Last update :
19/11/2024
Anticancer drug   Cisplatin  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Abiplatin Republic of South Africa
Accocit Mexico
Briplatin Japan
Cisplatex Brazil
Cisplatin Australia, Austria, Belgium, Canada, Saudi Arabia
Cisplatina Brazil
Cisplatine Belgium, France
Cisplatyl France, Greece, Saudi Arabia, Turkey
Citoplatino Argentina, Italy
Citoplax Brazil
Corsis Mexico
Insel Brazil
Neoplatin Spain
Pamifect India
Placis Spain, Turkey
Platamine Greece, Italy, Morocco, Tunisia
Platanovag Argentina
Platiblastin Austria
Platidiam Hungary, Poland
Platinex Germany, Great Britain, Italy
Platinol Austria, Belgium, Denmark, Finland, Greece, Luxembourg, Mexico, Netherlands, Sweden, Switzerland, United States of America
Platistil Spain
Platistine Belgium, Brazil, Luxembourg
Platosin Belgium, Egypt, Greece, Japan, Netherlands, Romania, Turkey, Venezuela
Pronto Platamine Italy
Zuridry Mexico
Compatibility   injection   Compatibility : Cisplatin              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Chemical instability Incompatible
injection Cisplatin
NaHCO3 3578
Compatible
injection Cisplatin 1 mg/ml
injection Allopurinol sodium 3 mg/ml
Sodium chloride 0,9% 307
Turbidity in 4 hours Incompatible
injection Cisplatin 1 mg/ml
injection Amifostine 10 mg/ml
Glucose 5% 3
Immediate precipitation Incompatible
injection Cisplatin 1 mg/ml
injection Amphotericin B cholesteryl sulfate complex 0.83 mg/ml
Glucose 5% 921
Compatible
injection Cisplatin 0,5 mg/ml
injection Caspofungin acetate 0,7 mg/ml
Sodium chloride 0,9% 2247
Chemical instability Incompatible
injection Cisplatin
Glucose 5% 3578
Chemical instability Incompatible
injection Cisplatin
injection Amikacin sulfate
3578
Chemical instability Incompatible
injection Cisplatin
injection Amphotericin B cholesteryl sulfate complex
3578
Compatible
injection Cisplatin 1 mg/ml
injection Anidulafungin 0.5 mg/ml
Glucose 5% 1982
Chemical instability Incompatible
injection Cisplatin
injection Atropine sulfate
3578
Compatible
injection Cisplatin 1 mg/ml
injection Aztreonam 40 mg/ml
Glucose 5% 99
Chemical instability Incompatible
injection Cisplatin
injection Bleomycin sulfate
3578
Chemical instability Incompatible
injection Cisplatin
injection Cefpirome sulfate
3578
Chemical instability Incompatible
injection Cisplatin
injection Chloroquine sulfate
3578
Compatible
injection Cisplatin 1 mg/ml
Parenteral nutrition (with lipids) 1415
Compatible
injection Cisplatin 1 mg/ml
injection Cladribine 0.5 mg/ml
NaCl 0,9% + antibacterial 1496
Compatible
injection Cisplatin 1 mg/ml
injection Cladribine 0.015 mg/ml
Sodium chloride 0,9% 1496
Compatible
injection Cisplatin 0,5 mg/ml
injection Doripenem 5 mg/ml
NaCl 0,9% or Glucose 5% 2262
Compatible
injection Cisplatin 1 mg/ml
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
Glucose 5% 251
Compatible
injection Cisplatin 1 mg/ml
injection Etoposide phosphate 5 mg/ml
Glucose 5% 1410
Compatible
injection Cisplatin 1 mg/ml
injection Fludarabine phosphate 1 mg/ml
Glucose 5% 492
Color change after 1 hour Incompatible
injection Cisplatin 1 mg/ml
Parenteral nutrition (binary mixture) 301
Chemical instability Incompatible
injection Cisplatin
injection Ephedrine sulfate
3578
Compatible
injection Cisplatin 0,2 mg/ml
injection Etoposide 0,2 & 0,4 mg/ml
Sodium chloride 0,9% 417
Compatible
injection Cisplatin 0,2 mg/ml
injection Etoposide 0,2 & 0,4 mg/ml
NaCl 0,45% Glucose 5% 417
Compatible
injection Cisplatin 1 mg/ml
injection Filgrastim 30 µg/ml
Glucose 5% 244
Chemical instability Incompatible
injection Cisplatin
injection Fluorouracil
3578
Unspecified incompatibility Incompatible
injection Cisplatin
injection Fluorouracil
3474
Chemical instability Incompatible
injection Cisplatin 0,5 mg/ml
injection Fluorouracil 10 mg/ml
Sodium chloride 0,9% 413
Chemical instability Incompatible
injection Cisplatin 0,2 mg/ml
injection Fluorouracil 1 mg/ml
Sodium chloride 0,9% 413
Immediate precipitation Incompatible
injection Cisplatin 1 mg/ml
injection Gallium nitrate 1 mg/ml
Sodium chloride 0,9% 91
Compatible
injection Cisplatin 1 mg/ml
injection Gemcitabine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1423
Chemical instability Incompatible
injection Cisplatin
injection Gentamicin sulfate
3578
Compatible
injection Cisplatin 0.05 & 1 mg/ml
injection Granisetron hydrochloride 1 mg/ml
Sodium chloride 0,9% 57
Compatible
injection Cisplatin 0.2 mg/ml
injection Hydroxyzine dihydrochloride 0.5 mg/ml
Sodium chloride 0,9% 331
Chemical instability Incompatible
injection Cisplatin
injection Isavuconazonium sulfate
3578
Chemical instability Incompatible
injection Cisplatin
injection Kanamycin sulfate
3578
Immediate precipitation Incompatible
injection Cisplatin 1 mg/ml
injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Compatible
injection Cisplatin 1 mg/ml
injection Linezolid 2 mg/ml
None 1925
Chemical instability Incompatible
injection Cisplatin
injection Magnesium sulfate
3578
Compatible
injection Cisplatin 1 mg/ml
injection Melphalan 0.1 mg/ml
Sodium chloride 0,9% 169
Unspecified incompatibility Incompatible
injection Cisplatin
injection Mesna
3602
Unspecified incompatibility Incompatible
injection Cisplatin
injection Mesna
4084
Chemical instability Incompatible
injection Cisplatin
injection Morphine sulfate
3578
Chemical instability Incompatible
injection Cisplatin
injection Neostigmine methylsulfate
3578
Chemical instability Incompatible
injection Cisplatin
injection Netilmicin sulfate
3578
Compatible
injection Cisplatin 1 mg/ml
injection Ondansetron hydrochloride 1 mg/ml
Sodium chloride 0,9% 334
Compatible
injection Cisplatin < 0,48 mg/ml
injection Ondansetron hydrochloride 0,016 >> 0,16 mg/ml
3574
Compatible
injection Cisplatin 0,2 mg/ml
injection Ondansetron hydrochloride 0,48 mg/ml
Sodium chloride 0,9% 53
Compatible
injection Cisplatin 0,455 mg/ml
injection Ondansetron hydrochloride 1,091 mg/ml
Sodium chloride 0,9% 53
Compatible
injection Cisplatin 1 mg/ml
injection Paclitaxel 1.2 mg/ml
Glucose 5% 85
Chemical instability Incompatible
injection Cisplatin
injection Paclitaxel
3578
Compatible
injection Cisplatin 0,2 mg/ml
injection Paclitaxel 0,3 & 1,2 mg/ml
Sodium chloride 0,9% 872
Compatible
injection Cisplatin 0,5 mg/ml
injection Palonosetron hydrochloride 50 µg/ml
Sodium chloride 0,9% 1950
Chemical instability Incompatible
injection Cisplatin
injection Pemetrexed diarginine
4589
Compatible
injection Cisplatin 0.5 mg/ml
injection Pemetrexed disodium 20 mg/ml
Sodium chloride 0,9% 1953
Precipitation after 1 hour Incompatible
injection Cisplatin 1 mg/ml
injection Piperacillin sodium / tazobactam 40/5 mg/ml
Glucose 5% 81
Compatible
injection Cisplatin 1 mg/ml
injection Propofol 10 mg/ml
None 300
Instability of the emulsion after 24 hours Incompatible
injection Cisplatin 0.3 mg/ml
injection Propofol
660
Chemical instability Incompatible
injection Cisplatin
injection Protamine sulfate
3578
Chemical instability Incompatible
injection Cisplatin
injection Salbutamol sulfate
3578
Compatible
injection Cisplatin 1 mg/ml
injection Sargramostim 10 µg/ml
Sodium chloride 0,9% 335
Unspecified incompatibility Incompatible
injection Cisplatin
injection Sodium bicarbonate 50 mg/ml
4084
Chemical instability Incompatible
injection Cisplatin
injection Sodium bicarbonate
3578
Unspecified incompatibility Incompatible
injection Cisplatin
injection Sodium thiosulfate
4084
Chemical instability Incompatible
injection Cisplatin
injection Streptomycin sulfate
3578
Compatible
injection Cisplatin 1 mg/ml
injection Teniposide 0.1 mg/ml
Glucose 5% 905
Chemical instability Incompatible
injection Cisplatin
injection Terbutaline sulfate
3578
Turbidity in 4 hours Incompatible
injection Cisplatin 1 mg/ml
injection Thiotepa 1 mg/ml
Glucose 5% 249
Chemical instability Incompatible
injection Cisplatin
injection Tobramycin sulfate
3578
Compatible
injection Cisplatin 0.168 mg/ml
injection Topotecan 0.056 mg/ml
NaCl 0,9% or Glucose 5% 1026
Chemical instability Incompatible
injection Cisplatin
injection Vinblastine sulfate
3578
Chemical instability Incompatible
injection Cisplatin
injection Vincristine sulfate
3578
Chemical instability Incompatible
injection Cisplatin
injection Vincristine sulfate liposome
3578
Chemical instability Incompatible
injection Cisplatin
injection Vindesine sulfate
3578
Compatible
injection Cisplatin 1 mg/ml
injection Vinorelbine tartrate 1 mg/ml
Sodium chloride 0,9% 84

  Mentions Légales