.
Anesth Analg 1998 ; 86: 208-213.
919 Journal Lazar ER, Jolly DT, Tam YK, Hrazdil J, Tawfik SR, Clanachan AS.
Propofol and thiopental in a 1:1 volume mixture is chemically stable.
Anesth Analg 1998 ; 86: 422-426.
1173 Journal Kowaluk EA, Roberts MS, Blackburn HD, Polack AE.
Interactions between drugs and polyvinyl chloride infusion bags.
Am J Hosp Pharm 1981 ; 38: 1308-1314.
1713 Journal Trissel LA, Saenz CA.
Compatibility screening of bivalirudin during simulated Y-site administration with other drugs.
Int J Pharm Compound 2002 ; 6: 311-315.
1721 Journal Trissel LA, Williams KY, Baker MB.
Compatibility screening of Hextend during simulated Y-site administration with other drugs.
Int J Pharm Compound 2001 ; 5: 69-72.
1803 Journal Trissel, LA, Saenz CA, Ogundele OB, Ingram D, Baker MB.
Compatibility of fenoldopam mesylate with other drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2003 ; 60: 80-85.
2073 Journal Taniguchi T, Yamamoto K, Kobayashi T.
Precipitate formed by thiopentone and vecuronium causes pulmonary embolism.
Can J Anesth 1998 ; 45: 347-351.
2079 Journal Morton WD, Lerman J.
The effect of pancuronium on the solubility of aqueous thiopentone.
Can J Anesth 1987 ; 34: 87-89.
2090 Journal Pere H, Chasse V, Forest JM, Hildgen P.
Compatibility of injectable pantoprazole in Y-site administration.
Pharmactuel 2004 ; 37: 193-196.
2105 Journal Valverde molina F, Hernandez Hernandez G, Munoz Castillo M, Novales Duran J, Gallego Fernandez C.
Estabilidad de una mezcla de etomidato y pentotal para administracion intravenosa en bolo.
Farm Hosp 1999 ; 23: 357-360.
2146 Journal Trissel LA, Xu QA, Baker M.
Drug compatibility with new polyolefin infusion solution containers.
Am J Health-Syst Pharm 2006 ; 63: 2379-2382.
2231 Journal de Jongh R, Hens R, Basma V, mouton JW, Tulkens PM, Carryn S.
Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection.
J Antimicrob Chemother 2008 ; 61, 2: 382-388.
3134 Journal Perez Jua En, Maqueda Palau M, Arévalo Rubert Mt, Ribas Nicolau B, Amoros Cerdà SM.
Compatibilidad visual y física de la furosemida en mezclas intravenosas para perfusión continua.
Enferm Intensiva 2010 ; 21: 96-103.
3212 Journal Ribas Nicolau, B.; P?rez Juan, E.; Amor?s Cerd?, S.M.; Ar?valo Rubert, M.J.; Maqueda Palau, M.
Compatibilidad física del bicarbonato sódico con fármacos de uso frecuente en la unidad de cuidados intensivos.
Enferm Intensiva 2011 ;22:78-82.
3372 Journal Hanci V, Ali Kiraz H, Ömür D, Ekin S, Uyan B, Yurtlu B.S.
Precipitation in Gallipoli: Sugammadex / Amiodarone & Sugammadex / Dobutamine & Sugammadex / Protamine.
Rev Bras Anestesiol 2013 ; 63, 1: 163-166.
3373 Journal Khan S, Stannard N, Greijn J.
Precipitation of thiopental with muscle relaxants: a potential hazard.
J R Soc Med Sh Rep 2011 ; 2: 58.
3377 Journal Huddy NC, Durcan JJ.
Precipitation betwen meptazinol and thiopentone.
Anaesthesia 1983 ; 38: 601-602.
3408 Journal Tollec S, Touzin K, Pelletier E, Forest J.M.
Evaluation visuelle de la compatibilité physique de la naloxone avec d’autres médicaments intraveineux usuels.
Pharmactuel 2013 ; 46, 1 : 16-21.
3464 Journal Monica Maqueda-Palau, Eva Pérez-Juan, Maria Josep Arévalo-Rubert, Sylvia Monica Amoros-Cerda, Bàrbara Ribas-Nicolau.
Compatibilidad física de la amiodarona en perfusión continua
Enferm Clin 2011 21:25-29.
3466 Journal B. Ribas Nicolau, E. P?rez Juan, S.M. Amor?s Cerd?, M.J. Ar?valo Rubert, M. Maqueda Palau.
Compatibilidad física del bicarbonato sódico con fármacos de uso frecuente en la unidad de cuidados intensivos
Enferm Intensiva 2011 ;22:78-82.
3501 Manufacturer Ketamine hydrochloride (Ketalar®) - Summary of Product Characteristics
Pfizer 2011
3503 Manufacturer Fentanyl - Summary of product Characteristics
Hameln Pharmaceuticals 2012
3525 Manufacturer Pethidine hydrochloride - Summary of product Characteristics
AMCO Amdipharm Mercury 2012
3526 Manufacturer Clindamycin (Dalacin®) - Summary of Product Characteristics
Pharmacia 2010
3531 Manufacturer Morphine sulphate 10 mg/mL injection BP – Summary of Product Characteristics
Wockhardt 2014
3549 Manufacturer Amikacine B Braun - Résumé des caractéristiques du produit.
B Braun 2012
3564 Manufacturer Rocuronium B Braun - Résumé des caractéristiques du produit.
B Braun 2012
3599 Manufacturer Glycopyrrolate Injection U.S.P. - Summary of Product Characteristics
Amco Amdipharm Mercry 2013
3600 Manufacturer Hydroxyzine (Atarax®) - Résumé des caractéristiques du produit
UCB Pharma SA 2009
3601 Manufacturer Cisatracurium Actavis - Résumé des Caractéristiques du Produit
Actavis 2012
3607 Manufacturer Esmolol hydrochloride for injection - Summary of Product Characteristics
AOP Orphan Pharmaceuticals AG 2013
3612 Manufacturer Doxapram (Dopram) - Summary of Product Characteristics
Amdipharm Mercury Company 2012
3614 Manufacturer Nicardipine Injection - Summary of Product Characteristics
American Regent Inc 2013
3629 Manufacturer Atracurium (Atracurium solution for injection/infusion®) - Summary of Product Characteristics
Actavis UK 2014
3630 Manufacturer Vecuronium (Norcuron®) - Summary of Product Characteristics
Merck Sharp Dohme 2012
3631 Manufacturer Suxamethonium (Suxamethonium Aguettant®) - Résumé des caractéristiques du produit
Aguettant 2016
3674 Manufacturer Erythromycin lactobionate - Summary of Product Characteristics
PanPharma 2016
3675 Manufacturer Thiopental sodium - Summary of Product Characteristics
Archimedes Pharma UK Ltd 2015
3676 Manufacturer Atracurium bésilate (Atracurium Hospira®) - Résumé des caractéristiques du produit
Hospira 2014
3767 Journal Legris M.E, Lavoie A, Forrest J.M, Hildgen P.
Compatibilité par évaluation visuelle du thiopental injectable lors de son administration en Y avec des médicaments usuels.
Pharmactuel 2014 ; 47, 3 : 167-172.
3823 Journal Juan E.P, Palau M.M, Cerd? S.A, Rubert M.A, Nicolau B.R.
Compatibilité physique de médicaments administrés dans l’unité de soins intensifs
Pharmactuel 2015 ; 48, 3 : 146-152.
3932 Manufacturer Hydroxocobalamine (Cyanokit®) - Résumé des caractéristiques du produit
Serb Laboratoire 2015
3941 Manufacturer Nicardipine - Summary of Product Characteristics
Concordia International 2017
4009 Manufacturer
Droperidol - Résumé des Caractéristiques du Produit
Panpharma 2017
4428 Journal Rashed S.M, Sweatman T.W, Thoma L, Hovinga C.A, Phelps S.J.
Chemical Compatibility of Depacon® with Medications Frequently Administered by Intravenous Y-Site Delivery in Patients with Epilepsy or Head Trauma.
J Pediatr Pharmacol Ther 2004 ; 9, 2: 126-132.
4700 Manufacturer Esketamine 25 mg/mL solution for injection/infusion. - Summary of Product Characteristics
AS Kalceks 2022

  Mentions Légales