Last update :
19/11/2024
Antiemetic   Palonosetron hydrochloride  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Aloxi Austria, Belgium, Canada, Denmark, Finland, Germany, Great Britain, Greece, Hungary, Iceland, Ireland, Italy, Japan, Luxembourg, Malaysia, Netherlands, Norway, Poland, Portugal, Romania, Spain, Sweden, Switzerland, Turkey, United States of America
Chepatron India
Cinvex Turkey
Factoket Mexico
Lotisa Turkey
Onicit Chile, Colombia, Ecuador, Italy, Peru
Palohalt Chile, Peru
Paloject Turkey
Palonosetron Belgium, Chile, Ecuador, France, Germany, Great Britain, Spain, Switzerland
Palostar India
Palzen India
Vinaltro Mexico
Viqet Mexico
Vonaxi Turkey
Compatibility   injection   Compatibility : Palonosetron hydrochloride              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Ampicillin sodium - sulbactam sodium 20/10 mg/ml
Sodium chloride 0,9% 2214
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Atropine sulfate 0.4 mg/ml
Glucose 5% 2279
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Carboplatin 5 mg/ml
Glucose 5% 1950
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Cefazolin sodium 20 mg/ml
Glucose 5% 2214
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Cisatracurium besylate 0,5 mg/ml
Glucose 5% 2227
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Cisplatin 0,5 mg/ml
Sodium chloride 0,9% 1950
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Cyclophosphamide 10 mg/ml
Glucose 5% 2016
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Dacarbazine 4 mg/ml
Glucose 5% 2107
Compatible
injection Palonosetron hydrochloride 2.5 µg/ml
injection Dexamethasone sodium phosphate 0.1 & 0.2 mg/ml
NaCl 0,9% or Glucose 5% 3981
Compatible
injection Palonosetron hydrochloride 5 & 25 µg/ml
injection Dexamethasone sodium phosphate 0,2 >> 0,4 mg/ml
NaCl 0,9% or Glucose 5% 1932
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Docetaxel 0,8 mg/ml
Glucose 5% 1940
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Doxorubicin hydrochloride 1 mg/ml
Glucose 5% 1955
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Epirubicin hydrochloride 0,5 mg/ml
Glucose 5% 1955
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Famotidine 2 mg/ml
Glucose 5% 2279
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Fentanyl citrate 50 µg/ml
Glucose 5% 2196
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Fluorouracil 16 mg/ml
Glucose 5% 2009
Chemical instability Incompatible
injection Palonosetron hydrochloride 2 µg/ml
injection Fosaprepitant dimeglumine 1 mg/ml
3459
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Gemcitabine hydrochloride 10 mg/ml
Glucose 5% 2009
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Gentamicin sulfate 5 mg/ml
Glucose 5% 2228
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Glycopyrronium bromide 0,2 mg/ml
None 2286
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Heparin sodium 100 UI/ml
Glucose 5% 2279
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Hetastarch 60 mg/ml
Ringer’s lactate solution 2281
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Hydromorphone hydrochloride 0.5 mg/ml
Glucose 5% 2196
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Ifosfamide 20 mg/ml
Glucose 5% 2016
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Irinotecan 1 mg/ml
Glucose 5% 1976
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Lidocaine hydrochloride 10 mg/ml
Glucose 5% 2279
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Lorazepam 0,5 mg/ml
Glucose 5% 1975
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Mannitol 150 mg/ml
None 2281
Precipitation after 4 hours Incompatible
injection Palonosetron hydrochloride 50 µg/ml
injection Methylprednisolone sodium succinate 5 mg/ml
Glucose 5% 2107
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Metoclopramide hydrochloride 50 mg/ml
None 2179
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Metronidazole 5 mg/ml
Glucose 5% 2228
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Midazolam hydrochloride 2 mg/ml
Glucose 5% 1975
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Morphine sulfate 15 mg/ml
Glucose 5% 2196
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Neostigmine methylsulfate 0,5 mg/ml
None 2286
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Oxaliplatin 0,5 mg/ml
Glucose 5% 1950
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Paclitaxel 1,2 mg/ml
Glucose 5% 1940
Compatible
injection Palonosetron hydrochloride
injection Paclitaxel albumin 5 mg/ml
Sodium chloride 0,9% 4310
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Pethidine hydrochloride 10 mg/ml
Glucose 5% 2196
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Potassium chloride 100 mEq/l
Glucose 5% 2279
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Promethazine hydrochloride 2 mg/ml
None 2179
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Propofol 10 mg/ml
None 2312
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Rocuronium bromide 1 mg/ml
Glucose 5% 2227
Compatible
injection Palonosetron hydrochloride 2.5 µg/ml
injection Rolapitant 1.65 mg/ml
None 3928
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Sufentanil citrate 0.0125 mg/ml
Glucose 5% 2196
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Suxamethonium chloride 2 mg/ml
Glucose 5% 2227
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Topotecan 0,1 mg/ml
Glucose 5% 1976
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Vancomycin hydrochloride 5 mg/ml
Glucose 5% 2228
Compatible
injection Palonosetron hydrochloride 50 µg/ml
injection Vecuronium bromide 1 mg/ml
Glucose 5% 2227

  Mentions Légales