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Local anesthetic   Bupivacaine hydrochloride  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Bicain Finland
Bucain Austria, Germany
Bucaine Saudi Arabia
Bupi Alleman Germany
Bupinest Colombia, Ecuador
Bupirop Ecuador
Bupisen Italy
Bupivacain Germany
Bupivacaina Chile, Spain
Bupivacaine Australia, Great Britain, Ireland, Morocco, Tunisia
Bupivan Chile, Germany
Buvacaina Mexico
Buvasin Turkey
Carbostesin Austria, Germany
Dolanaest Austria, Germany
Duracaine Argentina
Inibsacain Spain
Marcain Australia, Denmark, Egypt, Malaysia, New Zealand
Marcaine Belgium
Sensorcaine Canada
Sinebupiv Ecuador
Stability of mixtures   injection   Stability of mixtures : Bupivacaine hydrochloride     
Container Solvent Concentration Compound Temperature Storage Duration of stability References
Glass Sodium chloride 0,9% 7,5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Morphine hydrochloride 0,2 mg/ml
20°C-25°C
540 Day
Light 1885
Level of evidence A
Glass None 25 mg/ml
injection   Bupivacaine hydrochloride   
injection   Morphine sulfate 50 mg/ml
injection   Clonidine hydrochloride 2 mg/ml
37°C
90 Day
Protect from light 1948
Level of evidence A
Glass None 25 mg/ml
injection   Bupivacaine hydrochloride   
injection   Morphine sulfate 50 mg/ml
injection   Clonidine hydrochloride 2 mg/ml
4°C
90 Day
Protect from light 1948
Level of evidence A
Polyvinyl chloride Not specified 3 mg/ml
injection   Bupivacaine hydrochloride   
injection   Morphine hydrochloride 6,66 mg/ml
injection   Clonidine hydrochloride 0,03 mg/ml
25°C
90 Day
Not specified 346
Level of evidence D
Polyvinyl chloride Not specified 3 mg/ml
injection   Bupivacaine hydrochloride   
injection   Sufentanil citrate 0,02 mg/ml
26°C
10 Day
Not specified 1491
Level of evidence D
Polyvinyl chloride Not specified 3 mg/ml
injection   Bupivacaine hydrochloride   
injection   Sufentanil citrate 0,02 mg/ml
37°C
10 Day
Not specified 1491
Level of evidence D
Polyvinyl chloride Not specified 3 mg/ml
injection   Bupivacaine hydrochloride   
injection   Sufentanil citrate 0,02 mg/ml
4°C
10 Day
Protect from light 1491
Level of evidence D
Polyvinyl chloride Sodium chloride 0,9% 1,5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Diamorphine hydrochloride 0,02 mg/ml
-18C
180 Day
Protect from light 512
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 1,250 mg/ml
injection   Bupivacaine hydrochloride   
injection   Fentanyl citrate 20 µg/ml
23°C
30 Day
With or without light 60
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 0,62 & 1,2 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0,02 & 0,1 mg/ml
23°C-25°C
72 Hour
Light 306
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 0,62 & 1,25 mg/ml
injection   Bupivacaine hydrochloride   
injection   Morphine sulfate 0,1 & 0,5 mg/ml
23°C-25°C
72 Hour
Light 220
Polyvinyl chloride Sodium chloride 0,9% 1,25 mg/ml
injection   Bupivacaine hydrochloride   
injection   Diamorphine hydrochloride 0,125 mg/ml
25°C
28 Day
Light 1292
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 1,5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Diamorphine hydrochloride 0,02 mg/ml
25°C
24 Hour
Light 512
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 0.5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0.0015 mg/ml
25°C
30 Day
Not specified 4746
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 0.5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0.03 mg/ml
25°C
30 Day
Not specified 4746
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 2.5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0.03 mg/ml
25°C
30 Day
Not specified 4746
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 2.5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0.0015 mg/ml
25°C
30 Day
Not specified 4746
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 0,04 mg/ml
injection   Bupivacaine hydrochloride   
injection   Sufentanil citrate 0,012 mg/ml
25°C
43 Day
Not specified 1909
Polyvinyl chloride Sodium chloride 0,9% 0,59 & 1,25 mg/ml
injection   Bupivacaine hydrochloride   
injection   Fentanyl citrate 2 µg/ml
25°C-30°C
32 Day
Light 1723
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 0,43 mg/ml
injection   Bupivacaine hydrochloride   
injection   Epinephrine hydrochloride 0,0006 µg/ml
injection   Fentanyl citrate 1,25 µg/ml
30°C
48 Hour
Protect from light 217
Level of evidence C
Polyvinyl chloride Sodium chloride 0,9% 2 mg/ml
injection   Bupivacaine hydrochloride   
injection   Sufentanil citrate 0,005 mg/ml
32°C
3 Day
Not specified 510
Polyvinyl chloride Sodium chloride 0,9% 0,43 mg/ml
injection   Bupivacaine hydrochloride   
injection   Epinephrine hydrochloride 0,0006 µg/ml
injection   Fentanyl citrate 1,25 µg/ml
3°C
20 Day
Protect from light 217
Level of evidence C
Polyvinyl chloride Sodium chloride 0,9% 1,250 mg/ml
injection   Bupivacaine hydrochloride   
injection   Fentanyl citrate 20 µg/ml
3°C
30 Day
With or without light 60
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 0,59 & 1,25 mg/ml
injection   Bupivacaine hydrochloride   
injection   Fentanyl citrate 2 µg/ml
4-8°C
32 Day
Protect from light 1723
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 2 mg/ml
injection   Bupivacaine hydrochloride   
injection   Sufentanil citrate 0,005 mg/ml
4°C
30 Day
Protect from light 510
Polyvinyl chloride Sodium chloride 0,9% 0.5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0.0015 mg/ml
4°C
30 Day
Not specified 4746
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 0.5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0.03 mg/ml
4°C
30 Day
Not specified 4746
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 2.5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0.03 mg/ml
4°C
30 Day
Not specified 4746
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 2.5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0.0015 mg/ml
4°C
30 Day
Not specified 4746
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 0,04 mg/ml
injection   Bupivacaine hydrochloride   
injection   Sufentanil citrate 0,012 mg/ml
4°C
43 Day
Not specified 1909
Polyvinyl chloride Sodium chloride 0,9% 1,5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Diamorphine hydrochloride 0,02 mg/ml
7°C
14 Day
Protect from light 512
Level of evidence A
Polyvinyl chloride None 2,5 et 5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Diamorphine hydrochloride 0,5 >> 10 mg/ml
25°C
8 Day
Protect from light 2307
Level of evidence B
Polyvinyl chloride Not specified 1 mg/ml
injection   Bupivacaine hydrochloride   
injection   Epinephrine hydrochloride 2 µg/ml
injection   Fentanyl citrate 2 µg/ml
18-22°C
184 Day
Protect from light 2306
Level of evidence B
Polyvinyl chloride Not specified 1 mg/ml
injection   Bupivacaine hydrochloride   
injection   Fentanyl citrate 2 µg/ml
18-22°C
184 Day
Protect from light 2306
Level of evidence B
Polyvinyl chloride Not specified 1 mg/ml
injection   Bupivacaine hydrochloride   
injection   Fentanyl citrate 2 µg/ml
injection   Epinephrine hydrochloride 2 µg/ml
4°C
184 Day
Protect from light 2306
Level of evidence B
Polyvinyl chloride Not specified 1 mg/ml
injection   Bupivacaine hydrochloride   
injection   Fentanyl citrate 2 µg/ml
4°C
184 Day
Protect from light 2306
Level of evidence B
Polypropylene Water for Injection 25 mg/ml
injection   Bupivacaine hydrochloride   
injection   Morphine sulfate 50 mg/ml
23°C
60 Day
Light 1707
Level of evidence A+
Polypropylene Water for Injection 25 mg/ml
injection   Bupivacaine hydrochloride   
injection   Morphine sulfate 50 mg/ml
37°C
48 Hour
Protect from light 1707
Level of evidence A+
Polypropylene Water for Injection 25 mg/ml
injection   Bupivacaine hydrochloride   
injection   Morphine sulfate 50 mg/ml
4°C
60 Day
Protect from light 1707
Level of evidence A+
Polypropylene Sodium chloride 0,9% 0,00125 mg/ml
injection   Bupivacaine hydrochloride   
injection   Sufentanil citrate 0,0005 mg/ml
2-8°C
28 Day
Protect from light 2319
Level of evidence B
Polypropylene Sodium chloride 0,9% 2,5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Morphine sulfate 5 mg/ml
23°C
60 Day
Light 1707
Level of evidence A+
Polypropylene Sodium chloride 0,9% 2,5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Morphine sulfate 5 mg/ml
37°C
48 Hour
Protect from light 1707
Level of evidence A+
Polypropylene Sodium chloride 0,9% 2,5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Morphine sulfate 5 mg/ml
4°C
60 Day
Protect from light 1707
Level of evidence A+
Polypropylene None 1 mg/ml
injection   Bupivacaine hydrochloride   
injection   Epinephrine hydrochloride 2 µg/ml
injection   Fentanyl citrate 2 µg/ml
22°C
180 Day
Light 1875
Level of evidence B
Polypropylene None 1 mg/ml
injection   Bupivacaine hydrochloride   
injection   Epinephrine hydrochloride 2 µg/ml
injection   Fentanyl citrate 2 µg/ml
4°C
180 Day
Protect from light 1875
Level of evidence B
Polyolefine Sodium chloride 0,9% 1,2 mg/ml
injection   Bupivacaine hydrochloride   
injection   Tramadol hydrochloride 4 mg/ml
25°C
15 Day
With or without light 3296
Level of evidence C
Polyolefine Sodium chloride 0,9% 0.5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0.0015 mg/ml
25°C
30 Day
Not specified 4746
Level of evidence A
Polyolefine Sodium chloride 0,9% 0.5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0.03 mg/ml
25°C
30 Day
Not specified 4746
Level of evidence A
Polyolefine Sodium chloride 0,9% 2.5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0.03 mg/ml
25°C
30 Day
Not specified 4746
Level of evidence A
Polyolefine Sodium chloride 0,9% 2.5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0.0015 mg/ml
25°C
30 Day
Not specified 4746
Level of evidence A
Polyolefine Sodium chloride 0,9% 1,2 mg/ml
injection   Bupivacaine hydrochloride   
injection   Tramadol hydrochloride 4 mg/ml
4°C
15 Day
Protect from light 3296
Level of evidence C
Polyolefine Sodium chloride 0,9% 0.5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0.0015 mg/ml
4°C
30 Day
Not specified 4746
Level of evidence A
Polyolefine Sodium chloride 0,9% 0.5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0.03 mg/ml
4°C
30 Day
Not specified 4746
Level of evidence A
Polyolefine Sodium chloride 0,9% 2.5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0.03 mg/ml
4°C
30 Day
Not specified 4746
Level of evidence A
Polyolefine Sodium chloride 0,9% 2.5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0.0015 mg/ml
4°C
30 Day
Not specified 4746
Level of evidence A
Polypropylen Syringe Sodium chloride 0,9% 2,5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0,02 & 0,04 mg/ml
22°C
91 Day
Light 1931
Level of evidence A
Polypropylen Syringe Sodium chloride 0,9% 2,5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 0,02 & 0,04 mg/ml
6°C
91 Day
Protect from light 1931
Level of evidence A
Polypropylen Syringe Glucose 8% 4 mg/ml
injection   Bupivacaine hydrochloride   
injection   Diamorphine hydrochloride 0,1 mg/ml
7°C
26 Day
Not specified 2308
Level of evidence B
Not specified Sodium chloride 0,9% 4 mg/ml
injection   Bupivacaine hydrochloride   
injection   Morphine tartrate 1 mg/ml
injection   Midazolam hydrochloride 0,5 mg/ml
22°C
28 Day
Protect from light 2083
Level of evidence B
Not specified Sodium chloride 0,9% 1 mg/ml
injection   Bupivacaine hydrochloride   
injection   Morphine sulfate 0,05 mg/ml
23°C
28 Day
Light 1276
Level of evidence D
Not specified Sodium chloride 0,9% 24 mg/ml
injection   Bupivacaine hydrochloride   
injection   Morphine sulfate 50 mg/ml
injection   Clonidine hydrochloride 2 mg/ml
37°C
90 Day
Protect from light 2305
Not specified Sodium chloride 0,9% 24 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 50 mg/ml
injection   Clonidine hydrochloride 2 mg/ml
37°C
90 Day
Protect from light 2305
Not specified Sodium chloride 0,9% 1 mg/ml
injection   Bupivacaine hydrochloride   
injection   Morphine sulfate 0,05 mg/ml
4°C
28 Day
Protect from light 1276
Level of evidence D
Not specified None 5 mg/ml
injection   Bupivacaine hydrochloride   
injection   Ziconotide acetate 25 µg/ml
37°C
22 Day
Protect from light 2252
Level of evidence B
Not specified None 10 mg/ml
injection   Bupivacaine hydrochloride   
injection   Hydromorphone hydrochloride 15 mg/ml
37°C
90 Day
Protect from light 4200
Level of evidence A
  Mentions Légales