Last update :
19/11/2024
References   References 4301  
Type : Journal

Research teams : Hubei - Dongfeng Hospital, Hubei University of Medicine
Authors : Fang B-X, Chen F-C, Zhu D, Guo J, Wang L-H.
Title : Stability of azasetron-dexamethasone mixture for chemotherapyinduced nausea and vomiting administration.
Reference : Oncotarget ;8, 63: 106249-106257. 2017

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionAzasetron Antiemetic
Factors which affect stability Storage Light Induces Degradation
Compatible 0.1 mg/ml + injectionDexamethasone sodium phosphate 0.05 >> 0.2 mg/ml + Sodium chloride 0,9%
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 0.05 >> 0.2 mg/ml + injectionAzasetron 0.1 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Glass Sodium chloride 0,9% 25°C Protect from light
injection Azasetron 0,1 mg/ml
injection Dexamethasone sodium phosphate 0,05 & 0,1 & 0,2 mg/ml
48 Hour
Glass Sodium chloride 0,9% 4°C Protect from light
injection Azasetron 0,1 mg/ml
injection Dexamethasone sodium phosphate 0,05 & 0,1 & 0,2 mg/ml
14 Day
Polyolefine Sodium chloride 0,9% 25°C Protect from light
injection Azasetron 0,1 mg/ml
injection Dexamethasone sodium phosphate 0,05 & 0,1 & 0,2 mg/ml
48 Hour
Polyolefine Sodium chloride 0,9% 4°C Protect from light
injection Dexamethasone sodium phosphate 0,05 & 0,1 & 0,2 mg/ml
injection Azasetron 0,1 mg/ml
14 Day

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