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Anticancer drug   Fluorouracil  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Acoflut Mexico
Adrucil United States of America
Eurofluor Germany
Fivocil India
Fivoflu India, Mexico
Fluorouracil Austria, Belgium, Brazil, Canada, Denmark, Finland, Great Britain, Greece, Hungary, Italy, Netherlands, Norway, Poland, Portugal, Republic of South Africa, Serbia, Spain, Switzerland, Turkey, United States of America
Fluorouracile France
Flurablastin Denmark, Finland, Norway, Sweden
Fluracedyl Belgium, Luxembourg, Malaysia, Netherlands
Fluroblastin Republic of South Africa
Fluroblastine Belgium
Flurox Mexico
Neofluor Germany
Neoflur Egypt
Oncofu Argentina
Ribofluor Germany
Triosules Argentina
Stability in solutions   injection   Stability in solutions : Fluorouracil     
Container Solvent Concentration Temperature Storage Duration of stability References
Glass NaCl 0,9% or Glucose 5% 1,44 mg/ml 23°C Protect from light
72 Hour
1501
Level of evidence A
Glass NaCl 0,9% or Glucose 5% 1,44 mg/ml 4°C Protect from light
72 Hour
1501
Level of evidence A
Glass NaCl 0,9% or Glucose 5% 1,5 mg/ml 25°C With or without light
56 Day
840
Level of evidence D
Glass Sodium chloride 0,9% 5 mg/ml 2-8°C Protect from light
91 Day
110
Level of evidence A
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,5 & 5 mg/ml 25°C Light
13 Day
39
Level of evidence C
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,5 & 5 mg/ml 4°C Protect from light
13 Day
39
Level of evidence C
Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 & 10 mg/ml 21°C Light
14 Day
1475
Level of evidence C
Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 & 10 mg/ml 4°C Protect from light
14 Day
1475
Level of evidence C
Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,44 mg/ml 23°C Protect from light
72 Hour
1501
Level of evidence A
Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,44 mg/ml 4°C Protect from light
72 Hour
1501
Level of evidence A
Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,5 mg/ml 25°C With or without light
56 Day
840
Level of evidence D
Polyvinyl chloride NaCl 0,9% or Glucose 5% 10 mg/ml 4°C Protect from light
30 Day
40
Level of evidence D
Polyvinyl chloride Sodium chloride 0,9% 5 mg/ml 2-8°C Protect from light
91 Day
110
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 8 mg/ml -20°C Protect from light
79 Day
2323
Level of evidence A+
Polyvinyl chloride Sodium chloride 0,9% 8 mg/ml 5°C Protect from light
28 Day
2323
Level of evidence A+
Polyvinyl chloride Glucose 5% 1 & 10 mg/ml 25°C With or without light
72 Hour
842
Level of evidence C
Polyvinyl chloride Glucose 5% 1 & 10 mg/ml 4°C With or without light
72 Hour
842
Level of evidence C
Polyvinyl chloride Glucose 5% 10 mg/ml 25°C Light
112 Day
1040
Level of evidence D
Polyvinyl chloride Glucose 5% 10 mg/ml 5°C Protect from light
112 Day
1040
Level of evidence D
Polyvinyl chloride None 25 mg/ml 37°C Protect from light
14 Day
484
Level of evidence A
Polyvinyl chloride None 25 mg/ml 4°C Protect from light
14 Day
484
Level of evidence A
Polyvinyl chloride None 50 mg/ml 25°C Protect from light
7 Day
415
Level of evidence A+
Polyvinyl chloride None 50 mg/ml 33°C Protect from light
14 Day
1475
Level of evidence C
Polyvinyl chloride None 50 mg/ml 37°C Protect from light
7 Day
415
Level of evidence A+
Polyethylene NaCl 0,9% or Glucose 5% 1,44 mg/ml 21-22°C Not specified
48 Hour
1520
Manufacturer's stability data
Polyethylene NaCl 0,9% or Glucose 5% 1,44 mg/ml 23°C Protect from light
72 Hour
1501
Level of evidence A
Polyethylene NaCl 0,9% or Glucose 5% 1,44 mg/ml 4°C Protect from light
72 Hour
1501
Level of evidence A
Polyethylene NaCl 0,9% or Glucose 5% 1,44 mg/ml 4°C Not specified
48 Hour
1520
Manufacturer's stability data
Polyolefine Sodium chloride 0,9% 7 mg/ml 21-25°C Not specified
17 Day
4735
Level of evidence C+
Polyolefine Sodium chloride 0,9% 8 mg/ml 21-25°C Not specified
24 Day
4735
Level of evidence C+
Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 10 mg/ml 22°C Protect from light
28 Day
142
Joker
Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 10 mg/ml 25°C Protect from light
28 Day
844
Joker
Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 10 mg/ml 35°C Protect from light
28 Day
142
Joker
Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 10 mg/ml 35°C Protect from light
28 Day
844
Joker
Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 10 mg/ml 4°C Protect from light
28 Day
844
Joker
Ethylene vinyl acetate Sodium chloride 0,9% 15 & 45 mg/ml 25°C Protect from light
3 Day
33
Level of evidence C
Ethylene vinyl acetate None 50 mg/ml 22°C Protect from light
28 Day
142
Joker
Ethylene vinyl acetate None 50 mg/ml 25°C Protect from light
28 Day
844
Joker
Ethylene vinyl acetate None 50 mg/ml 33°C Protect from light
14 Day
1475
Level of evidence C
Ethylene vinyl acetate None 50 mg/ml 35°C Protect from light
28 Day
142
Joker
Ethylene vinyl acetate None 50 mg/ml 35°C Protect from light
28 Day
844
Joker
Polypropylen Syringe NaCl 0,9% or Glucose 5% 12 & 40 mg/ml 25°C Protect from light
3 Day
33
Level of evidence C
Polypropylen Syringe Sodium chloride 0,9% 0,1 mg/ml -10°C Protect from light
7 Day
1812
Level of evidence A
Polypropylen Syringe Sodium chloride 0,9% 0,1 mg/ml 25°C Light
7 Day
1812
Level of evidence A
Polypropylen Syringe Sodium chloride 0,9% 0,1 mg/ml 40°C Protect from light
7 Day
1812
Level of evidence A
Polypropylen Syringe Sodium chloride 0,9% 0,1 mg/ml 5°C Protect from light
7 Day
1812
Level of evidence A
Polypropylen Syringe None 25 mg/ml 2-8°C Protect from light
84 Day
3670
Level of evidence A+
Polypropylen Syringe None 50 mg/ml 30°C Not specified
21 Day
5
Level of evidence B
Polyisoprene elastomer Glucose 5% 5 & 30 mg/ml 25°C Not specified
60 Day
4759
Level of evidence A
Polyisoprene elastomer Glucose 5% 5 & 30 mg/ml 33°C Not specified
7 Day
4759
Level of evidence A
Polyisoprene elastomer Glucose 5% 8,3 mg/ml 5°C Protect from light
112 Day
1040
Level of evidence D
Polyisoprene elastomer None 50 mg/ml 25°C Not specified
60 Day
4759
Level of evidence A
Polyisoprene elastomer None 50 mg/ml 33°C Not specified
7 Day
4759
Level of evidence A
Silicone elastomer NaCl 0,9% or Glucose 5% 25 mg/ml 25°C Not specified
21 Day
1817
Level of evidence C
Silicone elastomer NaCl 0,9% or Glucose 5% 25 mg/ml 31°C Not specified
21 Day
1817
Level of evidence C
Silicone elastomer NaCl 0,9% or Glucose 5% 25 mg/ml 4°C Not specified
14 Day
1817
Level of evidence C
Silicone elastomer Sodium chloride 0,9% 35 mg/ml 21-25°C Light
28 Day
4568
Level of evidence D
Silicone elastomer Sodium chloride 0,9% 35 mg/ml 30°C Light
3 Day
4568
Level of evidence D
Silicone elastomer Sodium chloride 0,9% 44 mg/ml 21-25°C Light
28 Day
4568
Level of evidence D
Silicone elastomer Sodium chloride 0,9% 44 mg/ml 30°C Light
3 Day
4568
Level of evidence D
Silicone elastomer None 50 mg/ml 25°C Not specified
21 Day
1817
Level of evidence C
Silicone elastomer None 50 mg/ml 31°C Not specified
21 Day
1817
Level of evidence C
Not specified None 50 mg/ml 37°C Protect from light
56 Day
1842
Level of evidence C
  Mentions Légales