Last update :
28/04/2024
References   References 1333  
Type : Journal

Research teams : Brentford - Beecham Pharmaceuticals, Formulation Development Department
Authors : Cook B, Hill SA, Lynn B.
Title : The stability of amoxycillin sodium in intravenous infusion fluids.
Reference : J Clin Hosp Pharm ; 7: 245-250. 1982

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
No comments for the degradation products

List of drugs
InjectionAmoxicillin sodium Antibiotic
Factors which affect stability Solvent Sodium chloride 0,9% Induces Enhanced stability
Factors which affect stability Concentration Increase Induces Reduced stability
Stability in solutions Not specified Water for Injection 10 & 20 mg/ml 25°C Not specified
8 Hour
Stability in solutions Not specified Water for Injection 50 mg/ml 25°C Not specified
3 Hour
Stability in solutions Not specified Sodium chloride 0,9% 10 & 20 mg/ml 25°C Not specified
8 Hour
Stability in solutions Not specified Sodium chloride 0,9% 50 mg/ml 25°C Not specified
3 Hour
Stability in solutions Not specified Glucose 5% 10 mg/ml 25°C Not specified
2 Hour
Stability in solutions Not specified Glucose 5% 50 mg/ml 25°C Not specified
1 Hour

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