Last update :
19/09/2022
References   References 4645  
Type : Journal
Web link : 10.1093/jacamr/dlab141

Research teams : Birmingham - Sandwell and West Birmingham NHS Trust, Birmingham
Authors : Jamieson C, Drummond F, Hill T, Ozolina L, Gilchrist M, Seaton R.A, Santillo M, Wilkinson A-S, Allwood M.C.
Title : Assessment of ceftolozane/tazobactam stability in elastomeric devices and suitability for continuous infusion via outpatient parenteral antimicrobial therapy.
Reference : JAC Antimicrob Resist 2021

Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionCeftolozane / tazobactam Antibiotic
Stability in solutions Silicone elastomer Sodium chloride 0,9% 13.33/6.66 mg/ml 32°C Protect from light
18 Hour
Stability in solutions Silicone elastomer Sodium chloride 0,9% 13.33/6.66 mg/ml 8°C Protect from light
8 Day
Stability in solutions Silicone elastomer Sodium chloride 0,9% 3.33/1.66 mg/ml 32°C Protect from light
18 Hour
Stability in solutions Silicone elastomer Sodium chloride 0,9% 3.33/1.66 mg/ml 8°C Protect from light
8 Day
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 13.33/6.66 mg/ml 32°C Protect from light
18 Hour
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 13.33/6.66 mg/ml 8°C Protect from light
8 Day
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 3.33/1.66 mg/ml 32°C Protect from light
18 Hour
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 3.33/1.66 mg/ml 8°C Protect from light
8 Day

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