Last update :
19/11/2024
Anticancer drug   Carmustine  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Becenun Brazil
Bicnu Australia, Canada, Chile, Colombia, France, Great Britain, Greece, Hungary, Iran, Ireland, Mexico, Morocco, New Zealand, Peru, Romania, Spain, Switzerland, Tunisia, United States of America
Bodacler Argentina
Carmubris Austria, Germany, Iran
Carmustina Grey Peru
Carmustina Perulab Peru
Carmustine Baxter New Zealand
Carmustine Obvius Austria, Belgium, Bulgaria, Croatia, Czech Republic, Denmark, Finland, France, Germany, Great Britain, Hungary, Iceland, Ireland, Luxembourg, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden
Nitrourean Spain
Nitrumon Belgium, Iran, Luxembourg
References   injection   References : Carmustine  
Type Publication
3 Journal Trissel LA, Martinez JF.
Compatibility of amifostine with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1995 ; 52: 2208-2212.
81 Journal Trissel LA, Martinez JF.
Compatibility of piperacillin sodium plus tazobactam with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1994 ; 51: 672-678.
84 Journal Trissel LA, Martinez JF.
Visual, turbidimetric, and particle-content assessment of compatibility of vinorelbine tartrate with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1994 ; 51: 495-499.
99 Journal Trissel LA, Martinez JF.
Compatibility of aztreonam with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1995 ; 52: 1086-1090.
146 Journal Hadji-Minaglou-Gonzalvez MF, Gayte-Sorbier A, Airauto CB, Verdier M.
Effects of temperature, solution composition, and type of container on the stability and absorption of carmustine.
Clin Ther 1992 ; 14: 821-824.
169 Journal Trissel LA, Martinez JF.
Physical compatibility of melphalan with selected drugs during simulated Y-site administration.
Am J Hosp Pharm 1993 ; 50: 2359-2363.
182 Journal Trissel LA, Gilbert DL, Martinez JF.
Compatibility of granisetron hydrochloride with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 56-60.
244 Journal Trissel LA, Martinez JF.
Compatibility of filgrastim with selected drugs during simulated Y-site administration.
Am J Hosp Pharm 1994 ; 51: 1907-1913.
249 Journal Trissel LA, Martinez JF.
Compatibility of thiotepa (lyophilized) with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1996 ; 53: 1041-1045.
307 Journal Trissel LA, Martinez JF.
Compatibility of allopurinol sodium with selected drugs during simulated Y-site administration.
Am J Hosp Pharm 1994 ; 51: 1792-1799.
334 Journal Trissel LA, Tramonte SM, Grilley BJ.
Visual compatibility of ondansetron hydrochloride with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1991 ; 48: 988-992.
335 Journal Trissel LA, Bready BB, Kwan JW, Santiago NM.
Visual compatibility of sargramostim with selected antineoplasic agents, anti-infectives, or other drugs during simulated Y-site injection.
Am J Hosp Pharm 1992 ; 49: 402-406.
492 Journal Trissel LA, Parks NPT, Santiago NM.
Visual compatibility of fludarabine phosphate with antineoplastic drugs, anti-infectives, and other selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1991 ; 48: 2186-2189.
715 Journal Colvin M, Hartner J, Summerfield M.
Stability of carmustine in the presence of sodium bicarbonate.
Am J Hosp Pharm 1980 ; 37: 677-678.
837 Journal Fredriksson K, Lundgren P, Landersjo L.
Stability of carmustine - kinetics and compatibility during administration.
Acta Pharm Suec 1986 ; 23: 115-124.
905 Journal Trissel LA, Martinez JF.
Screening teniposide for Y-site physical incompatibilities.
Hosp Pharm 1994 ; 29: 1010-1017.
1410 Journal Trissel LA, Martinez JF, Simmons M.
Compatibility of etoposide phosphate with selected drugs during simulated Y-site injection.
J Am Pharm Assoc 1999 ; 39: 141-145.
1423 Journal Trissel LA, Martinez JF, Gilbert DL.
Compatibility of gemcitabine hyrochloride with 107 selected drugs during simulated Y-site injection.
J Am Pharm Assoc 1999 ; 39: 514-518.
1501 Journal Beitz C, Bertsch T, Hannak D, Schrammel W, Einberger C, Wehling M.
Compatibility of plastics with cytotoxic drug solutions - comparison of polyethylene with other container materials.
Int J Pharm 1999 ; 185: 113-121.
1520 Manufacturer Etude de stabilité des médicaments en Ecoflac®
B Braun 2001
1622 Journal Favier M, De Casanove F, Coste A, Cherti N, Bressolle F.
Stability of carmustine in polyvinyl chloride bags and polyethylene-lined trilayer plastic containers.
Am J Health-Syst Pharm 2001 ; 58: 238-241.
2146 Journal Trissel LA, Xu QA, Baker M.
Drug compatibility with new polyolefin infusion solution containers.
Am J Health-Syst Pharm 2006 ; 63: 2379-2382.
3314 Manufacturer Carmustine (Bicnu®) – Résumé des caractéristiques du produits
Bristol Myers Squibb 2011
4762 Journal Knoll L, Kraemer I, Thiesen J.
Physicochemical stability of carmustine-containing medicinal products after reconstitution and after dilution to ready-to-administer infusion solutions stored refrigerated or at room temperature
EJHP 2023 ; 30, 1: 11-16.

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