Last update :
29/10/2024
Anticoagulant   Defibrotide  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Defitelio Belgium, Brazil, France, Germany, Great Britain, Hungary, Ireland, Italy, Japan, Norway, Romania, Slovenia, Sweden, Switzerland, United States of America
Compatibility   injection   Compatibility : Defibrotide              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
injection Defibrotide 8 mg/ml
injection Aciclovir sodium 10 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Alizapride hydrochloride 0.96 mg/ml
Sodium chloride 0,9% 3728
Immediate precipitation Incompatible
injection Defibrotide 8 mg/ml
injection Amikacin sulfate 5 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Amoxicillin sodium 40 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Amphotericin B liposomale 2 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Caspofungin acetate 0.4 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Ceftazidime 80 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Ceftriaxone disodium 100 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Ciclosporin 1.27 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Ciprofloxacin lactate 2 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Clonazepam 0.02 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Clonidine hydrochloride 0.0024 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Co-trimoxazole 0.64/3.2 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Deferoxamine mesylate 6.7 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Fluconazole 2 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Foscarnet sodium 24 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Fosfomycin 40 mg/ml
Sodium chloride 0,9% 3728
Production of gas bubbles Incompatible
injection Defibrotide 8 mg/ml
injection Furosemide 10 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Ganciclovir sodium 10 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Heparin sodium 373 UI/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Human albumin 200 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Hydrocortisone sodium succinate 1.9 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Hydroxyzine dihydrochloride 0.79 mg/ml
Sodium chloride 0,9% 3728
Unspecified incompatibility Incompatible
injection Defibrotide 8 mg/ml
injection Imipenem - cilastatin sodium 9.94/9.94 mg/ml
Glucose 5% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Imipenem - cilastatin sodium 9.94/9.94 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Mesna 4.76 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Methylprednisolone sodium succinate 10 mg/ml
Sodium chloride 0,9% 3728
Unspecified incompatibility Incompatible
injection Defibrotide 8 mg/ml
injection Methylprednisolone sodium succinate 10 mg/ml
Glucose 5% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Metronidazole 5 mg/ml
Sodium chloride 0,9% 3728
Precipitation after 2 hours Incompatible
injection Defibrotide 8 mg/ml
injection Midazolam hydrochloride 5 mg/ml
Sodium chloride 0,9% 3728
Immediate precipitation Incompatible
injection Defibrotide 8 mg/ml
injection Mycophenolate mofetil 11.9 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Nalbuphine hydrochloride 2 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Naloxone hydrochloride 0.4 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Nefopam 5 mg/ml
Sodium chloride 0,9% 3728
Precipitation after 1 hour Incompatible
injection Defibrotide 8 mg/ml
injection Nicardipine hydrochloride 0.5 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Ondansetron hydrochloride 0.16 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Pantoprazole sodium 1.6 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Paracetamol 10 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Phloroglucinol 10 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Teicoplanine 125 mg/ml
Sodium chloride 0,9% 3728
Immediate precipitation Incompatible
injection Defibrotide 8 mg/ml
injection Tobramycin sulfate 10 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Defibrotide 8 mg/ml
injection Tranexamic acid 100 mg/ml
Sodium chloride 0,9% 3728
Immediate precipitation Incompatible
injection Defibrotide 8 mg/ml
injection Vancomycin hydrochloride 10.4 mg/ml
Sodium chloride 0,9% 3728

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