Last update :
27/11/2024
References   References 1953  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/61/21/2289

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Saenz CA, Ogundele AB, Ingram DS.
Title : Physical compatibility of pemetrexed disodium with other drugs during simulated Y-site administration.
Reference : Am J Health-Syst Pharm ; 61: 2289-2293. 2004

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
injectionAciclovir sodium Antiviral
Compatible 7 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionAmifostine Cytoprotective
Compatible 10 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionAminophylline Various
Compatible 2.5 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionAmphotericin B Antifungal
Incompatible 0.6 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionAmpicillin sodium Antibiotic
Compatible 20 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionAmpicillin sodium - sulbactam sodium Antibiotic
Compatible 20/10 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionAztreonam Antibiotic
Compatible 40 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionBumetanide Diuretic
Compatible 0.04 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionBuprenorphine hydrochloride Analgesic
Compatible 0.04 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionButorphanol tartrate Analgesic
Compatible 0.04 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionCalcium gluconate Electrolyte
Incompatible 40 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionCarboplatin Anticancer drug
Compatible 5 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionCefazolin sodium Antibiotic
Incompatible 20 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionCefotaxime sodium Antibiotic
Incompatible 20 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionCefoxitin sodium Antibiotic
Incompatible 20 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionCeftazidime Antibiotic
Incompatible 40 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionCeftizoxime sodium Antibiotic
Compatible 20 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionCeftriaxone disodium Antibiotic
Compatible 20 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionCefuroxime sodium Antibiotic
Compatible 30 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionCimetidine hydrochloride Antihistamine (H2)
Compatible 12 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionCiprofloxacin lactate Antibiotic
Incompatible 2 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionCisplatin Anticancer drug
Compatible 0.5 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionClindamycin phosphate Antibiotic
Compatible 10 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionCo-trimoxazole Antibiotic
Compatible 0.8/4 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionCyclophosphamide Anticancer drug
Compatible 10 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionCytarabine Anticancer drug
Compatible 50 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionDexrazoxane hydrochloride Cytoprotective
Compatible 5 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionDobutamine hydrochloride Cardiotonic
Incompatible 4 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionDocetaxel Anticancer drug
Compatible 0.8 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionDopamine hydrochloride Cardiotonic
Compatible 3.2 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionDoxorubicin hydrochloride Anticancer drug
Incompatible 1 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionDoxycycline hyclate Antibiotic
Incompatible 1 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionDroperidol Neuroleptic
Incompatible 2.5 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionEnalaprilate Antihypertensive
Compatible 0.1 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionFamotidine Antihistamine (H2)
Compatible 2 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionFluorouracil Anticancer drug
Compatible 16 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionFolinate calcium Cytoprotective
Compatible 2 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionGanciclovir sodium Antiviral
Compatible 20 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionGemcitabine hydrochloride Anticancer drug
Incompatible 10 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionGentamicin sulfate Antibiotic
Incompatible 5 mg/ml + injectionPemetrexed disodium 20 mg/ml
injectionGranisetron hydrochloride Antiemetic
Compatible 0.05 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionHaloperidol lactate Neuroleptic
Compatible 0.2 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionHeparin sodium Anticoagulant
Compatible 100 UI/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionHydromorphone hydrochloride Analgesic
Compatible 0.5 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionHydroxyzine dihydrochloride Anxiolytic
Compatible 2 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionIfosfamide Anticancer drug
Compatible 20 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionIrinotecan Anticancer drug
Incompatible 1 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionLorazepam Anxiolytic
Compatible 0.5 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionMannitol Various
Compatible 150 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionMesna Cytoprotective
Compatible 10 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 5 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionMetronidazole Antiparasitic
Incompatible 5 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionMinocycline hydrochloride Antibiotic
Incompatible 0.2 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionMitoxantrone dihydrochloride Anticancer drug
Incompatible 0.5 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionMorphine sulfate Analgesic
Compatible 15 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionNalbuphine hydrochloride Antidote
Incompatible 10 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionOndansetron hydrochloride Antiemetic
Incompatible 1 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionPaclitaxel Anticancer drug
Compatible 0.6 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionPemetrexed disodium Anticancer drug
Compatible 20 mg/ml + injectionAciclovir sodium 7 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionAmifostine 10 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionAmikacin sulfate 5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionAminophylline 2.5 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionAmphotericin B 0.6 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionAmpicillin sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionAmpicillin sodium - sulbactam sodium 20/10 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionAztreonam 40 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionBumetanide 0.04 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionBuprenorphine hydrochloride 0.04 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionButorphanol tartrate 0.04 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionCalcium gluconate 40 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionCarboplatin 5 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionCefazolin sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionCefotaxime sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionCefoxitin sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionCeftazidime 40 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionCeftizoxime sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionCeftriaxone disodium 20 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionCefuroxime sodium 30 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionCimetidine hydrochloride 12 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionCisplatin 0.5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionClindamycin phosphate 10 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionCo-trimoxazole 0.8/4 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionCyclophosphamide 10 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionCytarabine 50 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionDexamethasone sodium phosphate 1 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionDexrazoxane hydrochloride 5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionDiphenhydramine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionDobutamine hydrochloride 4 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionDocetaxel 0.8 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionDopamine hydrochloride 3.2 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionDoxorubicin hydrochloride 1 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionDoxycycline hyclate 1 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionDroperidol 2.5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionEnalaprilate 0.1 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionFamotidine 2 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionFluconazole 2 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionFluorouracil 16 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionFolinate calcium 2 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionGanciclovir sodium 20 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionGemcitabine hydrochloride 10 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionGentamicin sulfate 5 mg/ml
Compatible 20 mg/ml + injectionGranisetron hydrochloride 0.05 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionHaloperidol lactate 0.2 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionHeparin sodium 100 UI/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionHydromorphone hydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionHydroxyzine dihydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionIfosfamide 20 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionIrinotecan 1 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionLorazepam 0.5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionMannitol 150 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionMesna 10 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionMethylprednisolone sodium succinate 5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionMetoclopramide hydrochloride 5 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionMetronidazole 5 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionMinocycline hydrochloride 0.2 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionMitoxantrone dihydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionMorphine sulfate 15 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionNalbuphine hydrochloride 10 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionOndansetron hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionPaclitaxel 0.6 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionPethidine hydrochloride 10 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionPotassium chloride 100 mEq/l + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionProchlorperazine edysilate 0.5 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionPromethazine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionRanitidine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionSodium bicarbonate 84 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionTicarcillin / clavulanic acid 31 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionTobramycin sulfate 5 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + injectionTopotecan 0.1 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionVancomycin hydrochloride 10 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionVinblastine sulfate 0.12 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionVincristine sulfate 0.05 mg/ml + Sodium chloride 0,9%
Compatible 20 mg/ml + injectionZidovudine 4 mg/ml + Sodium chloride 0,9%
injectionPethidine hydrochloride Analgesic
Compatible 10 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionPotassium chloride Electrolyte
Compatible 100 mEq/l + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionProchlorperazine edysilate Neuroleptic
Incompatible 0.5 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionPromethazine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionSodium bicarbonate Electrolyte
Compatible 84 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionTicarcillin / clavulanic acid Antibiotic
Compatible 31 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionTobramycin sulfate Antibiotic
Incompatible 5 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionTopotecan Anticancer drug
Incompatible 0.1 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionVancomycin hydrochloride Antibiotic
Compatible 10 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionVinblastine sulfate Anticancer drug
Compatible 0.12 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionVincristine sulfate Anticancer drug
Compatible 0.05 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%
injectionZidovudine Antiviral
Compatible 4 mg/ml + injectionPemetrexed disodium 20 mg/ml + Sodium chloride 0,9%

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