Last update :
19/11/2024
References   References 1039  
Type : Journal

Research teams : Bethesda - National Institutes of Health Clinical Center
Authors : Cheung YW, Vishnuvajjala BR, Morris NL, Flora KP.
Title : Stability of azacitidine in infusion fluids.
Reference : Am J Hosp Pharm ; 41: 1156-1159. 1984

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
No comments for the degradation products
No visual inspection
Unencrypted results (eg graphic)

List of drugs
injectionAzacitidine Anticancer drug
Factors which affect stability Solvent Glucose 5% Induces Degradation
Stability in solutions Glass Sodium chloride 0,9% 0.2 mg/ml 25°C Not specified
1.9 Hour
Stability in solutions Glass Sodium chloride 0,9% 2 mg/ml 25°C Not specified
2.4 Hour
Stability in solutions Glass Ringer’s lactate solution 0.2 mg/ml 25°C Not specified
1.9 Hour
Stability in solutions Glass Ringer’s lactate solution 2 mg/ml 25°C Not specified
2.8 Hour
Incompatible + Glucose 5%

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