Last update :
19/11/2024
References   References 1201  
Type : Journal

Research teams : Philadelphia - Smith Kline and French Laboratories
Authors : Yuhas EM, Lofton FT, Rosenberg HA, Mayron D, Baldinus JG.
Title : Cimetidine hydrochloride compatibility III: Room temperature stability in drug admixtures.
Reference : Am J Hosp Pharm ; 38: 1919-1922. 1981

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
injectionAcetazolamide Diuretic
Compatible 5 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionAmikacin sulfate Antibiotic
Compatible 2.5 mg/ml + injectionCimetidine hydrochloride 1.5 mg/ml + Glucose 5%
injectionAmphotericin B Antifungal
Incompatible 0.1 mg/ml + injectionCimetidine hydrochloride 0.6 mg/ml + Glucose 5%
injectionAmpicillin sodium Antibiotic
Compatible 1 mg/ml + injectionCimetidine hydrochloride 1.2 & 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionCefalotin sodium Antibiotic
Compatible 3 mg/ml + injectionCimetidine hydrochloride 1.2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 3 mg/ml + injectionCimetidine hydrochloride 5 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 10 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionCefamandole nafate Antibiotic
Compatible 1 mg/ml + injectionCimetidine hydrochloride 0.3 mg/ml + Glucose 5%
Incompatible 20 mg/ml + injectionCimetidine hydrochloride 6 mg/ml + Glucose 5%
injectionCefazolin sodium Antibiotic
Incompatible 10 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionCimetidine hydrochloride 1.2 & 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionCefoxitin sodium Antibiotic
Compatible 10 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionChlorothiazide sodium Diuretic
Compatible 5 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionCimetidine hydrochloride Antihistamine (H2)
Compatible 3 mg/ml + injectionAcetazolamide 5 mg/ml + Glucose 5%
Compatible 1.5 mg/ml + injectionAmikacin sulfate 2.5 mg/ml + Glucose 5%
Incompatible 0.6 mg/ml + injectionAmphotericin B 0.1 mg/ml + Glucose 5%
Compatible 1.2 & 5 mg/ml + injectionAmpicillin sodium 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1.2 mg/ml + injectionCefalotin sodium 3 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 5 mg/ml + injectionCefalotin sodium 3 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 3 mg/ml + injectionCefalotin sodium 10 mg/ml + Glucose 5%
Incompatible 6 mg/ml + injectionCefamandole nafate 20 mg/ml + Glucose 5%
Compatible 0.3 mg/ml + injectionCefamandole nafate 1 mg/ml + Glucose 5%
Incompatible 3 mg/ml + injectionCefazolin sodium 10 mg/ml + Glucose 5%
Compatible 1.2 & 5 mg/ml + injectionCefazolin sodium 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 3 mg/ml + injectionCefoxitin sodium 10 mg/ml + Glucose 5%
Compatible 3 mg/ml + injectionChlorothiazide sodium 5 mg/ml + Glucose 5%
Compatible 1.2 & 5 mg/ml + injectionClindamycin phosphate 1.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 3 mg/ml + injectionColistin mesilate sodium 1.5 mg/ml + Glucose 5%
Compatible 3 mg/ml + injectionDexamethasone sodium phosphate 0.04 mg/ml + Glucose 5%
Compatible 3 mg/ml + injectionDigoxin 2.5 µg/ml + Glucose 5%
Compatible 3 mg/ml + injectionEpinephrine hydrochloride 0.1 µg/ml + Glucose 5%
Compatible 3 mg/ml + injectionErythromycin lactobionate 5 mg/ml + Sodium chloride 0,9%
Compatible 3 mg/ml + injectionEthacrynate sodium 0.5 mg/ml + Glucose 5%
Compatible 3 mg/ml + injectionFurosemide 0.4 mg/ml + Glucose 5%
Compatible 3 mg/ml + injectionGentamicin sulfate 0.8 mg/ml + Glucose 5%
Compatible 1.2 & 5 mg/ml + injectionGentamicin sulfate 0.08 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1.2 & 5 mg/ml + injectionInsulin 0.1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 3 mg/ml + injectionIsoprenaline hydrochloride 0.02 mg/ml + Glucose 5%
Compatible 3 mg/ml + injectionLidocaine hydrochloride 1.25 mg/ml + Glucose 5%
Compatible 3 mg/ml + injectionLincomycin 6 mg/ml + Glucose 5%
Compatible 3 mg/ml + injectionMetaraminol 1 mg/ml + Glucose 5%
Compatible 3 mg/ml + injectionMethylprednisolone sodium succinate 0.4 mg/ml + Glucose 5%
Compatible 3 mg/ml + injectionNitroprusside sodium 0.5 mg/ml + Glucose 5%
Compatible 3 mg/ml + injectionNorepinephrine bitartrate 0.04 mg/ml + Glucose 5%
Compatible 1.2 & 5 mg/ml + injectionPenicillin G potassium 0.0024 MUI/ml + NaCl 0,9% or Glucose 5%
Compatible 3 mg/ml + injectionPhytomenadione 0.1 mg/ml + Glucose 5%
Compatible 1.2 mg/ml + injectionPotassium chloride 20 & 80 mEq/l + NaCl 0,9% or Glucose 5%
Compatible 3 mg/ml + injectionProtamine hydrochloride 0.5 UI/ml + Glucose 5%
Compatible 3 mg/ml + injectionQuinidine gluconate 3.2 mg/ml + Glucose 5%
Compatible 3 mg/ml + injectionVancomycin hydrochloride 5 mg/ml + Glucose 5%
injectionClindamycin phosphate Antibiotic
Compatible 1.2 mg/ml + injectionCimetidine hydrochloride 1.2 & 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionColistin mesilate sodium Antibiotic
Compatible 1.5 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 0.04 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionDigoxin Cardiotonic
Compatible 2.5 µg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 0.1 µg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionErythromycin lactobionate Antibiotic
Compatible 5 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Sodium chloride 0,9%
injectionEthacrynate sodium Diuretic
Compatible 0.5 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionFurosemide Diuretic
Compatible 0.4 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionGentamicin sulfate Antibiotic
Compatible 0.8 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
Compatible 0.08 mg/ml + injectionCimetidine hydrochloride 1.2 & 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionInsulin Glucose-lowering
Compatible 0.1 UI/ml + injectionCimetidine hydrochloride 1.2 & 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionIsoprenaline hydrochloride Beta-stimulant
Compatible 0.02 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionLidocaine hydrochloride Local anesthetic
Compatible 1.25 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionLincomycin Antibiotic
Compatible 6 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionMetaraminol Sympathomimetic
Compatible 1 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 0.4 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionNitroprusside sodium Vasodilator
Compatible 0.5 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 0.04 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionPenicillin G potassium Antibiotic
Compatible 0.0024 MUI/ml + injectionCimetidine hydrochloride 1.2 & 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionPhytomenadione Vitamin
Compatible 0.1 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionPotassium chloride Electrolyte
Compatible 20 & 80 mEq/l + injectionCimetidine hydrochloride 1.2 mg/ml + NaCl 0,9% or Glucose 5%
injectionProtamine hydrochloride Antidote
Compatible 0.5 UI/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionQuinidine gluconate Anti-arrhythmic
Compatible 3.2 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%
injectionVancomycin hydrochloride Antibiotic
Compatible 5 mg/ml + injectionCimetidine hydrochloride 3 mg/ml + Glucose 5%

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