Bibliographie - 150 - Stabilis 4.0

Last update :
28/04/2024

References 150

Type :

Journal

Research teams :

Marseille - La Timone University Teaching Hospital, Pharmacy Department

Authors :

Aujoulat P, Coze C, Braguer D, Raybaud C.

Title :

Physicochemical compatibility of methotrexate with co-administered drugs during cancer chemotherapy regimens.

Reference :

J Pharm Clin ; 12: 31-35. 1993

Level of Evidence :

Physical stability :

Chemical stability :

Other methods :

Comments :

Not rated: compatibility study only

List of drugs

Asparaginase

120 UI/ml			+
120 UI/ml	+ Methotrexate sodium	30 mg/ml	+
120 UI/ml	+ Sodium bicarbonate	14 mg/ml	+

Ceftriaxone disodium

100 mg/ml			+
100 mg/ml	+ Methotrexate sodium	30 mg/ml	+
100 mg/ml	+ Sodium bicarbonate	14 mg/ml	+

Cyclophosphamide

20 mg/ml			+
20 mg/ml	+ Methotrexate sodium	30 mg/ml	+
20 mg/ml	+ Sodium bicarbonate	14 mg/ml	+

Cytarabine

0.6 mg/ml			+
0.6 mg/ml	+ Methotrexate sodium	30 mg/ml	+
0.6 mg/ml	+ Sodium bicarbonate	14 mg/ml	+

Daunorubicin hydrochloride

0.52 mg/ml			+
0.52 mg/ml	+ Methotrexate sodium	30 mg/ml	+
0.52 mg/ml	+ Sodium bicarbonate	14 mg/ml	+

Dexamethasone sodium phosphate

4 mg/ml

Methotrexate sodium

30 mg/ml

Doxorubicin hydrochloride


0.4 mg/ml	+ Methotrexate sodium	30 mg/ml	+
0.4 mg/ml	+ Sodium bicarbonate	14 mg/ml	+
0.4 mg/ml	+ Sodium bicarbonate		+

Etoposide

0.6 mg/ml			+
0.6 mg/ml	+ Methotrexate sodium	30 mg/ml	+
0.6 mg/ml	+ Sodium bicarbonate	14 mg/ml	+

Folinate calcium


10 mg/ml			+
10 mg/ml	+ Methotrexate sodium	30 mg/ml	+
10 mg/ml	+ Sodium bicarbonate	14 mg/ml	+

Heparin sodium

500 UI/ml			+
500 UI/ml	+ Methotrexate sodium	30 mg/ml	+
500 UI/ml	+ Sodium bicarbonate	14 mg/ml	+

Ifosfamide

36 mg/ml

Methotrexate sodium

30 mg/ml

Imipenem - cilastatin sodium

Mesna

1.8 mg/ml	+ Methotrexate sodium	30 mg/ml	+
1.8 mg/ml			+
1.8 mg/ml	+ Sodium bicarbonate	14 mg/ml	+

Methotrexate sodium

30 mg/ml	+ Asparaginase	120 UI/ml	+
30 mg/ml	+ Ceftriaxone disodium	100 mg/ml	+
30 mg/ml	+ Cyclophosphamide	20 mg/ml	+
30 mg/ml	+ Cytarabine	0.6 mg/ml	+
30 mg/ml	+ Daunorubicin hydrochloride	0.52 mg/ml	+
30 mg/ml	+ Dexamethasone sodium phosphate	4 mg/ml	+
30 mg/ml	+ Doxorubicin hydrochloride	0.4 mg/ml	+
30 mg/ml	+ Etoposide	0.6 mg/ml	+
30 mg/ml	+ Folinate calcium	10 mg/ml	+
30 mg/ml	+ Heparin sodium	500 UI/ml	+
30 mg/ml	+ Ifosfamide	36 mg/ml	+
30 mg/ml	+ Mesna	1.8 mg/ml	+
30 mg/ml	+ Midazolam hydrochloride	5 mg/ml	+
30 mg/ml	+ Nalbuphine hydrochloride	10 mg/ml	+
30 mg/ml	+ Ondansetron hydrochloride	2 mg/ml	+
30 mg/ml	+ Oxacillin sodium	250 mg/ml	+
30 mg/ml	+ Paracetamol	200 mg/ml	+
30 mg/ml	+ Vancomycin hydrochloride	5 mg/ml	+
30 mg/ml	+ Vincristine sulfate	0.1 mg/ml	+
30 mg/ml	+ Vindesine sulfate	0.1 mg/ml	+

Midazolam hydrochloride


5 mg/ml			+
5 mg/ml	+ Methotrexate sodium	30 mg/ml	+
5 mg/ml	+ Sodium bicarbonate	14 mg/ml	+

Nalbuphine hydrochloride


10 mg/ml	+ Methotrexate sodium	30 mg/ml	+
10 mg/ml	+ Sodium bicarbonate	14 mg/ml	+
10 mg/ml			+

Ondansetron hydrochloride


2 mg/ml			+
2 mg/ml	+ Methotrexate sodium	30 mg/ml	+
2 mg/ml	+ Sodium bicarbonate	14 mg/ml	+

Oxacillin sodium


250 mg/ml			+
250 mg/ml			+
250 mg/ml	+ Methotrexate sodium	30 mg/ml	+
250 mg/ml	+ Sodium bicarbonate	14 mg/ml	+

Paracetamol

200 mg/ml			+
200 mg/ml	+ Methotrexate sodium	30 mg/ml	+
200 mg/ml	+ Sodium bicarbonate	14 mg/ml	+

Sodium bicarbonate

14 mg/ml	+ Asparaginase	120 UI/ml	+
14 mg/ml	+ Ceftriaxone disodium	100 mg/ml	+
14 mg/ml	+ Cyclophosphamide	20 mg/ml	+
14 mg/ml	+ Cytarabine	0.6 mg/ml	+
14 mg/ml	+ Daunorubicin hydrochloride	0.52 mg/ml	+
14 mg/ml	+ Doxorubicin hydrochloride	0.4 mg/ml	+
	+ Doxorubicin hydrochloride	0.4 mg/ml	+
14 mg/ml	+ Etoposide	0.6 mg/ml	+
14 mg/ml	+ Folinate calcium	10 mg/ml	+
14 mg/ml	+ Heparin sodium	500 UI/ml	+
14 mg/ml	+ Mesna	1.8 mg/ml	+
14 mg/ml	+ Midazolam hydrochloride	5 mg/ml	+
14 mg/ml	+ Nalbuphine hydrochloride	10 mg/ml	+
14 mg/ml	+ Ondansetron hydrochloride	2 mg/ml	+
14 mg/ml	+ Oxacillin sodium	250 mg/ml	+
14 mg/ml	+ Paracetamol	200 mg/ml	+
14 mg/ml	+ Vincristine sulfate	0.1 mg/ml	+
14 mg/ml	+ Vindesine sulfate	0.1 mg/ml	+

Vancomycin hydrochloride

5 mg/ml

Methotrexate sodium

30 mg/ml

Vincristine sulfate


0.1 mg/ml			+
0.1 mg/ml	+ Methotrexate sodium	30 mg/ml	+
0.1 mg/ml	+ Sodium bicarbonate	14 mg/ml	+

Vindesine sulfate


0.1 mg/ml			+
0.1 mg/ml	+ Methotrexate sodium	30 mg/ml	+
0.1 mg/ml	+ Sodium bicarbonate	14 mg/ml	+

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