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References   References 104  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/54/2/185
Research teams : Charleston - Medical University of South Carolina
Authors : Hall PD, Yui D, Lyons S, Bosso JA.
Title : Compatibility of filgrastim with selected antimicrobial drugs during simulated Y-site administration.
Reference : Am J Health-Syst Pharm ; 54: 185-189. 1997
Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Degradation products not observed in real conditions
List of drugs
injectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + injectionFilgrastim 40 µg/ml + Glucose 5%
injectionCeftazidime Antibiotic
Incompatible 10 mg/ml + injectionFilgrastim 40 µg/ml + Glucose 5%
injectionFilgrastim Various
Compatible 40 µg/ml + injectionAmikacin sulfate 5 mg/ml + Glucose 5%
Incompatible 40 µg/ml + injectionCeftazidime 10 mg/ml + Glucose 5%
Compatible 40 µg/ml + injectionFluconazole 2 mg/ml + Glucose 5%
Compatible 40 µg/ml + injectionGentamicin sulfate 1.6 mg/ml + Glucose 5%
Incompatible 40 µg/ml + injectionImipenem - cilastatin sodium 5/5 mg/ml + Glucose 5%
Compatible 40 µg/ml + injectionTobramycin sulfate 1.6 mg/ml + Glucose 5%
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionFilgrastim 40 µg/ml + Glucose 5%
injectionGentamicin sulfate Antibiotic
Compatible 1.6 mg/ml + injectionFilgrastim 40 µg/ml + Glucose 5%
injectionImipenem - cilastatin sodium Antibiotic
Incompatible 5/5 mg/ml + injectionFilgrastim 40 µg/ml + Glucose 5%
injectionTobramycin sulfate Antibiotic
Compatible 1.6 mg/ml + injectionFilgrastim 40 µg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 25°C Not specified
injection Filgrastim 40 µg/ml
injection Amikacin sulfate 10 mg/ml
4 Hour
Glass Glucose 5% 25°C Not specified
injection Filgrastim 40 µg/ml
injection Gentamicin sulfate 3,2 mg/ml
4 Hour
Glass Glucose 5% 25°C Not specified
injection Filgrastim 40 µg/ml
injection Tobramycin sulfate 3,2 mg/ml
4 Hour
Glass Glucose 5% 25°C Not specified
injection Filgrastim 40 µg/ml
injection Ceftazidime 5 mg/ml
4 Hour
Glass Glucose 5% 25°C Not specified
injection Filgrastim 40 µg/ml
injection Fluconazole 1 mg/ml
4 Hour
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