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References   References 47  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/51/9/1201
Research teams : Los Angeles - University of Southern california, School of Pharmacy
Authors : Burm JP, Jhee SS, Chin A, Moon YSK.
Title : Stability of paclitaxel with ondansetron or ranitidine hydrochloride during simulated Y site administration.
Reference : Am J Hosp Pharm ; 51: 1201-1204. 1994
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products
List of drugs
InjectionOndansetron hydrochloride Antiemetic
Compatible 0.03 & 0.3 mg/ml + InjectionPaclitaxel 0.3 & 1.2 mg/ml + Glucose 5%
InjectionPaclitaxel Anticancer drug
Compatible 0.3 & 1.2 mg/ml + InjectionOndansetron hydrochloride 0.03 & 0.3 mg/ml + Glucose 5%
Compatible 0.3 & 1.2 mg/ml + InjectionRanitidine hydrochloride 0.5 & 2 mg/ml + Glucose 5%
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 0.5 & 2 mg/ml + InjectionPaclitaxel 0.3 & 1.2 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 23°C Light
Injection Paclitaxel 0,3 & 1,2 mg/ml
Injection Ondansetron hydrochloride 0,03 & 0,3 mg/ml
4 Hour
Glass Glucose 5% 23°C Light
Injection Paclitaxel 0,3 & 1,2 mg/ml
Injection Ranitidine hydrochloride 0,5 & 2 mg/ml
4 Hour
Glass Glucose 5% 23°C Light
Injection Paclitaxel 1,2 mg/ml
Injection Ondansetron hydrochloride 0,3 mg/ml
Injection Ranitidine hydrochloride 2,0 mg/ml
4 Hour
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