Last update :
19/11/2024
References   References 172  
Type : Journal

Research teams : Utrecht - Faculty of pharmacy, State university of Utrecht
Authors : Beijnen JH, van Gijn R, Challa EE, Kaijser GP, Underberg WJM.
Title : Chemical stability of two sterile, parenteral formulations of cyclophosphamide (Endoxan) after reconstitution and dilution in commonly used infusion fluids.
Reference : J Parenter Sci Technol ; 46: 111-116. 1992

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Degradation products quantified but not identified

List of drugs
injectionCyclophosphamide Anticancer drug
Factors which affect stability Temperature Increase Induces Degradation
Stability in solutions Glass Water for Injection 20 mg/ml 4°C Protect from light
7 Day
Stability in solutions Glass NaCl 0,9% or Glucose 5% 1 mg/ml 25°C Protect from light
7 Day
Stability in solutions Glass NaCl 0,9% or Glucose 5% 1 mg/ml 4°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride Water for Injection 20 mg/ml 4°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 mg/ml 4°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml 25°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride Glucose 5% 1 mg/ml 25°C Protect from light
2 Day

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