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Antiemetic   Palonosetron hydrochloride  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Aloxi Austria, Belgium, Canada, Denmark, Finland, Germany, Great Britain, Greece, Hungary, Iceland, Ireland, Italy, Japan, Luxembourg, Malaysia, Netherlands, Norway, Poland, Portugal, Romania, Spain, Sweden, Switzerland, Turkey, United States of America
Chepatron India
Cinvex Turkey
Factoket Mexico
Lotisa Turkey
Onicit Chile, Colombia, Ecuador, Italy, Peru
Palohalt Chile, Peru
Paloject Turkey
Palonosetron Belgium, Chile, Ecuador, France, Germany, Great Britain, Spain, Switzerland
Palostar India
Palzen India
Vinaltro Mexico
Viqet Mexico
Vonaxi Turkey
Stability of mixtures   injection   Stability of mixtures : Palonosetron hydrochloride     
Container Solvent Concentration Compound Temperature Storage Duration of stability References
Glass Sodium chloride 0,9% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Ampicillin sodium - sulbactam sodium 20/10 mg/ml
25°C
4 Hour
2214
Level of evidence A+
Glass Sodium chloride 0,9% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Cisplatin 0,25 mg/ml
?
4 Hour
Not specified 1950
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Lorazepam 0,25 mg/ml
20°C-25°C
4 Hour
Not specified 1975
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Midazolam hydrochloride 1 mg/ml
20°C-25°C
4 Hour
Not specified 1975
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Topotecan 0,05 mg/ml
20°C-25°C
4 Hour
Not specified 1976
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Irinotecan 0,5 mg/ml
20°C-25°C
4 Hour
Not specified 1976
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Doxorubicin hydrochloride 0,1 mg/ml
23°C
4 Hour
Not specified 1955
Level of evidence A+
Glass Glucose 5% 26 µg/ml
injection   Palonosetron hydrochloride   
injection   Epirubicin hydrochloride 0,26 mg/ml
23°C
4 Hour
Not specified 1955
Level of evidence A+
Glass Glucose 5% 26 µg/ml
injection   Palonosetron hydrochloride   
injection   Fluorouracil 0,08 mg/ml
25°C
4 Hour
Light 2009
Level of evidence A+
Glass Glucose 5% 26 µg/ml
injection   Palonosetron hydrochloride   
injection   Gemcitabine hydrochloride 0.105 mg/ml
25°C
4 Hour
Light 2009
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Dacarbazine 0,05 mg/ml
25°C
4 Hour
Light 2107
Level of evidence A+
Glass Glucose 5% 50 µg/ml
injection   Palonosetron hydrochloride   
injection   Cyclophosphamide 10 mg/ml
25°C
4 Hour
Light 2016
Level of evidence A+
Glass Glucose 5% 50 µg/ml
injection   Palonosetron hydrochloride   
injection   Ifosfamide 20 mg/ml
25°C
4 Hour
Light 2016
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Atropine sulfate 0,19 mg/ml
25°C
4 Hour
Light 2279
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Heparin sodium 50 UI/ml
25°C
4 Hour
Light 2279
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Lidocaine hydrochloride 5,3 mg/ml
25°C
4 Hour
Light 2279
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Potassium chloride 50 mEq/l
25°C
4 Hour
Light 2279
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Famotidine 1 mg/ml
25°C
4 Hour
Light 2279
Level of evidence A+
Glass Glucose 5% 26 µg/ml
injection   Palonosetron hydrochloride   
injection   Suxamethonium chloride 1.05 mg/ml
25°C
4 Hour
Not specified 2227
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Rocuronium bromide 0.5 mg/ml
25°C
4 Hour
Not specified 2227
Level of evidence A+
Glass Glucose 5% 25.4 µg/ml
injection   Palonosetron hydrochloride   
injection   Cisatracurium besylate 0.26 mg/ml
25°C
4 Hour
Not specified 2227
Level of evidence A+
Glass Glucose 5% 26,6 µg/ml
injection   Palonosetron hydrochloride   
injection   Paclitaxel 0,62 mg/ml
25°C
4 Hour
Not specified 1940
Level of evidence A+
Glass Glucose 5% 26,6 µg/ml
injection   Palonosetron hydrochloride   
injection   Docetaxel 0,41 mg/ml
25°C
4 Hour
Not specified 1940
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Promethazine hydrochloride 1 mg/ml
25°C
4 Hour
Not specified 2179
Level of evidence A+
Glass Glucose 5% 25.6 µg/ml
injection   Palonosetron hydrochloride   
injection   Vecuronium bromide 0.5 mg/ml
25°C
4 Hour
Not specified 2227
Level of evidence A+
Glass Glucose 5% 26.7 µg/ml
injection   Palonosetron hydrochloride   
injection   Gentamicin sulfate 5.26 mg/ml
25°C
4 Hour
Not specified 2228
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Metronidazole 2.6 mg/ml
25°C
4 Hour
Not specified 2228
Level of evidence A+
Glass Glucose 5% 27 µg/ml
injection   Palonosetron hydrochloride   
injection   Vancomycin hydrochloride 4.9 mg/ml
25°C
4 Hour
Not specified 2228
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Cefazolin sodium 10 mg/ml
25°C
4 Hour
2214
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Carboplatin 2,5 mg/ml
?
4 Hour
Not specified 1950
Level of evidence A+
Glass Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Oxaliplatin 0,25 mg/ml
?
4 Hour
Not specified 1950
Level of evidence A+
Glass None 2,28 µg/ml
injection   Palonosetron hydrochloride   
injection   Rolapitant 1,65 mg/ml
2-8°C
7 Day
Protect from light 3928
Level of evidence A+
Glass None 2,1 µg/ml
injection   Palonosetron hydrochloride   
injection   Rolapitant 1,6 mg/ml
injection   Dexamethasone sodium phosphate 0,178 mg/ml
2-8°C
48 Hour
Protect from light 4062
Level of evidence C+
Glass None 2,1 µg/ml
injection   Palonosetron hydrochloride   
injection   Rolapitant 1,6 mg/ml
injection   Dexamethasone sodium phosphate 0,093 mg/ml
2-8°C
48 Hour
Protect from light 4062
Level of evidence C+
Glass None 2,28 µg/ml
injection   Palonosetron hydrochloride   
injection   Rolapitant 1,65 mg/ml
20-25°C
2 Day
Protect from light 3928
Level of evidence A+
Glass None 2,1 µg/ml
injection   Palonosetron hydrochloride   
injection   Rolapitant 1,6 mg/ml
injection   Dexamethasone sodium phosphate 0,093 mg/ml
20-25°C
24 Hour
Light 4062
Level of evidence C+
Glass None 2,1 µg/ml
injection   Palonosetron hydrochloride   
injection   Rolapitant 1,6 mg/ml
injection   Dexamethasone sodium phosphate 0,178 mg/ml
20-25°C
24 Hour
Light 4062
Level of evidence C+
Glass None 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Fentanyl citrate 25 µg/ml
25°C
4 Hour
Light 2196
Level of evidence A+
Glass None 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Hydromorphone hydrochloride 0,25 mg/ml
25°C
4 Hour
Light 2196
Level of evidence A+
Glass None 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Morphine sulfate 7,7 mg/ml
25°C
4 Hour
Light 2196
Level of evidence A+
Glass None 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Sufentanil citrate 7 mg/ml
25°C
4 Hour
Light 2196
Level of evidence A+
Glass None 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Sufentanil citrate 0.0062 mg/ml
25°C
4 Hour
Light 2196
Level of evidence A+
Glass None 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Metoclopramide hydrochloride 25 mg/ml
25°C
4 Hour
Not specified 2179
Level of evidence A+
Glass None 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Neostigmine methylsulfate 0,25 mg/ml
25°C
4 Hour
Not specified 2286
Level of evidence A+
Glass None 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Glycopyrronium bromide 0,1 mg/ml
25°C
4 Hour
Not specified 2286
Level of evidence A+
Glass None 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Pethidine hydrochloride 5,5 mg/ml
25°C
4 Hour
2196
Level of evidence A+
Polyvinyl chloride NaCl 0,9% or Glucose 5% 5 µg/ml
injection   Palonosetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,2 & 0,4 mg/ml
25°C
48 Hour
Light 1932
Level of evidence A+
Polyvinyl chloride NaCl 0,9% or Glucose 5% 5 µg/ml
injection   Palonosetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,2 & 0,4 mg/ml
4°C
14 Day
Protect from light 1932
Level of evidence A+
Polypropylene NaCl 0,9% or Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,33 mg/ml
25°C
48 Hour
Light 1932
Level of evidence A+
Polypropylene NaCl 0,9% or Glucose 5% 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,33 mg/ml
4°C
14 Day
Protect from light 1932
Level of evidence A+
Polypropylene None 25 µg/ml
injection   Palonosetron hydrochloride   
injection   Propofol 5 mg/ml
25°C
4 Hour
Light 2312
Level of evidence A
Polyolefine NaCl 0,9% or Glucose 5% 2.5 µg/ml
injection   Palonosetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,2 mg/ml
23-27°C
48 Hour
Light 3981
Level of evidence A+
Polyolefine NaCl 0,9% or Glucose 5% 2.5 µg/ml
injection   Palonosetron hydrochloride   
injection   Dexamethasone sodium phosphate 0,1 mg/ml
23-27°C
48 Hour
Light 3981
Level of evidence A+
Cristal Zenith® None 2,28 µg/ml
injection   Palonosetron hydrochloride   
injection   Rolapitant 1,65 mg/ml
2-8°C
7 Day
Protect from light 3928
Level of evidence A+
Cristal Zenith® None 2,28 µg/ml
injection   Palonosetron hydrochloride   
injection   Rolapitant 1,65 mg/ml
20-25°C
2 Day
Protect from light 3928
Level of evidence A+
  Mentions Légales