Last update :
29/10/2024
Antibiotic   Flucloxacillin sodium  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Astaph Morocco
Betabiotic Italy
DBL flucloxacillin sodium Australia
Flix Turkey
Floxam Morocco
Floxapen Austria, Belgium, Italy, Morocco, Netherlands, Poland, Portugal, Saudi Arabia, Switzerland, United States of America
Flucloxacillin Germany, Great Britain, Italy
Flucloxacilline Netherlands
Flucloxin New Zealand
Ladropen United States of America
Stafoxil Netherlands
Staphylex Germany
References   injection   References : Flucloxacillin sodium  
Type Publication
186 Journal Swart EL, Mooren RAG, Van Loenen AC.
Compatibility of midazolam hydrochloride and lorazepam with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1995 ; 52: 2020-2022.
889 Journal Janknegt R, Stratermans T, Cilissen J, Lohman JJHM, Hooymans PM.
Ofloxacin intravenous. Compatibility with other antibacterial agents.
Pharm Weekbl [Sci] 1991 ; 13: 207-209.
939 Journal Gilbar PJ, Groves CF.
Visual compatibility of total parenteral nutrition solution (Synthamin 17 Premix*) with selected drugs during simulated Y-site injection.
Aust J Hosp Pharm 1994 ; 24: 167-170.
1232 Journal Beatson C, Taylor A.
A physical compatibility study of furosemide & flucloxacillin injections.
Br J Pharm Pract 1987 ; 9: 223-226, 236.
1300 Journal Ahmed ST, Parkinson R.
The stability of drugs in pre-filled syringes: flucloxacillin, ampicillin, cefuroxime, cefotaxime and ceftazidime.
Hosp Pharm Pract 1992 ; 2: 285-289.
1349 Journal Sanburg AL, LyndonRC, Sunderland B.
Effects of freezing, long term storage and microwave thawing on the stability of three antibiotics reconstituted in minibags.
Aust J Hosp Pharm 1987 ; 17: 31-34.
1357 Journal Janknegt R, Schrouff GGM, Hooymans PM, Hermens WJHH, Lohman JJHM.
Quinolones and penicillins incompatibility.
Ann Pharmacotherapy 1989 ; 23: 91-92.
1494 Journal McLaughlin JP, Simpson C.
When is flucloxacillin stable ?
Hosp Pharm Pract 1993 ; 3: 553-556.
1845 Journal Müller HJ, Haker I.
The stability of amoxicillin, ampicillin, benzylpenicillin, flucloxacillin, mezlocillin and piperacillin in isotonic saline solutions when stored in an innovative infusion container (Freeflex container).
EJHP 2003 ; 6: 106-111.
2231 Journal de Jongh R, Hens R, Basma V, mouton JW, Tulkens PM, Carryn S.
Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection.
J Antimicrob Chemother 2008 ; 61, 2: 382-388.
3091 Journal Thalhammer F, Maier-Salamon A, Jäger W.
Prüfung von Stabilität und Kompatibilität von Flucloxacillin (Floxapen®) und Ceftazidim (Fortum®) in zwei Infusionslösungen:Relevanz für die klinische Praxis.
Wien Med Wochenschr 2005 ; 155, 13-14: 337-343.
3189 Journal Tho T-P, Ching MS, Elis AG, Williams L, Garrett MK.
Stability of intravenous flucloxacillin solutions used for hospital-in-the-home.
J Pharm Pract and Res 2010 ; 40, 2: 101-105.
3385 Journal Raverdi V, Ampe E, Hecq JD, Tulkens PM.
Stability and compatibility of vancomycin for administration by continuous infusion.
J Antimicrob Chemother 2013 ; 68: 1179-1182.
3522 Manufacturer Flucloxacillin - Summary of Product Characteristics.
Actavis 2013
3529 Manufacturer Ciprofloxacin – Summary of Product Characteristics
Hospira 2013
3585 Manufacturer Benzylpenicillin sodium - Summary of Product Characteristics
Genus Pharmaceuticals 2008
3643 Manufacturer Gentamicin sulphate (Cidomycin®) - Summary of Product Characteristics
Sanofi 2015
3674 Manufacturer Erythromycin lactobionate - Summary of Product Characteristics
PanPharma 2016
4218 Journal Allwood M.C,Stonkute D, Wallace A, Wilkinson A-S, Hills T, Jamieson C,
Assessment of the stability of citrate-buffered flucloxacillin for injection when stored in two commercially available ambulatory elastomeric devices: INfusor LV (Baxter) and Accufuser (Woo Young Medical): a study compliant with the NHS Yellow Cover Document (YCD) requirements.
EJHP 2020 ; 27, 2: 90-94.
4538 Journal Campbell A, Petrovski M, Senarathna G, Mukadam ,Strunk T, Batty K.
Compatibility of pentoxifylline and parenteral medications.
Archives of Disease in Childhood 2020 ; 105: 395-397.
4590 Journal Smith E.K, McWhinney MPhil B.C.
Stability of buffered benzylpenicillin and flucloxacillin for a paediatric outpatient parenteral antibiotic therapy service.
J Pediatr Pharmacol Ther 2021 ; 51: 231-237.
4837 Journal De Silva, D.T.N Petrovski M, Strunk T, Mukadam N, Page‑Sharp N, Moore B.R, Batty K.T.
Physicochemical compatibility of caffeine citrate and caffeine base injections with parenteral medications used in neonatal intensive care settings.
Eur J Clin Pharmacol 2024 ; 80:1079–1087.

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