Last update :
19/11/2024
References   References 939  
Type : Journal

Research teams : Toowoomba - Toowoomba Base Hospital, Pharmacy Department
Authors : Gilbar PJ, Groves CF.
Title : Visual compatibility of total parenteral nutrition solution (Synthamin 17 Premix*) with selected drugs during simulated Y-site injection.
Reference : Aust J Hosp Pharm ; 24: 167-170. 1994

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionAminophylline Various
Compatible 1 mg/ml + Parenteral nutrition (binary mixture)
injectionAmoxicillin sodium Antibiotic
Compatible 50 mg/ml + Parenteral nutrition (binary mixture)
injectionAscorbic acid Vitamin
Compatible 20 mg/ml + Parenteral nutrition (binary mixture)
injectionAtracurium besylate Curarimimetic
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
injectionCalcium gluconate Electrolyte
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
injectionCefalotin sodium Antibiotic
Compatible 100 mg/ml + Parenteral nutrition (binary mixture)
injectionCefotaxime sodium Antibiotic
Compatible 200 mg/ml + Parenteral nutrition (binary mixture)
injectionCefoxitin sodium Antibiotic
Compatible 200 mg/ml + Parenteral nutrition (binary mixture)
injectionCeftazidime Antibiotic
Compatible 200 mg/ml + Parenteral nutrition (binary mixture)
injectionCeftriaxone disodium Antibiotic
Compatible 100 mg/ml + Parenteral nutrition (binary mixture)
injectionCimetidine hydrochloride Antihistamine (H2)
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
injectionClonazepam Antiepileptic
Compatible 1 mg/ml + Parenteral nutrition (binary mixture)
injectionDiazepam Anxiolytic
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
injectionDobutamine hydrochloride Cardiotonic
Compatible 50 mg/ml + Parenteral nutrition (binary mixture)
injectionDopamine hydrochloride Cardiotonic
Compatible 1.6 mg/ml + Parenteral nutrition (binary mixture)
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 200 µg/ml + Parenteral nutrition (binary mixture)
injectionErythromycin lactobionate Antibiotic
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
injectionFlucloxacillin sodium Antibiotic
Compatible 50 mg/ml + Parenteral nutrition (binary mixture)
injectionFurosemide Diuretic
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
injectionGentamicin sulfate Antibiotic
Compatible 1 mg/ml + Parenteral nutrition (binary mixture)
injectionHaloperidol lactate Neuroleptic
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
injectionHeparin sodium Anticoagulant
Compatible 500 UI/ml + Parenteral nutrition (binary mixture)
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 50 mg/ml + Parenteral nutrition (binary mixture)
injectionInsulin Glucose-lowering
Compatible 2 UI/ml + Parenteral nutrition (binary mixture)
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
injectionMidazolam hydrochloride Anxiolytic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 5 mg/ml + Parenteral nutrition (binary mixture)
injectionPapaverine hydrochloride Vasodilator
Incompatible 20 mg/ml + Parenteral nutrition (binary mixture)
injectionPethidine hydrochloride Analgesic
Compatible 50 mg/ml + Parenteral nutrition (binary mixture)
injectionPhenytoin sodium Antiepileptic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 50 mg/ml + Parenteral nutrition (binary mixture)
injectionPotassium chloride Electrolyte
Compatible 400 mEq/l + Parenteral nutrition (binary mixture)
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2.5 mg/ml + Parenteral nutrition (binary mixture)
injectionSalbutamol sulfate Beta-stimulant
Compatible 0.5 mg/ml + Parenteral nutrition (binary mixture)
injectionTicarcillin / clavulanic acid Antibiotic
Compatible 30 mg/ml + Parenteral nutrition (binary mixture)
injectionVancomycin hydrochloride Antibiotic
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
injectionVecuronium bromide Curarimimetic
Compatible 2 mg/ml + Parenteral nutrition (binary mixture)

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