Last update :
19/09/2022
References   References 4673  
Type : Journal
Web link : 10.3390/pharmaceutics14010118

Research teams : Clermont-Ferrand - Université d’Auvergne, Faculté de Pharmacie
Authors : Barrieu M, Chennell P, Yessaad M, Bouattour Y, Wasiak M, Jouannet M, Le Basle Y, Sautou V.
Title : Physicochemical Stability of a Novel Tacrolimus Ophtalmic Formulation for the Treatment of Ophtalmic Inflammatory Diseases.
Reference : Pharmaceutics ;14,1:118 2022

Level of Evidence : 
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement Measurement of osmolality 
Comments : 

List of drugs
Oral solutionTacrolimus Immunosuppressant
Stability in solutions Novelia® Powder 1 mg
Kolliphor EL® 80 mg
Ethanol 23,8 µL
NaH2PO4 2,45 mg
Na2HPO4 0,181 mg
Sodium hyaluronate 7,35 mg
NaCl 0.9% >> 5 mL
2-8°C Not specified
270 Day
Stability in solutions Novelia® Powder 5 mg
Kolliphor EL® 400 mg
Ethanol 119 µL
NaH2PO4 2,25 mg
Na2HPO4 0,167 mg
Sodium hyaluronate 6,75 mg
NaCl 0.9% >> 5 mL
2-8°C Not specified
270 Day

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