Last update :
21/03/2023
References   References 4735  
Type : Journal
Web link : 10.1177/10781552231152618

Research teams : Mont Godinne - Drug Stability Research Group (DSRG) - CHU UCL NAMUR, site de Godinne
Authors : Closset M, Onorati S, Colsoul M-L, Goderniaux N, Bihin B, Jamart J, Soumoy L, Hecq J-D, Odou P, Galanti L.
Title : Long-term physicochemical stability of 5-fluorouracil at selected standardised rounded doses in polyolefin bags.
Reference : J Oncol Pharm Practice 2023

Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Turbidimetry Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
InjectionFluorouracil Anticancer drug
Stability in solutions Polyolefine Sodium chloride 0,9% 7 mg/ml 21-25°C Not specified
17 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 8 mg/ml 21-25°C Not specified
24 Day

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