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References   References 814  
Type : Journal
Research teams : Ann Arbor - University of Michigan, College of Pharmacy
Authors : Johnson CE, VandenBussche HL, Chio CC, Jacobson PA.
Title : Stability of tacrolimus with morphine sulfate, hydromorphone hydrochloride, and ceftazidime during simulated intravenous coadministration.
Reference : Am J Health-Syst Pharm ; 56: 164-169. 1999
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionCeftazidime Antibiotic
Compatible 20 & 100 mg/ml + InjectionTacrolimus 5 & 20 µg/ml + Glucose 5%
InjectionHydromorphone hydrochloride Analgesic
Compatible 0,1 & 1 mg/ml + InjectionTacrolimus 5 & 20 µg/ml + Glucose 5%
InjectionMorphine sulfate Analgesic
Compatible 0,5 & 1,5 mg/ml + InjectionTacrolimus 5 & 20 µg/ml + Sodium chloride 0,9%
InjectionTacrolimus Immunosuppressant
Compatible 5 & 20 µg/ml + InjectionCeftazidime 20 & 100 mg/ml + Glucose 5%
Compatible 5 & 20 µg/ml + InjectionHydromorphone hydrochloride 0,1 & 1 mg/ml + Glucose 5%
Compatible 5 & 20 µg/ml + InjectionMorphine sulfate 0,5 & 1,5 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Glass Sodium chloride 0,9% 23°C-25°C Light
Injection Tacrolimus 5 & 20 µg/ml
Injection Morphine sulfate 0,5 & 1,5 mg/ml
4 Hour
Glass Glucose 5% 23°C-25°C Light
Injection Tacrolimus 5 & 20 µg/ml
Injection Hydromorphone hydrochloride 0,1 & 1 mg/ml
4 Hour
Glass Glucose 5% 23°C-25°C Light
Injection Tacrolimus 5 & 20 µg/ml
Injection Ceftazidime 20 & 100 mg/ml
4 Hour
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