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References   References 1603  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/58/13/1218
Research teams : West Point - Merck and Co
Authors : Bergquist PA, Manas D, Hunke WA, Reed RA.
Title : Stability and compatibility of tirofiban hydrochloride during simulated Y-site administration with other drugs.
Reference : Am J Health-Syst Pharm ; 58: 1218-1223. 2001
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionAtropine sulfate Antimuscarinic
Compatible 0,4 & 1 mg/ml + injectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
injectionDiazepam Anxiolytic
Incompatible 5 mg/ml + injectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
injectionDobutamine hydrochloride Cardiotonic
Compatible 0,25 & 5 mg/ml + injectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 2 & 100 µg/ml + injectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
injectionFurosemide Diuretic
Compatible 0,5 & 10 mg/ml + injectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
injectionMidazolam hydrochloride Anxiolytic
Compatible 0,05 & 5 mg/ml + injectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
injectionMorphine sulfate Analgesic
Compatible 0,1 & 1 mg/ml + injectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
injectionNitroglycerin Vasodilator
Compatible 0,1 & 0,4 mg/ml + injectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
injectionPropranolol hydrochloride Beta-blocker
Compatible 1 mg/ml + injectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
injectionTirofiban Anticoagulant
Compatible 50 µg/ml + injectionAtropine sulfate 0,4 & 1 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 50 µg/ml + injectionDiazepam 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + injectionDobutamine hydrochloride 0,25 & 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + injectionEpinephrine hydrochloride 2 & 100 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + injectionFurosemide 0,5 & 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + injectionMidazolam hydrochloride 0,05 & 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + injectionMorphine sulfate 0,1 & 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + injectionNitroglycerin 0,1 & 0,4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + injectionPropranolol hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Glass NaCl 0,9% or Glucose 5% 20°C-25°C Light
injection Tirofiban 50 µg/ml
injection Atropine sulfate 0,4 & 1 mg/ml
4 Hour
Glass NaCl 0,9% or Glucose 5% 20°C-25°C Light
injection Tirofiban 50 µg/ml
injection Dobutamine hydrochloride 0,25 & 5 mg/ml
4 Hour
Glass NaCl 0,9% or Glucose 5% 20°C-25°C Light
injection Tirofiban 50 µg/ml
injection Epinephrine hydrochloride 2 & 100 µg/ml
4 Hour
Glass NaCl 0,9% or Glucose 5% 20°C-25°C Light
injection Tirofiban 50 µg/ml
injection Furosemide 0,5 & 10 mg/ml
4 Hour
Glass NaCl 0,9% or Glucose 5% 20°C-25°C Light
injection Tirofiban 50 µg/ml
injection Midazolam hydrochloride 0,05 & 5 mg/ml
4 Hour
Glass NaCl 0,9% or Glucose 5% 20°C-25°C Light
injection Tirofiban 50 µg/ml
injection Morphine sulfate 0,1 & 1 mg/ml
4 Hour
Glass NaCl 0,9% or Glucose 5% 20°C-25°C Light
injection Tirofiban 50 µg/ml
injection Nitroglycerin 0,1 & 0,4 mg/ml
4 Hour
Glass NaCl 0,9% or Glucose 5% 20°C-25°C Light
injection Tirofiban 50 µg/ml
injection Propranolol hydrochloride 1 mg/ml
4 Hour
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