Monographie - Alteplase - Stabilis 4.0

Last update :
03/05/2024

Thrombolytic

Alteplase

Injection

Stability in solutions

Stability of mixtures

Factors which affect stability

Compatibility

Route of administration

References

Pdf

Tradename

Tradename

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Actilyse	Argentina, Australia, Austria, Belgium, Brazil, Chile, Colombia, Denmark, Finland, France, Germany, Great Britain, Greece, Hungary, Iceland, Ireland, Italy, Luxembourg, Malaysia, Mexico, New Zealand, Norway, Peru, Poland, Portugal, Romania, Saudi Arabia, Slovenia, Spain, Sweden, Switzerland, Tunisia, Turkey, United Arab Emirates, Venezuela
Activase	Canada, United States of America
Cathflo Activase	Canada, United States of America

References

Injection

References : Alteplase

	Type	Publication
92	Journal	Lee CY, Mauro VF, Alexander KS. Visual and spectrophotometric determination of compatibility of alteplase and streptokinase with other injectable drugs. Am J Hosp Pharm 1990 ; 47: 606-608.
240	Journal	Lam XM, Ward CA, de C du M?e CPR. Stability and activity of alteplase with injectable drugs commonly used in cardiac therapy. Am J Health-Syst Pharm 1995 ; 52: 1904-1909.
1713	Journal	Trissel LA, Saenz CA. Compatibility screening of bivalirudin during simulated Y-site administration with other drugs. Int J Pharm Compound 2002 ; 6: 311-315.
3539	Manufacturer	Bivalirudin (Angiox®) - Summary of Product Characteristics. The Medecines Company 2013
3540	Manufacturer	Heparin sodium - Summary of Product Characteristics. Wockhardt 2010
3616	Manufacturer	Altéplase (Actilyse®) - Résumé des caractéristiques du produit Boehringer Ingelheim 2012
3862	Journal	Cutshall B.T, Gorman G.S, Freeman M.K ,. Kyle J.A. Enzymatic Stability of Alteplase Solution for Injection: Effect of Various Methods of Thawing Frozen Solutions. Hosp Pharm 2016 ; 51, 3: 246-251.

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