Last update :
29/10/2024
References   References 3166  
Type : Journal
Web link : http://www.cjhp-online.ca/index.php/cjhp/article/view/963

Research teams : Vancouver - Children\'s and Women\'s Health Center of British Columbia
Authors : Strong DK, Decarie D, Ensom MHH.
Title : Stability of Levothyroxine in Sodium Chloride for IV Administration.
Reference : Can J Hosp Pharm ; 63, 6: 437-443. 2011

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
injectionLevothyroxine Hormone
Factors which affect stability Storage Light Induces Degradation
Factors which affect stability Concentration Reduced concentration Induces Enhanced stability
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,4 µg/ml 25°C Protect from light
18 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,4 µg/ml 25°C Light
16 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 2 µg/ml 25°C Protect from light
12 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 2 µg/ml 25°C Light
6 Hour

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