Last update :
19/11/2024
Thrombolytic   Alteplase  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Actilyse Argentina, Australia, Austria, Belgium, Brazil, Chile, Colombia, Denmark, Finland, France, Germany, Great Britain, Greece, Hungary, Iceland, Ireland, Italy, Luxembourg, Malaysia, Mexico, New Zealand, Norway, Peru, Poland, Portugal, Romania, Saudi Arabia, Slovenia, Spain, Sweden, Switzerland, Tunisia, Turkey, United Arab Emirates, Venezuela
Activase Canada, United States of America
Cathflo Activase Canada, United States of America
Compatibility   injection   Compatibility : Alteplase              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Immediate precipitation Incompatible
injection Alteplase
injection Bivalirudin
3539
Immediate turbidity Incompatible
injection Alteplase
Glucose 5% 3616
Immediate precipitation Incompatible
injection Alteplase 1 mg/ml
injection Bivalirudin 5 mg/ml
Glucose 5% 1713
Immediate precipitation Incompatible
injection Alteplase 0.5 mg/ml
injection Dobutamine hydrochloride 5 mg/ml
Water for Injection 240
Immediate precipitation Incompatible
injection Alteplase 1 mg/ml
injection Dobutamine hydrochloride 2 mg/ml
Water for Injection 92
Chemical instability Incompatible
injection Alteplase 0.5 mg/ml
injection Dopamine hydrochloride 0.8 mg/ml
Water for Injection 240
Precipitation after 4 hours Incompatible
injection Alteplase 1 mg/ml
injection Dopamine hydrochloride 8 mg/ml
Water for Injection 92
Precipitation after 24 hours Incompatible
injection Alteplase 1 mg/ml
injection Heparin sodium 100 UI/ml
Water for Injection 92
Immediate precipitation Incompatible
injection Alteplase 0.5 mg/ml
injection Heparin sodium 40 UI/ml
Water for Injection 240
Unspecified incompatibility Incompatible
injection Alteplase
injection Heparin sodium
3540
Unspecified incompatibility Incompatible
injection Alteplase
injection Heparin sodium
3616
Compatible
injection Alteplase 0.5 mg/ml
injection Lidocaine hydrochloride 4 mg/ml
Water for Injection 240
Compatible
injection Alteplase 1 mg/ml
injection Lidocaine hydrochloride 8 mg/ml
Water for Injection 92
Compatible
injection Alteplase 0.5 mg/ml
injection Metoprolol tartrate 0.5 mg/ml
Water for Injection 240
Chemical instability Incompatible
injection Alteplase 0.5 mg/ml
injection Morphine sulfate 1 mg/ml
Water for Injection 240
Precipitation after 12 hours Incompatible
injection Alteplase 1 mg/ml
injection Nitroglycerin 0.2 mg/ml
Water for Injection 92
Compatible
injection Alteplase 0.5 mg/ml
injection Nitroglycerin 0.4 mg/ml
Water for Injection 240
Compatible
injection Alteplase 0.5 mg/ml
injection Propranolol hydrochloride 0.5 mg/ml
Water for Injection 240

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