Last update :
27/11/2024
References   References 176  
Type : Journal

Research teams : Sacramento - University of California Davis medical center, Department of Pharmacy Services
Authors : Mantong ML, Marquardt ED.
Title : Visual compatibility of midazolam hydrochloride with selected drugs during simulated Y-site injection.
Reference : Am J Health-Syst Pharm ; 52: 2567-2568. 1995

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionAmpicillin sodium Antibiotic
Incompatible 20 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionCalcium gluconate Electrolyte
Compatible 100 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionCefazolin sodium Antibiotic
Compatible 20 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionCefotaxime sodium Antibiotic
Compatible 20 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionCeftazidime Antibiotic
Incompatible 20 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionCefuroxime sodium Antibiotic
Incompatible 15 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionCimetidine hydrochloride Antihistamine (H2)
Compatible 15 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionClindamycin phosphate Antibiotic
Compatible 9 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionDexamethasone sodium phosphate Anti-inflammatory
Incompatible 4 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionDigoxin Cardiotonic
Compatible 100 µg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionDobutamine hydrochloride Cardiotonic
Incompatible 2 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionDopamine hydrochloride Cardiotonic
Compatible 1,6 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionFentanyl citrate Analgesic
Compatible 50 µg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionFurosemide Diuretic
Incompatible 10 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionGentamicin sulfate Antibiotic
Compatible 10 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 40 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionMidazolam hydrochloride Anxiolytic
Factors which affect stability Solvent NaHCO3 Induces Degradation
Incompatible 1 mg/ml + NaHCO3
Incompatible 1 mg/ml + injectionAmpicillin sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionCalcium gluconate 100 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionCefazolin sodium 20 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionCefotaxime sodium 20 mg/ml + Glucose 5%
Incompatible 1 mg/ml + injectionCeftazidime 20 mg/ml + Glucose 5%
Incompatible 1 mg/ml + injectionCefuroxime sodium 15 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionCimetidine hydrochloride 15 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionClindamycin phosphate 9 mg/ml + Glucose 5%
Incompatible 1 mg/ml + injectionDexamethasone sodium phosphate 4 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionDigoxin 100 µg/ml + Glucose 5%
Incompatible 1 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionDopamine hydrochloride 1,6 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionFentanyl citrate 50 µg/ml + Glucose 5%
Incompatible 1 mg/ml + injectionFurosemide 10 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionGentamicin sulfate 10 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionMethylprednisolone sodium succinate 40 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionMetronidazole 5 mg/ml + Glucose 5%
Incompatible 1 mg/ml + injectionNafcillin sodium 20 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionNitroglycerin 0,2 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionNitroprusside sodium 0,2 mg/ml + Glucose 5%
Incompatible 1 mg/ml + injectionSodium bicarbonate 84 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionTheophylline 1,6 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionTobramycin sulfate 10 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionVancomycin hydrochloride 5 mg/ml + Glucose 5%
injectionNafcillin sodium Antibiotic
Incompatible 20 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionNitroglycerin Vasodilator
Compatible 0,2 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionNitroprusside sodium Vasodilator
Compatible 0,2 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionSodium bicarbonate Electrolyte
Incompatible 84 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionTheophylline Various
Compatible 1,6 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionTobramycin sulfate Antibiotic
Compatible 10 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%
injectionVancomycin hydrochloride Antibiotic
Compatible 5 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Glucose 5%

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