Last update :
19/11/2024
References   References 1041  
Type : Journal

Research teams : Ann Arbor - Saint Joseph Mercy Hospital, Pharmacy Department
Authors : Hasegawa GR, Eder JF.
Title : Visual compatibility of dobutamine hydrochloride with other injectable drugs.
Reference : Am J Hosp Pharm ; 41: 949-951. 1984

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionAminophylline Various
Incompatible 5 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionAmiodarone hydrochloride Anti-arrhythmic
Compatible 5 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionAtropine sulfate Antimuscarinic
Compatible 0.1 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionBretylium tosilate Anti-arrhythmic
Compatible 8 & 50 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionBumetanide Diuretic
Incompatible 0.25 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionCalcium chloride Electrolyte
Compatible 100 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionCalcium gluconate Electrolyte
Incompatible 100 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionDiazepam Anxiolytic
Incompatible 5 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionDobutamine hydrochloride Cardiotonic
Factors which affect stability Solvent NaHCO3 Induces Degradation
Compatible 2 mg/ml + injectionLidocaine hydrochloride 8 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionMetaraminol 0.2 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionMorphine sulfate 10 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionNitroglycerin 0.24 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionNorepinephrine bitartrate 0.064 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionPethidine hydrochloride 100 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionPhentolamine mesylate 0.04 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionPhenylephrine hydrochloride 0.04 mg/ml + Glucose 5%
Incompatible 2 mg/ml + injectionPhenytoin sodium 50 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionPotassium chloride 40 mEq/l + Glucose 5%
Compatible 2 mg/ml + injectionProcainamide hydrochloride 8 & 100 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionPropranolol hydrochloride 1 mg/ml + Glucose 5%
Incompatible 2 mg/ml + injectionSodium bicarbonate 84 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionVerapamil hydrochloride 2.5 mg/ml + Glucose 5%
Incompatible 2 mg/ml + NaHCO3
Incompatible 2 mg/ml + injectionAminophylline 5 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionAmiodarone hydrochloride 5 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionAtropine sulfate 0.1 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionBretylium tosilate 8 & 50 mg/ml + Glucose 5%
Incompatible 2 mg/ml + injectionBumetanide 0.25 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionCalcium chloride 100 mg/ml + Glucose 5%
Incompatible 2 mg/ml + injectionCalcium gluconate 100 mg/ml + Glucose 5%
Incompatible 2 mg/ml + injectionDiazepam 5 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionDopamine hydrochloride 1.6 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionEpinephrine hydrochloride 0.1 µg/ml + Glucose 5%
Incompatible 2 mg/ml + injectionFurosemide 10 mg/ml + Glucose 5%
Incompatible 2 mg/ml + injectionHeparin sodium 10000 UI/ml + Glucose 5%
Compatible 2 mg/ml + injectionHeparin sodium 100 UI/ml + Glucose 5%
Incompatible 2 mg/ml + injectionInsulin 100 UI/ml + Glucose 5%
Compatible 2 mg/ml + injectionIsoprenaline hydrochloride 0.004 mg/ml + Glucose 5%
injectionDopamine hydrochloride Cardiotonic
Compatible 1.6 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 0.1 µg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionFurosemide Diuretic
Incompatible 10 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionHeparin sodium Anticoagulant
Compatible 100 UI/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
Incompatible 10000 UI/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionInsulin Glucose-lowering
Incompatible 100 UI/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionIsoprenaline hydrochloride Beta-stimulant
Compatible 0.004 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionLidocaine hydrochloride Local anesthetic
Compatible 8 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionMetaraminol Sympathomimetic
Compatible 0.2 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionMorphine sulfate Analgesic
Compatible 10 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionNitroglycerin Vasodilator
Compatible 0.24 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 0.064 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionPethidine hydrochloride Analgesic
Compatible 100 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionPhentolamine mesylate Vasodilator
Compatible 0.04 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionPhenylephrine hydrochloride Sympathomimetic
Compatible 0.04 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionPhenytoin sodium Antiepileptic
Incompatible 50 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionPotassium chloride Electrolyte
Compatible 40 mEq/l + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionProcainamide hydrochloride Anti-arrhythmic
Compatible 8 & 100 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionPropranolol hydrochloride Beta-blocker
Compatible 1 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionSodium bicarbonate Electrolyte
Incompatible 84 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
injectionVerapamil hydrochloride Anti-arrhythmic
Compatible 2.5 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%

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