Last update :
19/11/2024
Local anesthetic   Bupivacaine hydrochloride  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Bicain Finland
Bucain Austria, Germany
Bucaine Saudi Arabia
Bupi Alleman Germany
Bupinest Colombia, Ecuador
Bupirop Ecuador
Bupisen Italy
Bupivacain Germany
Bupivacaina Chile, Spain
Bupivacaine Australia, Great Britain, Ireland, Morocco, Tunisia
Bupivan Chile, Germany
Buvacaina Mexico
Buvasin Turkey
Carbostesin Austria, Germany
Dolanaest Austria, Germany
Duracaine Argentina
Inibsacain Spain
Marcain Australia, Denmark, Egypt, Malaysia, New Zealand
Marcaine Belgium
Sensorcaine Canada
Sinebupiv Ecuador
Compatibility   injection   Compatibility : Bupivacaine hydrochloride              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
injection Bupivacaine hydrochloride 5 mg/ml
injection Caffeine 10 mg/ml
None 3964
Compatible
injection Bupivacaine hydrochloride 4 mg/ml
injection Diamorphine hydrochloride 0,1 mg/ml
Glucose 8% 2308
Compatible
injection Bupivacaine hydrochloride 20 mg/ml
injection Fentanyl citrate 25 µg/ml
Sodium chloride 0,9% 3131
Compatible
injection Bupivacaine hydrochloride 5 mg/ml
Ringer’s lactate solution 4603
Compatible
injection Bupivacaine hydrochloride 1.5 mg/ml
injection Diamorphine hydrochloride 0.02 mg/ml
Sodium chloride 0,9% 512
Compatible
injection Bupivacaine hydrochloride 1,250 mg/ml
injection Fentanyl citrate 20 µg/ml
Sodium chloride 0,9% 60
Compatible
injection Bupivacaine hydrochloride
injection Hyaluronidase
3184
Compatible
injection Bupivacaine hydrochloride 2,5 mg/ml
injection Hydromorphone hydrochloride 0,02 & 0,04 mg/ml
Sodium chloride 0,9% 1931
Compatible
injection Bupivacaine hydrochloride 20 mg/ml
injection Hydromorphone hydrochloride 25 mg/ml
Sodium chloride 0,9% 3131
Compatible
injection Bupivacaine hydrochloride 10 mg/ml
injection Hydromorphone hydrochloride 15 mg/ml
None 4200
Compatible
injection Bupivacaine hydrochloride 7,5 mg/ml
injection Hydromorphone hydrochloride 65 mg/ml
None 221
Compatible
injection Bupivacaine hydrochloride 0,625 & 1,25 mg/ml
injection Hydromorphone hydrochloride 0,02 & 0,1 mg/ml
Sodium chloride 0,9% 306
Compatible
injection Bupivacaine hydrochloride 1 & 2 mg/ml
injection Iohexol 60 mg I/ml
Sodium chloride 0,9% 529
Immediate precipitation Incompatible
injection Bupivacaine hydrochloride 5 mg/ml
injection Meropenem 50 mg/ml
Water for Injection 4319
Compatible
injection Bupivacaine hydrochloride 7,5 mg/ml
injection Morphine hydrochloride 0,2 mg/ml
Sodium chloride 0,9% 1885
Compatible
injection Bupivacaine hydrochloride 20 mg/ml
injection Morphine sulfate 25 mg/ml
Sodium chloride 0,9% 3131
Compatible
injection Bupivacaine hydrochloride 1 mg/ml
injection Morphine sulfate 0,05 mg/ml
Sodium chloride 0,9% 1276
Compatible
injection Bupivacaine hydrochloride 7,5 mg/ml
injection Morphine sulfate 129 mg/ml
None 221
Compatible
injection Bupivacaine hydrochloride 0,625 & 1,250 mg/ml
injection Morphine sulfate 0,1 & 0,5 mg/ml
Sodium chloride 0,9% 220
Compatible
injection Bupivacaine hydrochloride 5 mg/ml
injection Sugammadex 100 mg/ml
None 3372

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