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References   References 2016  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/62/19/1998
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Xu QA, Trissel LA.
Title : Compatibility of palonosetron with cyclophosphamide and with ifosfamide during Y-site administration.
Reference : Am J Health-Syst Pharm ; 62: 1998-2000. 2005
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
No comments for the degradation products
List of drugs
injectionCyclophosphamide Anticancer drug
Compatible 10 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
injectionIfosfamide Anticancer drug
Compatible 20 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
injectionPalonosetron hydrochloride Antiemetic
Compatible 50 µg/ml + injectionCyclophosphamide 10 mg/ml + Glucose 5%
Compatible 50 µg/ml + injectionIfosfamide 20 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 25°C Light
injection Palonosetron hydrochloride 50 µg/ml
injection Cyclophosphamide 10 mg/ml
4 Hour
Glass Glucose 5% 25°C Light
injection Palonosetron hydrochloride 50 µg/ml
injection Ifosfamide 20 mg/ml
4 Hour
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