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Thrombolytic   Alteplase  
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Actilyse Argentina, Australia, Austria, Belgium, Brazil, Chile, Colombia, Denmark, Finland, France, Germany, Great Britain, Greece, Hungary, Iceland, Ireland, Italy, Luxembourg, Malaysia, Mexico, New Zealand, Norway, Peru, Poland, Portugal, Romania, Saudi Arabia, Spain, Sweden, Switzerland, Tunisia, Turkey, United Arab Emirates, Venezuela
Activase Canada, United States of America
Cathflo Activase Canada, United States of America
References   Injection   References : Alteplase  
Type Publication
92 Journal Lee CY, Mauro VF, Alexander KS.
Visual and spectrophotometric determination of compatibility of alteplase and streptokinase with other injectable drugs.
Am J Hosp Pharm 1990 ; 47: 606-608.
240 Journal Lam XM, Ward CA, de C du M?e CPR.
Stability and activity of alteplase with injectable drugs commonly used in cardiac therapy.
Am J Health-Syst Pharm 1995 ; 52: 1904-1909.
1713 Journal Trissel LA, Saenz CA.
Compatibility screening of bivalirudin during simulated Y-site administration with other drugs.
Int J Pharm Compound 2002 ; 6: 311-315.
3539 Manufacturer Bivalirudin (Angiox®) - Summary of Product Characteristics.
The Medecines Company 2013
3540 Manufacturer Heparin sodium - Summary of Product Characteristics.
Wockhardt 2010
3616 Manufacturer Altéplase (Actilyse®) - Résumé des caractéristiques du produit
Boehringer Ingelheim 2012
3862 Journal Cutshall B.T, Gorman G.S, Freeman M.K ,. Kyle J.A.
Enzymatic Stability of Alteplase Solution for Injection: Effect of Various Methods of Thawing Frozen Solutions.
Hosp Pharm 2016 ; 51, 3: 246-251.

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