Last update :
29/10/2024
Anticancer drug   Doxorubicin hydrochloride  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Adriacept Germany
Adriamycin Australia, Austria, Canada, Denmark, Finland, Norway, United States of America
Adriblastin Austria, Switzerland
Adriblastina Belgium, Brazil, Croatia, Greece, Italy, Poland, Slovenia, Turkey
Adriblastine France, Greece
Adrimedac Germany
Biorub Brazil
Biorubina Poland
Dicladox Argentina
Doxolem Brazil
Doxorubicine France, Switzerland
Doxorubin Belgium, Greece
Farmiblastina Spain
Rastocin Poland
Robodoxo Germany
Compatibility   injection   Compatibility : Doxorubicin hydrochloride              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Immediate turbidity Incompatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Allopurinol sodium 3 mg/ml
Sodium chloride 0,9% 307
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Amifostine 10 mg/ml
Glucose 5% 3
Immediate precipitation Incompatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Amphotericin B cholesteryl sulfate complex 0.83 mg/ml
Glucose 5% 921
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Anidulafungin 0.5 mg/ml
Glucose 5% 1982
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Aztreonam 40 mg/ml
Glucose 5% 99
Compatible
injection Doxorubicin hydrochloride 1 mg/ml
injection Caspofungin acetate 0,7 mg/ml
Sodium chloride 0,9% 2247
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Cladribine 0.015 mg/ml
Sodium chloride 0,9% 1496
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Cladribine 0.5 mg/ml
NaCl 0,9% + antibacterial 1496
Unspecified incompatibility Incompatible
injection Doxorubicin hydrochloride
injection Dexamethasone sodium phosphate
3668
Compatible
injection Doxorubicin hydrochloride 1 mg/ml
injection Doripenem 5 mg/ml
NaCl 0,9% or Glucose 5% 2262
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Droperidol 2,5 mg/ml
763
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Etoposide phosphate 5 mg/ml
Glucose 5% 1410
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Filgrastim 30 µg/ml
Glucose 5% 244
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Fludarabine phosphate 1 mg/ml
Glucose 5% 492
Chemical instability Incompatible
injection Doxorubicin hydrochloride
injection Fluorouracil
3645
Unspecified incompatibility Incompatible
injection Doxorubicin hydrochloride
injection Fluorouracil
3474
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Fluorouracil 50 mg/ml
763
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Folinate calcium 10 mg/ml
763
Immediate precipitation Incompatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Furosemide 10 mg/ml
763
Immediate precipitation Incompatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Gallium nitrate 1 mg/ml
Sodium chloride 0,9% 91
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Gemcitabine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1423
Subvisual incompatibility Incompatible
injection Doxorubicin hydrochloride 0.2 mg/ml
injection Granisetron hydrochloride 1 mg/ml
Water for Injection 57
Unspecified incompatibility Incompatible
injection Doxorubicin hydrochloride
injection Heparin sodium
3540
Immediate precipitation Incompatible
injection Doxorubicin hydrochloride
injection Heparin sodium
3645
Immediate precipitation Incompatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Heparin sodium 1000 UI/ml
763
Immediate precipitation Incompatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Linezolid 2 mg/ml
None 1925
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Melphalan 0.1 mg/ml
Sodium chloride 0,9% 169
Immediate instability of the emulsion Incompatible
injection Doxorubicin hydrochloride 2 mg/ml
Parenteral nutrition (with lipids) 1415
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Methotrexate sodium 25 mg/ml
763
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Metoclopramide hydrochloride 5 mg/ml
763
Loss of turbidity Incompatible
injection Doxorubicin hydrochloride 2 mg/ml
Parenteral nutrition (binary mixture) 301
Compatible
injection Doxorubicin hydrochloride 0.4 mg/ml
injection Methotrexate sodium 30 mg/ml
Sodium chloride 0,9% 150
Unspecified incompatibility Incompatible
injection Doxorubicin hydrochloride
injection Mitomycin
4471
Chemical instability Incompatible
injection Doxorubicin hydrochloride
injection Mitomycin
3128
Unspecified incompatibility Incompatible
injection Doxorubicin hydrochloride
injection Morphine sulfate
3531
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Ondansetron hydrochloride 0,03 mg/ml
Glucose 5% 184
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Ondansetron hydrochloride 0,016 >> 0,16 mg/ml
Water for Injection 3574
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Ondansetron hydrochloride 1 mg/ml
Sodium chloride 0,9% 334
Compatible
injection Doxorubicin hydrochloride 0,1 mg/ml
injection Ondansetron hydrochloride 0,03 mg/ml
Glucose 5% 184
Compatible
injection Doxorubicin hydrochloride 0,1 mg/ml
injection Ondansetron hydrochloride 0,3 mg/ml
Glucose 5% 184
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Ondansetron hydrochloride 0,3 mg/ml
Glucose 5% 184
Compatible
injection Doxorubicin hydrochloride 1 mg/ml
injection Oxaliplatin 0,5 mg/ml
Glucose 5% 1662
Compatible
injection Doxorubicin hydrochloride 15 mg/ml
injection Oxaliplatin 200 mg/ml
Glucose 5% 3706
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Paclitaxel 1.2 mg/ml
Glucose 5% 85
Compatible
injection Doxorubicin hydrochloride 0,2 mg/ml
injection Paclitaxel 0,3 & 1,2 mg/ml
NaCl 0,9% or Glucose 5% 1286
Compatible
injection Doxorubicin hydrochloride 1 mg/ml
injection Palonosetron hydrochloride 50 µg/ml
Glucose 5% 1955
Color change Incompatible
injection Doxorubicin hydrochloride 1 mg/ml
injection Pemetrexed disodium 20 mg/ml
Sodium chloride 0,9% 1953
Immediate turbidity Incompatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Piperacillin sodium / tazobactam 40/5 mg/ml
Glucose 5% 81
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Propofol 10 mg/ml
None 300
Color change Incompatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Propofol
660
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Sargramostim 10 µg/ml
Sodium chloride 0,9% 335
Precipitation after 4 hours Incompatible
injection Doxorubicin hydrochloride 0.4 mg/ml
injection Sodium bicarbonate
NaHCO3 150
Precipitation after 4 hours Incompatible
injection Doxorubicin hydrochloride 0.4 mg/ml
injection Sodium bicarbonate 14 mg/ml
None 150
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Teniposide 0.1 mg/ml
Glucose 5% 905
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Thiotepa 1 mg/ml
Glucose 5% 249
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Topotecan 0.056 mg/ml
NaCl 0,9% or Glucose 5% 1026
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Vinblastine sulfate 1 mg/ml
763
Compatible
injection Doxorubicin hydrochloride 1,4 mg/ml
injection Vincristine sulfate 0,033 mg/ml
NaCl 0,45% Glucose 2,5% 408
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Vincristine sulfate 1 mg/ml
763
Compatible
injection Doxorubicin hydrochloride 1,4 mg/ml
injection Vincristine sulfate 0,033 mg/ml
Sodium chloride 0,9% 408
Compatible
injection Doxorubicin hydrochloride 1,67 mg/ml
injection Vincristine sulfate 0,036 mg/ml
Sodium chloride 0,9% 32
Compatible
injection Doxorubicin hydrochloride 2 mg/ml
injection Vinorelbine tartrate 1 mg/ml
Sodium chloride 0,9% 84

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