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Antiemetic   Granisetron hydrochloride  
injection
Oral solution
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Axigran Germany, Saudi Arabia
Cadigran India
Cetrexon Colombia
Em Ex Egypt
Emegran India
Emetril Turkey
Grandem India
Granic Iran
Granicip India
Graniset India
Granisetrom Portugal
Granisetron Belgium, Canada, Chile, Ecuador, Egypt, Great Britain, Mexico, Peru, Romania, Saudi Arabia, Spain, Sweden, United States of America
Granitero Portugal
Granitron Austria
Granon India
Granytril India
Gratil Iran
Gratryl Turkey
Helminar Peru
Kevatril Germany
Kytril Australia, Austria, Belgium, Brazil, Chile, Colombia, Denmark, Ecuador, Egypt, Finland, Germany, Great Britain, Greece, Hungary, Iran, Ireland, Italy, Japan, Luxembourg, Malaysia, Mexico, Morocco, Netherlands, Peru, Poland, Portugal, Saudi Arabia, Spain, Sweden, Switzerland, Tunisia, Turkey, United Arab Emirates, Venezuela
Manotrox Mexico
Neoset Turkey
Ribosetron Germany
Rubrum Venezuela
Suliftop Peru
Synarex Turkey
Tentratec Mexico
Tigron Turkey
Travigan Mexico
Trilemes Mexico
Vitasetron Turkey
Stability of mixtures   injection   Stability of mixtures : Granisetron hydrochloride     
Container Solvent Concentration Compound Temperature Storage Duration of stability References
Glass Water for Injection 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Cyclophosphamide 1 mg/ml
20°C-23°C
4 Hour
Light 57
Level of evidence A+
Glass Water for Injection 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Cytarabine 1 mg/ml
20°C-23°C
4 Hour
Light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Magnesium sulfate 8 mg/ml
20-23°C
4 Hour
Light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Doxorubicin hydrochloride 0,1 mg/ml
20°C-23°C
2 Hour
Protect from light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Cisplatin 0,5 mg/ml
20°C-23°C
4 Hour
Protect from light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Diphenhydramine hydrochloride 0,5 mg/ml
20°C-23°C
4 Hour
Protect from light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Dacarbazine 0,85 mg/ml
20°C-23°C
4 Hour
Protect from light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,12 mg/ml
20°C-23°C
4 Hour
Protect from light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Fluorouracil 1 mg/ml
20°C-23°C
4 Hour
Protect from light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Furosemide 0,2 mg/ml
20°C-23°C
4 Hour
Protect from light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Hydromorphone hydrochloride 0,25 mg/ml
20°C-23°C
4 Hour
Protect from light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Lorazepam 0,05 mg/ml
20°C-23°C
4 Hour
Protect from light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Methotrexate sodium 6,25 mg/ml
20°C-23°C
4 Hour
Protect from light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Morphine sulfate 0,5 mg/ml
20°C-23°C
4 Hour
Protect from light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Carboplatin 0,5 mg/ml
20°C-23°C
4 Hour
Light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Ceftazidime 8,35 mg/ml
20°C-23°C
4 Hour
Light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Cimetidine hydrochloride 1,5 mg/ml
20°C-23°C
4 Hour
Light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Etoposide 0,2 mg/ml
20°C-23°C
4 Hour
Light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Gentamicin sulfate 0,75 mg/ml
20°C-23°C
4 Hour
Light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Ifosfamide 2 mg/ml
20°C-23°C
4 Hour
Light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Chlormethine hydrochloride 0,25 mg/ml
20°C-23°C
4 Hour
Light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Mesna 2 mg/ml
20°C-23°C
4 Hour
Light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Paclitaxel 0,145 mg/ml
20°C-23°C
4 Hour
Light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Streptozocin 4,55 mg/ml
20°C-23°C
4 Hour
Light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Ticarcillin / clavulanic acid 13/0,45 mg/ml
20°C-23°C
4 Hour
Light 57
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Granisetron hydrochloride   
injection   Vincristine sulfate 0,005 mg/ml
20°C-23°C
4 Hour
Light 57
Level of evidence A+
Glass None 0,01 mg/ml
injection   Granisetron hydrochloride   
injection   Rolapitant 1,83 mg/ml
2-8°C
48 Hour
Protect from light 4061
Level of evidence C+
Glass None 0,01 mg/ml
injection   Granisetron hydrochloride   
injection   Rolapitant 1,83 mg/ml
20-25°C
24 Hour
Light 4061
Level of evidence C+
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,056 mg/ml
injection   Granisetron hydrochloride   
injection   Methylprednisolone sodium succinate 2,26 mg/ml
22°C
3 Day
Protect from light 29
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,056 mg/ml
injection   Granisetron hydrochloride   
injection   Dexamethasone sodium phosphate 0.074 >> 0.345 mg/ml
22°C
3 Day
Protect from light 29
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,02 & 0,06 mg/ml
injection   Granisetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,08 & 0,20 mg/ml
23°C
35 Day
Not specified 1633
Level of evidence A
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,010 - 0,040 mg/ml
injection   Granisetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,080 - 0,600 mg/ml
23°C-25°C
14 Day
Protect from light 27
Level of evidence B
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,01 - 0,04 mg/ml
injection   Granisetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,08 - 0,60 mg/ml
4°C
14 Day
Protect from light 27
Level of evidence B
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,02 & 0,06 mg/ml
injection   Granisetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,08 & 0,20 mg/ml
4°C
35 Day
Protect from light 1633
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 0,056 mg/ml
injection   Granisetron hydrochloride   
injection   Hydromorphone hydrochloride 0,5 mg/ml
4°C-22°C
31 Hour
Not specified 6
Level of evidence A+
Polyvinyl chloride Sodium chloride 0,9% 0,056 mg/ml
injection   Granisetron hydrochloride   
injection   Hydromorphone hydrochloride 0,5 mg/ml
4°C-22°C
31 Hour
Not specified 6
Level of evidence A+
Polyolefine Sodium chloride 0,9% 0,06 mg/ml
injection   Granisetron hydrochloride   
injection   Tramadol hydrochloride 10 mg/ml
25°C
14 Day
Not specified 4116
Level of evidence A
Polyolefine Sodium chloride 0,9% 0,06 mg/ml
injection   Granisetron hydrochloride   
injection   Tramadol hydrochloride 10 mg/ml
4°C
14 Day
Not specified 4116
Level of evidence A
Polypropylen Syringe Water for Injection 1 mg/ml
injection   Granisetron hydrochloride   
injection   Paracetamol 10 mg/ml
25°C
4 Hour
Not specified 3571
Level of evidence A+
Polypropylen Syringe NaCl 0,9% or Glucose 5% 0,150 mg/ml
injection   Granisetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,2 & 1 mg/ml
22°C
3 Day
Protect from light 29
Polypropylen Syringe NaCl 0,9% or Glucose 5% 0,15 mg/ml
injection   Granisetron hydrochloride   
injection   Methylprednisolone sodium succinate 6 mg/ml
22°C
3 Day
Protect from light 29
Not specified NaCl 0,9% or Glucose 5% 0,01 mg/ml
injection   Granisetron hydrochloride   
injection   Topotecan 0,028 mg/ml
20°C-23°C
4 Hour
Light 1026
Level of evidence C
  Mentions Légales