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19/11/2024
φάρμακο κατά του καρκίνου   Fluorouracil  
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Σταθερότητα διαλυμάτων Σταθερότητα σε μίγματα Παράγοντας που επηρεάζει τη σταθερότητα Συμβατότητες Τρόπος χορήγησης Βιβλιογραφία pdf
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Εμπορική ονομασία   Εμπορική ονομασία     

Οι εμπορικές ονομασίες είναι ενδεικτικές και η σύνθεση των εκδόχων μπορεί να διαφέρει ανάλογα με τη χώρα και τα εργαστήρια

Acoflut Μεξικό
Adrucil Η.Π.Α.
Eurofluor Γερμανία
Fivocil Ινδία
Fivoflu Ινδία, Μεξικό
Fluorouracil Αυστρία, Βέλγιο, Βραζιλία, Γιουγκοσλαβία, Δανία, Ελβετία, Ελλάδα, Η.Π.Α., Ισπανία, Ιταλία, Καναδάς, Μεγάλη Βρετανία, Νορβηγία, Νότιος Αφρική, Ολλανδία, Ουγγαρία, Πολωνία, Πορτογαλία, Τουρκία, Φινλανδία
Fluorouracile Γαλλία
Flurablastin Δανία, Νορβηγία, Σουηδία, Φινλανδία
Fluracedyl Βέλγιο, Λουξεμβούργο, Μαλαισία, Ολλανδία
Fluroblastin Νότιος Αφρική
Fluroblastine Βέλγιο
Flurox Μεξικό
Neofluor Γερμανία
Neoflur Αίγυπτος
Oncofu Αργεντινή
Ribofluor Γερμανία
Triosules Αργεντινή
Βιβλιογραφία   Ενέσιμο   Βιβλιογραφία : Fluorouracil  
τύπος δημοσίευση
3 εφημερίδα Trissel LA, Martinez JF.
Compatibility of amifostine with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1995 ; 52: 2208-2212.
5 εφημερίδα Stiles ML, Allen LV Jr, Prince SJ.
Stability of deferoxamine mesylate, floxuridine, fluorouracil, hydromorphone hydrochloride, lorazepam, and midazolam hydrochloride in polypropylene infusion-pump syringes.
Am J Health-Syst Pharm 1996 ; 53: 1583-1588.
33 εφημερίδα Baud-Camus F, Crauste-Manciet S, Klein E, Richard L, Brossard D.
Stability of fluorouracil in polypropylene syringes and ethylene vinyl acetate infusion-pump reservoirs.
Am J Health-Syst Pharm 1996 ; 53: 1457-1458.
39 εφημερίδα Farhang-Asnafi S, Callaert S, Barre J, Tillement JP, Thebault A.
Influence of intravenous admixtures on the stability of the new solution of 5-fluorouracil.
J Pharm Clin 1997 ; 16: 45-48.
40 εφημερίδα Dine T, Lebegue S, Benaji B, Gressier B, Segard V, Goudaliez F, Luyckx M, Brunet C, Mallevais ML, Kablan J, Cazin M, Cazin JC.
Stability and compatibility studies of four cytostatic agents (fluorouracil, dacarbazine, cyclophosphamide and ifosfamide) with PVC infusion bags.
Pharm Sci Communications 1994 ; 4: 97-101.
49 εφημερίδα Trissel LA, Martinez JF.
Compatibility of granisetron hydrochloride with selected alkaline drugs.
Am J Health-Syst Pharm 1995 ; 52: 208.
57 εφημερίδα Mayron D, Gennaro AR.
Stability and compatibility of granisetron hydrochloride in IV solutions and oral liquids and during simulated Y-site injection with selected drugs.
Am J Health-Syst Pharm 1996 ; 53: 294-304.
81 εφημερίδα Trissel LA, Martinez JF.
Compatibility of piperacillin sodium plus tazobactam with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1994 ; 51: 672-678.
84 εφημερίδα Trissel LA, Martinez JF.
Visual, turbidimetric, and particle-content assessment of compatibility of vinorelbine tartrate with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1994 ; 51: 495-499.
85 εφημερίδα Trissel LA, Bready BB.
Turbidimetric assessment of the compatibility of taxol with selected other drugs during simulated Y-site injection.
Am J Hosp Pharm 1992 ; 49: 1716-1719.
91 εφημερίδα Lober CA, Dollard PA.
Visual compatibility of gallium nitrate with selected drugs during Y-site injection.
Am J Hosp Pharm 1993 ; 50: 1208-1210.
99 εφημερίδα Trissel LA, Martinez JF.
Compatibility of aztreonam with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1995 ; 52: 1086-1090.
110 εφημερίδα Vincke BJ, Verstraeten AE, El Eini DID, Mc Carthy TM.
Extended stability of 5-fluorouracil and methotrexate solutions in PVC containers.
Int J Pharm 1989 ; 54: 181-189.
138 εφημερίδα Corbrion V, Crauste-Manciet S, Allain P, Brossard D.
Precipitation of fluorouracil in elastomeric infusers with a polyisoprene reservoir and in polypropylene syringes with an elastomeric joint.
Am J Health-Syst Pharm 1997 ; 54: 1845-1848.
142 εφημερίδα Rochard EB, Barthes DMC, Courtois PY.
Stability of fluorouracil, cytarabine, or doxorubicin hydrochloride in ethylene vinylacetate portable infusion-pump reservoirs.
Am J Hosp Pharm 1992 ; 49: 619-623.
153 εφημερίδα Wang DP, Chang LC, Lee DK.
Stability of fluorouracil-metoclopramide hydrochloride admixture.
Am J Health-Syst Pharm 1995 ; 52: 98-99.
155 εφημερίδα Trissel LA, Martinez JF, Xu QA.
Incompatibility of fluorouracil with leucovorin calcium or levoleucovorin calcium.
Am J Health-Syst Pharm 1995 ; 52: 710-715.
156 εφημερίδα Barberi-Hayob M, Merlin JL, Vigneron M, Conroy T.
Addition of heparin in 5-fluorouracil solution for portal vein infusion has no influence on its stability under clinically relevant conditions.
Anticancer Drugs 1995 ; 6: 163-164.
163 εφημερίδα Sewell GJ, Allsopp M, Collinson MP, Tyrrell C, Prentice AJ, Copplestone JA.
Stability studies on admixtures of 5-fluorouracil with carboplatin and 5-fluorouracil with heparin for administration in continuous infusion regimens.
J Clin Pharm Ther 1994 ; 19: 127-133.
169 εφημερίδα Trissel LA, Martinez JF.
Physical compatibility of melphalan with selected drugs during simulated Y-site administration.
Am J Hosp Pharm 1993 ; 50: 2359-2363.
182 εφημερίδα Trissel LA, Gilbert DL, Martinez JF.
Compatibility of granisetron hydrochloride with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 56-60.
244 εφημερίδα Trissel LA, Martinez JF.
Compatibility of filgrastim with selected drugs during simulated Y-site administration.
Am J Hosp Pharm 1994 ; 51: 1907-1913.
249 εφημερίδα Trissel LA, Martinez JF.
Compatibility of thiotepa (lyophilized) with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1996 ; 53: 1041-1045.
251 εφημερίδα Trissel LA, Gilbert DL, Martinez JF.
Compatibility of doxorubicin hydrochloride liposome injection with selected other drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 2708-2713.
300 εφημερίδα Trissel LA, Gilbert DL, Martinez JF.
Compatibility of propofol injectable emulsion with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 1287-1292.
301 εφημερίδα Trissel LA, Gilbert DL, Martinez JF, Baker MB, Walter WV, Mirtallo JM.
Compatibility of parenteral nutrient solutions with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 1295-1300.
307 εφημερίδα Trissel LA, Martinez JF.
Compatibility of allopurinol sodium with selected drugs during simulated Y-site administration.
Am J Hosp Pharm 1994 ; 51: 1792-1799.
334 εφημερίδα Trissel LA, Tramonte SM, Grilley BJ.
Visual compatibility of ondansetron hydrochloride with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1991 ; 48: 988-992.
335 εφημερίδα Trissel LA, Bready BB, Kwan JW, Santiago NM.
Visual compatibility of sargramostim with selected antineoplasic agents, anti-infectives, or other drugs during simulated Y-site injection.
Am J Hosp Pharm 1992 ; 49: 402-406.
411 εφημερίδα Woloschuk DMM, Wermeling JR, Pruemer JM.
Stability and compatibility of fluorouracil and mannitol during simulated Y-site administration.
Am J Hosp Pharm 1991 ; 48: 2158-2160.
413 εφημερίδα Stewart CF, Fleming RA.
Compatibility of cisplatin and fluorouracil in 0.9% sodium chloride injection.
Am J Hosp Pharm 1990 ; 47: 1373-1377.
415 εφημερίδα Stiles ML, Allen LV, Tu YH.
Stability of fluorouracil administered through four portable infusion pumps.
Am J Hosp Pharm 1989 ; 46: 2036-2040.
431 εφημερίδα McRae MP, King JC.
Compatibility of antineoplastic, antibiotic and corticosteroid drugs in intravenous admixtures.
Am J Hosp Pharm 1975 ; 33: 1010-1013.
484 εφημερίδα Northcott M, Allsopp MA, Powell H, Sewell GJ.
The stability of carboplatin, diamorphine, 5-fluorouracil and mitozantrone infusions in an ambulatory pump under storage and prolonged “in use” conditions.
J Clin Pharm Ther 1991 ; 16: 123-129.
492 εφημερίδα Trissel LA, Parks NPT, Santiago NM.
Visual compatibility of fludarabine phosphate with antineoplastic drugs, anti-infectives, and other selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1991 ; 48: 2186-2189.
513 εφημερίδα Xu QA, Trissel LA, Martinez JF.
Stability and compatibility of fluorouracil with morphine sulfate and hydromorphone hydrochloride.
Ann Pharmacotherapy 1996 ; 30: 756-761.
514 εφημερίδα Xu QA, Trissel LA, Martinez JF.
Rapid loss of fentanyl citrate admixed with fluorouracil in polyvinyl chloride containers.
Ann Pharmacotherapy 1997 ; 31: 297-302.
763 εφημερίδα Cohen MH, Jonhson-Early A, Hood MA, McKenzie M, Citron ML, Jaffe N, Krasnow SH.
Drug precipitation within IV tubing : A potential hazard of chemotherapy administration.
Cancer Treat Rep 1985 ; 69: 1325-1326.
840 εφημερίδα Biondi L, Nairn JG.
Stability of 5-fluorouracil and flucytosine in parenteral solutions.
Can J Hosp Pharm 1986 ; 39: 60-66.
842 εφημερίδα Pinguet F, Favre G, Canal P, Pujol A, Soula G.
Stability of 5-fluorouracil to heat and light.
J Pharm Clin 1990 ; 9: 155-158.
844 εφημερίδα Rochard E, Chapelle G, Bouquet S, Barthes D, Courtois PH.
Stability of fluorouracil and cytarabine in ethylvinylacetate containers.
J Pharm Clin 1989 ; 9: 31-35.
905 εφημερίδα Trissel LA, Martinez JF.
Screening teniposide for Y-site physical incompatibilities.
Hosp Pharm 1994 ; 29: 1010-1017.
921 εφημερίδα Trissel LA, Gilbert DL, Martinez JF.
Incompatibility and compatibility of amphotericin B cholesteryl sulfate complex with selected other drugs during simulated Y-site administration.
Hosp Pharm 1998 ; 33: 284-292.
1026 εφημερίδα Mayron D, Gennaro AR.
Stability and compatibility of topotecan hydrochloride with selected drugs.
Am J Health-Syst Pharm 1999 ; 56: 875-881.
1040 εφημερίδα Quebbeman EJ, Hamid AAR, Hoffman NE, Ausman RK.
Stability of fluorouracil in plastic containers used for continuous infusion at home.
Am J Hosp Pharm 1984 ; 41: 1153-1156.
1228 εφημερίδα Allen LV, Stiles ML.
Compatibility of various admixtures at Y-injection sites of intravenous administration sets. Part2.
Am J Hosp Pharm 1981 ; 38: 380-381.
1325 εφημερίδα Hardin TC, Clibon U, Page CP, Cruz AB.
Compatibility of 5-fluorouracil and total nutrition solutions.
JPEN 1982 ; 6: 163-165.
1410 εφημερίδα Trissel LA, Martinez JF, Simmons M.
Compatibility of etoposide phosphate with selected drugs during simulated Y-site injection.
J Am Pharm Assoc 1999 ; 39: 141-145.
1415 εφημερίδα Trissel L.A, Gilbert D.L, Martinez J.F, Baker M.B, Walter W.V, Mirtallo J.M.
Compatibility of medications with 3-in-1 parenteral nutrition admixtures.
JPEN 1999 ; 23: 67-74.
1423 εφημερίδα Trissel LA, Martinez JF, Gilbert DL.
Compatibility of gemcitabine hyrochloride with 107 selected drugs during simulated Y-site injection.
J Am Pharm Assoc 1999 ; 39: 514-518.
1475 εφημερίδα Martel P, Petit I, Pinguet F, Poujol S, Astre C, Fabbro M.
Long-term stability of 5-fluorouracil stored in PVC bags and in ambulatory pump reservoirs.
J Pharm Biomed Anal 1996 ; 14: 395-399.
1501 εφημερίδα Beitz C, Bertsch T, Hannak D, Schrammel W, Einberger C, Wehling M.
Compatibility of plastics with cytotoxic drug solutions - comparison of polyethylene with other container materials.
Int J Pharm 1999 ; 185: 113-121.
1520 Εργαστήριο Etude de stabilité des médicaments en Ecoflac®
B Braun 2001
1625 εφημερίδα Trissel LA, Saenz C, Williams YW, Ingram D.
Incompatibilities of lansoprazole injection with other drugs during simulated Y-site coadministration.
Int J Pharm Compound 2001 ; 5: 314-321.
1812 εφημερίδα Fuhrman LC, Godwin DA, Davis RA.
Stability of 5-fluorouracil in an extemporaneously compounded ophtalmic solution.
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1817 εφημερίδα Roberts S, Sewell GJ.
Stability and compatibility of 5-fluorouracil infusions in the Braun Easypump®.
J Oncol Pharm Practice 2003 ; 9: 109-112.
1842 εφημερίδα Sadjack A, Wintersteiger R.
Compatibility of morphin, baclofen, floxuridine and fluorouracil in an implantable infusion pump.
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1925 εφημερίδα Trissel LA , Williams KY, Gilbert DL.
Compatibility screening of linezolid injection during simulated Y-site administration with other drugs and infusion solutions.
J Am Pharm Assoc 2000 ; 40: 515-519.
1953 εφημερίδα Trissel LA, Saenz CA, Ogundele AB, Ingram DS.
Physical compatibility of pemetrexed disodium with other drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2004 ; 61: 2289-2293.
1982 εφημερίδα Trissel LA, Ogundele AB.
Compatibility of anidulafungin with other drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2005 ; 62: 834-837.
1998 εφημερίδα Allwood MC.
Fluorouracil precipitate.
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2009 εφημερίδα Trissel LA, Zhang Y.
Physical and chemical stability of palonosetron hydrochloride with fluorouracil and with gemcitabine hydrochloride during simulated Y-site administration.
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2130 εφημερίδα Lokiec F, Amirault P, Bonnans H, Gauzan MF, Sauvage N, Santoni J.
Stabilité du mélange 5-fluoro-uracil-acide fonique : influence des concentrations, du contenant et de la forme de l’acide folinique.
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2181 εφημερίδα Milano G, Renée N.
Etude de compatibilité physicochimique 5- fluoro-uracile (nouvelle préparation française) - acide folinique.
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2262 εφημερίδα Brammer MK, Chan P, Heatherly K, Trusley C, Kupiec TC, Trissel LA, Psathas PA, Gilmor T, Schaufelberger D.
Compatibility of doripenem with other drugs during simulated Y-site administratioN
Am J Health-Syst Pharm 2008 ; 65: 1261-1265.
2323 εφημερίδα Galanti L, Lebitasy M.P, Hecq J.D, Cadrobbi J, Vanbeckbergen D, Jamart J.
Long-Term Stability of 5-Fluorouracil in 0.9% Sodium Chloride after Freezing, Microwave Thawing, and Refrigeration
Can J Hosp Pharm 2009 ; 62, 1
3369 Εργαστήριο Levofolinate de sodium Medac - Résumé des caractéristiques du produits
MEDAC France 2011
3474 Εργαστήριο Fluorouracil - Summary of Product Characteristics
Accord Healthcare Limited 2009
3531 Εργαστήριο Morphine sulphate 10 mg/mL injection BP – Summary of Product Characteristics
Wockhardt 2014
3574 Εργαστήριο Ondansetron - Résumé des caractéristiques du produit
Accord Healthcare France SAS 2013
3578 Εργαστήριο Cisplatin - Summary of Product Characteristics
Accord Healthcare 2011
3580 Εργαστήριο Cytarabine Accord - Résumé des caractéristiques du produit
Accord Healthcare France 2016
3634 Εργαστήριο Oxaliplatine (Oxaliplatine Accord®) - Résumé des caractéristiques du produit
Accord Healthcare 2011
3637 Εργαστήριο Methotrexate (Methotrexate solution for injection®) - Summary of Product Characteristics
Hameln Pharmaceuticals 2014
3645 Εργαστήριο Doxorubicin - Summary of Product Characteristics
Accord Healthcare 2014
3670 εφημερίδα Sewell G, Massimini M.
Studies on the stability and compatibility of cytotoxic drug infusion with the Tevadaptor system.
EJOP 2014 ; 8, 3: 26-30.
3873 εφημερίδα Tan X, Hu J.
Incompatibility between irinotecan and fluorouracil injections
Am J Health-Syst Pharm 2016 ; 73:755.
3948 εφημερίδα Bouchoud L, Fonzo-Christe C, Klingm?ller M, Bonnabry P .
Compatibility of Intravenous Medications With Parenteral Nutrition - In Vitro Evaluation.
JPEN 2012 ;30. 416?424.
4568 εφημερίδα Closset M,Onorati S, Colsoul M.L,Goderniaux N,Bihin B, Jamart J, Soumoy L, Hecq J.D, Odou P, Galanti L.
Long-term physico-chemical stability of 5-fluorouracile at standardised rounded doses (SRD) in MyFuser® portable infusion pump.
Journal of Chemotherapy 2021
4735 εφημερίδα Closset M, Onorati S, Colsoul M-L, Goderniaux N, Bihin B, Jamart J, Soumoy L, Hecq J-D, Odou P, Galanti L.
Long-term physicochemical stability of 5-fluorouracil at selected standardised rounded doses in polyolefin bags.
J Oncol Pharm Practice 2023 ;29,8:1878 - 1883
4759 αφίσα Ma NH, Charbonneau LF, Law S, Walker S.
Stability of 5-fluorouracil at 4°C, 25°C, and 33°C stored in NiproSureFuser+ Ambulatory Balloon Infusers.
Sunnybrook Healt Science Centre 2023

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