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References   References 642  
Type : Journal
Research teams : Gainesville - University of Florida, College of Pharmacy
Authors : Baumgartner TG, Knudsen AK, Dunn AJ, Kilroy RA.
Title : Norepinephrine stability in saline solutions.
Reference : Hosp Pharm ; 23: 44,49, 59. 1988
Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - Electrochemical detector
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
No visual inspection
List of drugs
injectionAmobarbital sodium General anesthetic
Incompatible + injectionNorepinephrine bitartrate
injectionChlorothiazide sodium Diuretic
Incompatible + injectionNorepinephrine bitartrate
injectionNorepinephrine bitartrate Sympathomimetic
Factors which affect stability Solvent NaHCO3 Induces Degradation
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,004 & 0,008 mg/ml 25°C Light
24 Hour
Incompatible + injectionAmobarbital sodium
Incompatible + injectionChlorothiazide sodium
Incompatible + injectionPentobarbital sodium
Incompatible + injectionPhenobarbital sodium
Incompatible + injectionPhenytoin sodium
Incompatible + injectionSodium bicarbonate
Incompatible + injectionStreptomycin sulfate
Incompatible 0.128 mg/ml + injectionThiopental sodium 25 mg/ml
Incompatible + NaHCO3
injectionPentobarbital sodium General anesthetic
Incompatible + injectionNorepinephrine bitartrate
injectionPhenobarbital sodium Antiepileptic
Incompatible + injectionNorepinephrine bitartrate
injectionPhenytoin sodium Antiepileptic
Incompatible + injectionNorepinephrine bitartrate
injectionSodium bicarbonate Electrolyte
Incompatible + injectionNorepinephrine bitartrate
injectionStreptomycin sulfate Antibiotic
Incompatible + injectionNorepinephrine bitartrate
injectionThiopental sodium General anesthetic
Incompatible 25 mg/ml + injectionNorepinephrine bitartrate 0.128 mg/ml
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