Last update :
19/11/2024
Anticancer drug   Doxorubicin hydrochloride liposome peg  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
Liposome   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Caelyx Austria, Belgium, Brazil, Canada, Chile, Colombia, Denmark, Ecuador, Finland, France, Germany, Great Britain, Greece, Hungary, Iceland, India, Iran, Ireland, Italy, Japan, Luxembourg, Malaysia, Netherlands, New Zealand, Norway, Peru, Poland, Portugal, Romania, Spain, Sweden, Thailand, United Arab Emirates, Venezuela
Doxil United States of America
Compatibility   injection   Compatibility : Doxorubicin hydrochloride liposome peg              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Aciclovir sodium 7 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Allopurinol sodium 3 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Aminophylline 2.5 mg/ml
Glucose 5% 251
Immediate precipitation Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Amphotericin B 0.6 mg/ml
Glucose 5% 251
Immediate precipitation Incompatible
injection Doxorubicin hydrochloride liposome peg 2 mg/ml
injection Amphotericin B cholesteryl sulfate complex 0.83 mg/ml
Glucose 5% 921
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Ampicillin sodium 20 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Aztreonam 40 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Bleomycin sulfate 1 mg/ml
Glucose 5% 251
Loss of turbidity Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Buprenorphine hydrochloride 0.04 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Butorphanol tartrate 0.04 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Calcium gluconate 40 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Carboplatin 5 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Cefazolin sodium 20 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Cefepime dihydrochloride 20 mg/ml
Glucose 5% 251
Loss of turbidity Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Cefoperazone sodium 40 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Cefoxitin sodium 20 mg/ml
Glucose 5% 251
Loss of turbidity Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Ceftazidime 40 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Ceftizoxime sodium 20 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Ceftriaxone disodium 20 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Chlorpromazine hydrochloride 2 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Cimetidine hydrochloride 12 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Ciprofloxacin lactate 1 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Cisplatin 1 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Clindamycin phosphate 10 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Co-trimoxazole 0.8/4 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Cyclophosphamide 10 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Cytarabine 50 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Dacarbazine 4 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Diphenhydramine hydrochloride 2 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Dobutamine hydrochloride 4 mg/ml
Glucose 5% 251
Loss of turbidity Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Docetaxel 2 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Dopamine hydrochloride 3.2 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Droperidol 0.4 mg/ml
Glucose 5% 251
Loss of turbidity Incompatible
injection Doxorubicin hydrochloride liposome peg
NaHCO3 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Enalaprilate 0.1 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Etoposide 0.4 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Famotidine 2 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Fluconazole 2 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Fluorouracil 16 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Folinate calcium 2 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Furosemide 3 mg/ml
Glucose 5% 251
Loss of turbidity Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Gallium nitrate 0.4 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Ganciclovir sodium 20 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Gentamicin sulfate 5 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Granisetron hydrochloride 0.05 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Haloperidol lactate 0.2 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Heparin sodium 1000 UI/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Hydrocortisone sodium succinate 1 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Hydromorphone hydrochloride 0.5 mg/ml
Glucose 5% 251
Immediate precipitation Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Hydroxyzine dihydrochloride 2 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Ifosfamide 25 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Lorazepam 0.1 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Magnesium sulfate 100 mg/ml
Glucose 5% 251
Loss of turbidity Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Mannitol 150 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Mesna 10 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Methotrexate sodium 15 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Methylprednisolone sodium succinate 5 mg/ml
Glucose 5% 251
Immediate turbidity Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Metoclopramide hydrochloride 5 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Metronidazole 5 mg/ml
Glucose 5% 251
Loss of turbidity Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Mitoxantrone dihydrochloride 0.5 mg/ml
Glucose 5% 251
Loss of turbidity Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Morphine sulfate 1 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Netilmicin sulfate 5 mg/ml
Glucose 5% 251
Immediate turbidity Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Ofloxacin 4 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Ondansetron hydrochloride 1 mg/ml
Glucose 5% 251
Loss of turbidity Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Paclitaxel 0.6 mg/ml
Glucose 5% 251
Loss of turbidity Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Pethidine hydrochloride 4 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Piperacillin sodium 40 mg/ml
Glucose 5% 251
Loss of turbidity Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Piperacillin sodium / tazobactam 40/5 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Potassium chloride 100 mEq/l
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Prochlorperazine edysilate 0.5 mg/ml
Glucose 5% 251
Immediate turbidity Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Promethazine hydrochloride 2 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Ranitidine hydrochloride 2 mg/ml
Glucose 5% 251
Loss of turbidity Incompatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Sodium bicarbonate 84 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Ticarcillin / clavulanic acid 31 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Tobramycin sulfate 5 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Vancomycin hydrochloride 10 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Vinblastine sulfate 0.12 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Vincristine sulfate 0.05 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Vinorelbine tartrate 1 mg/ml
Glucose 5% 251
Compatible
injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
injection Zidovudine 4 mg/ml
Glucose 5% 251

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