Last update :
18/04/2024
References   References 4762  
Type : Journal
Web link : https://doi.org/10.1136/ejhpharm-2020-002597

Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Knoll L, Kraemer I, Thiesen J.
Title : Physicochemical stability of carmustine-containing medicinal products after reconstitution and after dilution to ready-to-administer infusion solutions stored refrigerated or at room temperature
Reference : EJHP ; 30, 1: 11-16. 2023

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
Stability indicating capability inadequately assessed
Method not shown but the article refers to a validated method
Degradation products not observed in real conditions

List of drugs
InjectionCarmustine Anticancer drug
Stability in solutions Glass Specific solvent 3,3 mg/ml 2-8°C Protect from light
24 Hour
Stability in solutions Polyolefine Glucose 5% 0,2 mg/ml 2-8°C Protect from light
48 Hour
Stability in solutions Polyolefine Glucose 5% 0,2 mg/ml 22°C Protect from light
6 Hour
Stability in solutions Polyolefine Glucose 5% 1 mg/ml 2-8°C Protect from light
48 Hour
Stability in solutions Polyolefine Glucose 5% 1 mg/ml 22°C Protect from light
8.5 Hour

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