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References   References 5097  
Type : Journal
Web link : https://doi.org/10.1371/ journal.pone.0330869
Research teams : Marseille - Hôpital de la Conception
Authors : Paoli-Lombardo R, Arcani V, Dazan D, Castera-Ducros C, Esteve M-A, Roudot M, Wanert C, Ovaert C, Curti C, Vanelle P, Rathelot P
Title : Stability and physical compatibility of parenteral nalbuphine hydrochloride during continuous infusion in pediatrics.
Reference : PlosOne ; e0330869. 2025
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionAmphotericin B Antifungal
Incompatible 0,5 mg/ml + injectionNalbuphine hydrochloride 0,05 >>0,33 mg/ml + Sodium chloride 0,9%
injectionFurosemide Diuretic
Incompatible 1 mg/ml + injectionNalbuphine hydrochloride 0,05 >>0,33 mg/ml + Sodium chloride 0,9%
injectionNalbuphine hydrochloride Antidote
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,05 >> 0,33 mg/ml 25°C Light
24 Hour
Incompatible 0,05 >>0,33 mg/ml + injectionAmphotericin B 0,5 mg/ml + Sodium chloride 0,9%
Incompatible 0,05 >>0,33 mg/ml + injectionFurosemide 1 mg/ml + Sodium chloride 0,9%
  Mentions Légales