Last update :
19/11/2024
Neuroleptic   Haloperidol lactate  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Aloperidin Greece
Aloperidolo Italy
Haldol Australia, Austria, Belgium, Chile, Denmark, Ecuador, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Japan, Luxembourg, Malaysia, Mexico, Morocco, Norway, Poland, Sweden, Switzerland, Tunisia, Venezuela
Halodic Iran
Halonace Egypt
Haloperidol Colombia, Ecuador, Egypt, Great Britain, Hungary, Iran, Peru, Portugal
Halopidol Argentina, Colombia
Haloprol Egypt
Manace Malaysia
Norodol Turkey
Serenace Australia, Great Britain, Ireland, New Zealand
Serenase Italy
Serenelfi Portugal
Sylador Saudi Arabia
References   injection   References : Haloperidol lactate  
Type Publication
3 Journal Trissel LA, Martinez JF.
Compatibility of amifostine with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1995 ; 52: 2208-2212.
59 Journal Trissel LA, Gilbert DL, Martinez JF, Kim MC.
Compatibility of remifentanil hydrochloride with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 2192-2196.
73 Journal Lor E, Takagi J.
Visual compatibility of foscarnet with other injectable drugs.
Am J Hosp Pharm 1990 ; 47: 157-159.
81 Journal Trissel LA, Martinez JF.
Compatibility of piperacillin sodium plus tazobactam with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1994 ; 51: 672-678.
84 Journal Trissel LA, Martinez JF.
Visual, turbidimetric, and particle-content assessment of compatibility of vinorelbine tartrate with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1994 ; 51: 495-499.
85 Journal Trissel LA, Bready BB.
Turbidimetric assessment of the compatibility of taxol with selected other drugs during simulated Y-site injection.
Am J Hosp Pharm 1992 ; 49: 1716-1719.
91 Journal Lober CA, Dollard PA.
Visual compatibility of gallium nitrate with selected drugs during Y-site injection.
Am J Hosp Pharm 1993 ; 50: 1208-1210.
93 Journal Hutchings SR, Rusho WJ, Tyler LS.
Compatibility of cefmetazole sodium with commonly used drugs during Y-site delivery.
Am J Health-Syst Pharm 1996 ; 53: 2185-2188.
99 Journal Trissel LA, Martinez JF.
Compatibility of aztreonam with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1995 ; 52: 1086-1090.
169 Journal Trissel LA, Martinez JF.
Physical compatibility of melphalan with selected drugs during simulated Y-site administration.
Am J Hosp Pharm 1993 ; 50: 2359-2363.
182 Journal Trissel LA, Gilbert DL, Martinez JF.
Compatibility of granisetron hydrochloride with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 56-60.
186 Journal Swart EL, Mooren RAG, Van Loenen AC.
Compatibility of midazolam hydrochloride and lorazepam with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1995 ; 52: 2020-2022.
188 Journal Gibler B, Kim MS, Raleigh F.
Visual compatibility of neuroleptics with anticholinergics or antihistamines in polyethylene syringes.
Am J Hosp Pharm 1994 ; 51: 2709-2710.
215 Journal Keyi X, Gagnon N, Bisson C, Desmarais M, LeBel M.
Stability of famotidine in polyvinyl chloride minibags and polypropylene syringes and compatibility of famotidine with selected drugs.
Ann Pharmacotherapy 1993 ; 27: 422-426.
216 Journal Huang E, Anderson RP.
Compatibility of hydromorphone hydrochloride with haloperidol lactate and ketorolac tromethamine.
Am J Hosp Pharm 1994 ; 51: 2963.
228 Journal Mendenhall A, Hoyt DB.
Incompatibility of ketorolac tromethamine with haloperidol lactate and triethylperazine maleate.
Am J Hosp Pharm 1994 ; 51: 2964.
229 Journal Jackson CW, Cunningham K.
Compatibility of haloperidol lactate with benztropine mesylate.
Am J Hosp Pharm 1994 ; 51: 2962-2963.
230 Journal Fraser GL, Riker RR.
Visual compatibility of haloperidol lactate with injectable solutions.
Am J Hosp Pharm 1994 ; 51: 905-906.
244 Journal Trissel LA, Martinez JF.
Compatibility of filgrastim with selected drugs during simulated Y-site administration.
Am J Hosp Pharm 1994 ; 51: 1907-1913.
249 Journal Trissel LA, Martinez JF.
Compatibility of thiotepa (lyophilized) with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1996 ; 53: 1041-1045.
251 Journal Trissel LA, Gilbert DL, Martinez JF.
Compatibility of doxorubicin hydrochloride liposome injection with selected other drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 2708-2713.
253 Journal Trissel LA, Chandler SW, Folstad JT.
Visual compatibility of amsacrine with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1990 ; 47: 2525-2528.
299 Journal Trissel LA, Martinez JF, Gilbert DL.
Compatibility of cisatracurium besylate with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 1735-1741.
300 Journal Trissel LA, Gilbert DL, Martinez JF.
Compatibility of propofol injectable emulsion with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 1287-1292.
301 Journal Trissel LA, Gilbert DL, Martinez JF, Baker MB, Walter WV, Mirtallo JM.
Compatibility of parenteral nutrient solutions with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 1295-1300.
307 Journal Trissel LA, Martinez JF.
Compatibility of allopurinol sodium with selected drugs during simulated Y-site administration.
Am J Hosp Pharm 1994 ; 51: 1792-1799.
334 Journal Trissel LA, Tramonte SM, Grilley BJ.
Visual compatibility of ondansetron hydrochloride with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1991 ; 48: 988-992.
335 Journal Trissel LA, Bready BB, Kwan JW, Santiago NM.
Visual compatibility of sargramostim with selected antineoplasic agents, anti-infectives, or other drugs during simulated Y-site injection.
Am J Hosp Pharm 1992 ; 49: 402-406.
403 Journal Outman WR, Monolakis J.
Visual compatibility of haloperidol lactate with 0.9% sodium chloride injection or injectable critical-care drugs during simulated Y-site injection.
Am J Hosp Pharm 1991 ; 48: 1539-1541.
479 Journal Min DI, Brown T, HWang GC.
Visual compatibility of tacrolimus with commonly used drugs during simulated Y-site injection.
Am J Hosp Pharm 1992 ; 49: 2964-2966.
492 Journal Trissel LA, Parks NPT, Santiago NM.
Visual compatibility of fludarabine phosphate with antineoplastic drugs, anti-infectives, and other selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1991 ; 48: 2186-2189.
496 Journal Lor E, Sheybani T, Takagi J.
Visual compatibility of fluconazole with commonly used injectable drugs during simulated Y-site administration.
Am J Hosp Pharm 1991 ; 48: 744-746.
605 Journal Das Gupta V, Stewart KR.
Stability of haloperidol in 5% dextrose injection.
Am J Hosp Pharm 1982 ; 39: 292-294.
617 Journal Solomon DA, Nasinnyk KK.
Compatibility of haloperidol lactate and heparin sodium.
Am J Hosp Pharm 1982 ; 39: 843-844.
779 Journal Collins AJ, Abethell JA, Holmes SG, Rain R.
Stability of diamorphine hydrochloride with haloperidol in prefilled syringes for continuous subcutaneous administration.
J Pharm Pharmacol 1986 ; 38: 51P.
905 Journal Trissel LA, Martinez JF.
Screening teniposide for Y-site physical incompatibilities.
Hosp Pharm 1994 ; 29: 1010-1017.
921 Journal Trissel LA, Gilbert DL, Martinez JF.
Incompatibility and compatibility of amphotericin B cholesteryl sulfate complex with selected other drugs during simulated Y-site administration.
Hosp Pharm 1998 ; 33: 284-292.
939 Journal Gilbar PJ, Groves CF.
Visual compatibility of total parenteral nutrition solution (Synthamin 17 Premix*) with selected drugs during simulated Y-site injection.
Aust J Hosp Pharm 1994 ; 24: 167-170.
982 Journal Ukhun IA.
Compatibility of haloperidol and diphenhydramine in a hypodermic syringes.
Ann Pharmacotherapy 1995 ; 29: 1168.
985 Journal Raleigh FR, Gibler BS.
Haloperidol and diphenhydramine compatibility.
Ann Pharmacotherapy 1996 ; 30: 549.
1230 Journal Regnard C, Pashley S, Westrope F.
Anti-emetic / diamorphine mixture compatibility in infusion pumps.
Br J Pharm Pract 1986 ; 8: 218-220.
1410 Journal Trissel LA, Martinez JF, Simmons M.
Compatibility of etoposide phosphate with selected drugs during simulated Y-site injection.
J Am Pharm Assoc 1999 ; 39: 141-145.
1415 Journal Trissel L.A, Gilbert D.L, Martinez J.F, Baker M.B, Walter W.V, Mirtallo J.M.
Compatibility of medications with 3-in-1 parenteral nutrition admixtures.
JPEN 1999 ; 23: 67-74.
1423 Journal Trissel LA, Martinez JF, Gilbert DL.
Compatibility of gemcitabine hyrochloride with 107 selected drugs during simulated Y-site injection.
J Am Pharm Assoc 1999 ; 39: 514-518.
1492 Journal LeBelle MJ, Savard C, Gagnon A.
Compatibility of morphine and midazolam or haloperidol in parenteral admixtures.
Can J Hosp Pharm 1995 ; 48: 155-160.
1496 Journal Trissel LA, Martinez JF, Gilbert DL.
Screening cladribine for Y-site physical compatibility with selected drugs.
Hosp Pharm 1996 ; 31: 1425-1428.
1513 Manufacturer Quinupristine / dalfopristine (Synercid®) - Résumé des caractéristiques du produit
Monarch Pharmaceuticals Ireland 2006
1625 Journal Trissel LA, Saenz C, Williams YW, Ingram D.
Incompatibilities of lansoprazole injection with other drugs during simulated Y-site coadministration.
Int J Pharm Compound 2001 ; 5: 314-321.
1643 Journal Raleigh F, Gibler B.
Haldol-benztropine incompatibility.
Hosp Pharm 1994 ; 29: 76.
1662 Journal Trissel LA, Saenz CA, Ingram DS, Ogundele AB.
Compatibility screening of oxaliplatin during simulated Y-site administration with other drugs.
J Oncol Pharm Practice 2002 ; 8: 33-37.
1712 Journal Trissel LA, Saenz CA.
Compatibility screening of Precedex during simulated Y-site administration with other drugs.
Int J Pharm Compound 2002 ; 6: 230-233.
1713 Journal Trissel LA, Saenz CA.
Compatibility screening of bivalirudin during simulated Y-site administration with other drugs.
Int J Pharm Compound 2002 ; 6: 311-315.
1721 Journal Trissel LA, Williams KY, Baker MB.
Compatibility screening of Hextend during simulated Y-site administration with other drugs.
Int J Pharm Compound 2001 ; 5: 69-72.
1724 Journal Elbe D, Condé C.
Visual compatibility of various injectable neuroleptic agents with benztropine and lorazepam in polypropylene syringes.
Can J Hosp Pharm 2001 ; 54: 102-105.
1754 Journal Trissel LA, Gilbert DL, Wolkin AC.
Compatibility of docetaxel with selected drugs during simulated Y-site administration.
Int J Pharm Compound 1999 ; 3: 241-244.
1757 Journal Schrijvers D, Tai-Apin C, De Smet MC, Cornil P, Vermorken JB, Bruyneel P.
Determination of compatibility and stability of drugs used in palliative care.
J Clin Pharm Ther 1998 ; 23: 311-314.
1803 Journal Trissel, LA, Saenz CA, Ogundele OB, Ingram D, Baker MB.
Compatibility of fenoldopam mesylate with other drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2003 ; 60: 80-85.
1866 Journal Vermeire A, Remon JP.
Compatibility and stability of morphine in binary admixtures with haloperidol, midazolam, dexamethasone or methylprednisolone.
Int J Pharm 1998 ; 174: 157-177.
1886 Journal Allwood MC.
The stability of diamorphine alone and in combinaison with antiemetics in plastic syringes.
Palliative Med 1991 ; 5: 330-333.
1925 Journal Trissel LA , Williams KY, Gilbert DL.
Compatibility screening of linezolid injection during simulated Y-site administration with other drugs and infusion solutions.
J Am Pharm Assoc 2000 ; 40: 515-519.
1953 Journal Trissel LA, Saenz CA, Ogundele AB, Ingram DS.
Physical compatibility of pemetrexed disodium with other drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2004 ; 61: 2289-2293.
1970 Journal Barcia E, Reyes R, Azuara M.L, S?nchez Y, Negro S.
Compatibility of haloperidol and hyoscine-N-butyl bromide in mixtures for subcutaneous infusion to cancer patients in palliative care.
Support Care Cancer 2003 ; 11, 2: 107-113.
1971 Journal Azuara ML, Sanchez Y, Reyes R, Barcia E.
Physical compatibility and in vivo evaluation of drug mixtures forsubcutaneous infusion to cancer patients in palliative care.
Support Care Cancer 2001
1974 Journal Chandler SW, Trissel LA, Weinstein SM
Combined administration of opoids with selected drugs to manage pain and other cancer symptoms initial safety screening for compatibility.
J Pain Symptom Manage 1996 ; 12, 3: 168-171.
2024 Journal Negro S, Martin A, Azuara ML, Sanchez Y, Barcia E.
Stability of tramadol and haloperidol for continuous infusion at home.
J Pain Symptom Manage 2005 ; 30: 192-199.
2055 Journal Negro S, Reyes R, Azuara ML, Sanchez Y, Barcia E.
Morphine, haloperidol and hyoscine N-butyl bromide combined in sc infusion solutions : compatibility and stability evaluation in terminal oncology patients.
Int J Pharm 2006 ; 307: 278-284.
2113 Journal Jäppinen A, Kokki H, Naaranlahti TJ, Rasi AS.
Stability of buprenorphine, haloperidol and glycopyrrolate mixture in a 0.9% sodium chloride solution.
Pharm World Sci 1999 ; 21, 6: 272-274.
2125 Journal Gardiner PR.
Compatibility of an injectable oxycodone formulation with typical diluents, syringes, tubings, infusion bags and drugs for potential co-administration.
Hospital Pharmacist 2003 ; 10: 354-361.
2166 Journal Nassr S, Dubuc MC, Lavoie P, Brazier JL.
HPLC-DAD methods for studying the stability of solutions containing hydromorphone, ketorolac, haloperidol, midazolam, famotidine, metoclopramide, dimenhydrinate and scopolamine.
J Liquid Chrom Rel Technol 2003 ; 26, 17: 2909-2929.
2269 Journal Chan P, Bishop A, Kupiec TC, Trissel LA, Gole D, Jimidar IM, Vermeersch H.
Compatibility of ceftobiprole medocaril with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2008 ; 65, 16: 1545-1551.
2362 Poster Trittler R, M?ller S, Esteban M.
Morphin-Haloperidol mischungen in PCA Pumpen : Kompatibel?
ADKA Congress 2009 2009
2900 Journal Hines S, Pleasance S.
Compatibility of an injectable high strength oxycodone formulation with typical diluents, syringes, tubings,infusion bags and drugs for potential co-administration.
EJHP 2009 ; 15, 5: 32-38.
3132 Journal Negro S, Martin A, Azuara L, Sanchez Y, Barcia E.
Compatibility and stability of ternary admixtures of tramadol, haloperidol, and hyoscine.
J Palliat Med 2010 ; 13, 3: 273-277.
3134 Journal Perez Jua En, Maqueda Palau M, Arévalo Rubert Mt, Ribas Nicolau B, Amoros Cerdà SM.
Compatibilidad visual y física de la furosemida en mezclas intravenosas para perfusión continua.
Enferm Intensiva 2010 ; 21: 96-103.
3152 Journal Kumar A, Mann HJ.
Visual compatibility of oritavancin diphosphate with selected coadministered drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2010 ; 67: 1640-1644.
3212 Journal Ribas Nicolau, B.; P?rez Juan, E.; Amor?s Cerd?, S.M.; Ar?valo Rubert, M.J.; Maqueda Palau, M.
Compatibilidad física del bicarbonato sódico con fármacos de uso frecuente en la unidad de cuidados intensivos.
Enferm Intensiva 2011 ;22:78-82.
3249 Journal Singh BM, Dedhiya MG, Dinunzio J, Chan P, Kupiec TC, Trissel LA, Laudano JB.
Compatibility of ceftaroline fosamil for injection with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2011 ; 68: 2163-2169.
3297 Journal Salmeron-Garcia A, Lopez-Lopez E, Roma E, Cabeza J, Navas N, Capitan-Vallvey L.F.
Development of an LC–DAD Method for Analysis of Dexketoprofen, Tramadol, and Haloperidol. Study of the Stability of Mixtures Used for Patient-Controlled Analgesia.
Chromatographia 2008 ; 68, 9-10: 767-772.
3332 Manufacturer Tigecycline (Tigacyl®) - Summary of Product characteristics
Pfizer 2012
3463 Journal Eva Perez Juan, Maria Jos? Arévalo Rubert , Silvia Monica Amoros Cerda , Palau M.M, Nicolau B.R.
Fármacos en perfusión continua en la unidad de cuidados intensivos: estudio de compatibilidad.
Nursing 2011 ; 29 :62-6
3464 Journal Monica Maqueda-Palau, Eva Pérez-Juan, Maria Josep Arévalo-Rubert, Sylvia Monica Amoros-Cerda, Bàrbara Ribas-Nicolau.
Compatibilidad física de la amiodarona en perfusión continua
Enferm Clin 2011 21:25-29.
3465 Journal E. P?rez Juan, M. Maqueda Palau, M. Ar?valo Rubert, B. Ribas Nicolau, S.M. Amor?s Cerd?.
Compatibilidad visual y física de la furosemida en mezclas intravenosas para perfusión continua.
Enferm Intensiva 2010 ;21:96-103.
3466 Journal B. Ribas Nicolau, E. P?rez Juan, S.M. Amor?s Cerd?, M.J. Ar?valo Rubert, M. Maqueda Palau.
Compatibilidad física del bicarbonato sódico con fármacos de uso frecuente en la unidad de cuidados intensivos
Enferm Intensiva 2011 ;22:78-82.
3539 Manufacturer Bivalirudin (Angiox®) - Summary of Product Characteristics.
The Medecines Company 2013
3540 Manufacturer Heparin sodium - Summary of Product Characteristics.
Wockhardt 2010
3823 Journal Juan E.P, Palau M.M, Cerd? S.A, Rubert M.A, Nicolau B.R.
Compatibilité physique de médicaments administrés dans l’unité de soins intensifs
Pharmactuel 2015 ; 48, 3 : 146-152.
3824 Journal Boudi S, Roy H, Forest JM, Leclair G.
Compatibilité physique de l'association amoxicilline-acide clavulanique en injection avec plusieurs autres médicaments lors d'une administration en Y.
Pharmactuel 2023 2023;56,3:91-98
4036 Journal Estan-Cerezo G, Matoses-Chirivella C, Soriano-Iriga L, Murcia-Lopez A.C, Rodrguez-Lucena F.J, Navarro-Ruiz A.
Stability and compatibility of ondansetron with haloperidol in parenteral admixtures.
EJHP 2017 ;25,4: 200-203.
4082 Journal Espinosa-Bosch M, Sanchez-Rojas F, Bosche-Ojeda C.
Stability of mixtures of ondansetron and haloperidol stored in infusors at different temperatures.
EJHP 2018 ; 25, e2
4366 Journal Estan-Cerezo G, Rodriguez-Lucena F.J, Matoses Chirivella C, Jiminez-Pulido I, Garcia-Monsalve A, Navarro-Ruiz A.
Midazolam and haloperidol for palliative sedation: physicochemical stability and compatibility of parenteral admixtures.
Braz J Pharm Sci 2019 ;55:e17351
4404 Poster Müller U, Haller F, Wiedemeier P, Steuer C.
Compatibility studies of seven commonly used drugs for parenteral administration in palliative care.
JFSPH 2019 2019
4433 Journal Ghazi I.M, El Nekidy W.S, Sood A, Dulku A, Patel R, Patel K.
Y-site Administration of Imipenem/Cilastatin/ Relebactam With Common Intravenous Medications
Clin Ther 2020 ; 42, 3: 475-485.
4435 Journal Hanifah S, Nugroho B.H, Chabib L.
Compatibility of acetaminophen with central nervous system medications during simulated Y-site injection.
Anaesthesiol Intensive Ther 2020 ; 52, 1: 23-27.
4603 Journal Vallée M, Barthélémy I, Friciu M, Pelletier E, Forest J.M, Benoit F, Leclair G.
Compatibility of Lactated Ringer’s Injection With 94 Selected Intravenous Drugs During Simulated Y-site Administration.
Hosp Pharm 2021 ; 56, 4: 228-234.
4650 Manufacturer Ceftobiprole (Zevtera 500 mg powder for concentrate for solution for infusion.) Summary of Product Characteristics, Advanz Pharma updated 4 aug 2021.
Advanz Pharma 2021
4742 Journal Macoviciuc M, Nguyen C, Forest J-M, Leclair G.
Compatibilité physique de l’acétaminophène injectable avec 102 autres médicaments lors d’une administration en Y.
Pharmactuel 2022 ; 55, 4: 247-255.

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