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Analgesic   Fentanyl citrate  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Anesfent Brazil
Fendrop India
Feniject Iran
Fenodid Chile, Colombia, Mexico
Fenstud Austria
Fentamed Austria, Brazil, Germany, Italy, Spain
Fentanest Chile, Ecuador, Italy, Mexico, Portugal, Spain
Fentanex Colombia, Ecuador, Spain
Fentanyl Australia, Austria, Denmark, Germany, Luxembourg, Saudi Arabia, Tunisia
Fentax Argentina, Ecuador
Filtaten Mexico
Haldid Denmark
Lanzapin Colombia
Leptanal Iceland, Norway, Sweden
Miuron Colombia
Nafluvent Argentina, Colombia
Sintenyl Switzerland
Sublimaze Argentina, Australia, Great Britain, Ireland, New Zealand
Talgesil Malaysia
Talinat Turkey
Utranil Mexico
Stability of mixtures   injection   Stability of mixtures : Fentanyl citrate     
Container Solvent Concentration Compound Temperature Storage Duration of stability References
Glass NaCl 0,9% or Glucose 5% 25 µg/ml
injection   Fentanyl citrate   
injection   Esmolol hydrochloride 5 mg/ml
15°C-30°C
8 Hour
Light 8
Glass Sodium chloride 0,9% 3 µg/ml
injection   Fentanyl citrate   
injection   Ropivacain hydrochloride 1,5 mg/ml
2-8°C
51 Day
Protect from light 1832
Level of evidence B
Glass Sodium chloride 0,9% 3 µg/ml
injection   Fentanyl citrate   
injection   Ropivacain hydrochloride 1,5 mg/ml
20°C
51 Day
With or without light 1832
Level of evidence B
Glass Sodium chloride 0,9% 10 µg/ml
injection   Fentanyl citrate   
injection   Droperidol 0,05 mg/ml
injection   Ketamine hydrochloride 1 mg/ml
25°C
30 Day
Protect from light 1993
Glass Sodium chloride 0,9% 20 µg/ml
injection   Fentanyl citrate   
injection   Naloxone hydrochloride 0,004 mg/ml
25°C
72 Hour
Protect from light 4559
Level of evidence A
Glass Sodium chloride 0,9% 20 µg/ml
injection   Fentanyl citrate   
injection   Naloxone hydrochloride 0,004 mg/ml
4°C
72 Hour
Protect from light 4559
Level of evidence A
Glass Glucose 5% 25 µg/ml
injection   Fentanyl citrate   
injection   Milrinone lactate 0,2 mg/ml
22°C-23°C
4 Hour
Light 813
Level of evidence A
Glass Glucose 5% 20 & 40 µg/ml
injection   Fentanyl citrate   
injection   Midazolam hydrochloride 0,1 & 0,5 mg/ml
23°C-25°C
3 Hour
Light 225
Level of evidence C
Glass None 25 µg/ml
injection   Fentanyl citrate   
injection   Palonosetron hydrochloride 25 µg/ml
25°C
4 Hour
Light 2196
Level of evidence A+
Polyvinyl chloride Sodium chloride 0,9% 3 µg/ml
injection   Fentanyl citrate   
injection   Ropivacain hydrochloride 1,5 mg/ml
2-8°C
11 Day
Protect from light 1832
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 3 µg/ml
injection   Fentanyl citrate   
injection   Ropivacain hydrochloride 1,5 mg/ml
20°C
11 Day
With or without light 1832
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 20 µg/ml
injection   Fentanyl citrate   
injection   Bupivacaine hydrochloride 1,250 mg/ml
23°C
30 Day
With or without light 60
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 10 µg/ml
injection   Fentanyl citrate   
injection   Droperidol 0,05 mg/ml
injection   Ketamine hydrochloride 1 mg/ml
25°C
30 Day
Protect from light 1993
Polyvinyl chloride Sodium chloride 0,9% 20 µg/ml
injection   Fentanyl citrate   
injection   Naloxone hydrochloride 0,004 mg/ml
25°C
72 Hour
Protect from light 4559
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 2 µg/ml
injection   Fentanyl citrate   
injection   Bupivacaine hydrochloride 0,59 & 1,25 mg/ml
25°C-30°C
32 Day
Light 1723
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 1,25 µg/ml
injection   Fentanyl citrate   
injection   Bupivacaine hydrochloride 0,43 mg/ml
injection   Epinephrine hydrochloride 0,0006 µg/ml
30°C
48 Hour
Protect from light 217
Level of evidence C
Polyvinyl chloride Sodium chloride 0,9% 1,25 µg/ml
injection   Fentanyl citrate   
injection   Bupivacaine hydrochloride 0,43 mg/ml
injection   Epinephrine hydrochloride 0,0006 µg/ml
3°C
20 Day
Protect from light 217
Level of evidence C
Polyvinyl chloride Sodium chloride 0,9% 20 µg/ml
injection   Fentanyl citrate   
injection   Bupivacaine hydrochloride 1,250 mg/ml
3°C
30 Day
With or without light 60
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 2 µg/ml
injection   Fentanyl citrate   
injection   Bupivacaine hydrochloride 0,59 & 1,25 mg/ml
4-8°C
32 Day
Protect from light 1723
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 10 µg/ml
injection   Fentanyl citrate   
injection   Droperidol 0,05 mg/ml
injection   Ketamine hydrochloride 1 mg/ml
4°C
30 Day
Protect from light 1993
Polyvinyl chloride Sodium chloride 0,9% 20 µg/ml
injection   Fentanyl citrate   
injection   Naloxone hydrochloride 0,004 mg/ml
4°C
72 Hour
Protect from light 4559
Level of evidence A
Polyvinyl chloride Not specified 2 µg/ml
injection   Fentanyl citrate   
injection   Epinephrine hydrochloride 2 µg/ml
injection   Bupivacaine hydrochloride 1 mg/ml
18-22°C
184 Day
Protect from light 2306
Level of evidence B
Polyvinyl chloride Not specified 2 µg/ml
injection   Fentanyl citrate   
injection   Bupivacaine hydrochloride 1 mg/ml
18-22°C
184 Day
Protect from light 2306
Level of evidence B
Polyvinyl chloride Not specified 2 µg/ml
injection   Fentanyl citrate   
injection   Bupivacaine hydrochloride 1 mg/ml
injection   Epinephrine hydrochloride 2 µg/ml
4°C
184 Day
Protect from light 2306
Level of evidence B
Polyvinyl chloride Not specified 2 µg/ml
injection   Fentanyl citrate   
injection   Bupivacaine hydrochloride 1 mg/ml
4°C
184 Day
Protect from light 2306
Level of evidence B
Polypropylene Sodium chloride 0,9% 1 µg/ml
injection   Fentanyl citrate   
injection   Ropivacain hydrochloride 1 & 2 mg/ml
30°C
30 Day
Protect from light 1665
Polypropylene Sodium chloride 0,9% 10 µg/ml
injection   Fentanyl citrate   
injection   Ropivacain hydrochloride 2 mg/ml
30°C
30 Day
Protect from light 1665
Polypropylene None 2 µg/ml
injection   Fentanyl citrate   
injection   Epinephrine hydrochloride 2 µg/ml
injection   Bupivacaine hydrochloride 1 mg/ml
22°C
180 Day
Light 1875
Level of evidence B
Polypropylene None 2 µg/ml
injection   Fentanyl citrate   
injection   Epinephrine hydrochloride 2 µg/ml
injection   Bupivacaine hydrochloride 1 mg/ml
4°C
180 Day
Protect from light 1875
Level of evidence B
Ethylene vinyl acetate Sodium chloride 0,9% 3 µg/ml
injection   Fentanyl citrate   
injection   Ropivacain hydrochloride 1,5 mg/ml
2-8°C
51 Day
Protect from light 1832
Level of evidence B
Ethylene vinyl acetate Sodium chloride 0,9% 3 µg/ml
injection   Fentanyl citrate   
injection   Ropivacain hydrochloride 1,5 mg/ml
20°C
51 Day
With or without light 1832
Level of evidence B
Polypropylen Syringe Water for Injection 40 µg/ml
injection   Fentanyl citrate   
injection   Scopolamine N-butyl bromide 0,85 mg/ml
injection   Midazolam hydrochloride 0,6 mg/ml
32°C
10 Day
Protect from light 1405
Level of evidence B
Polypropylen Syringe Water for Injection 40 µg/ml
injection   Fentanyl citrate   
injection   Midazolam hydrochloride 0,6 mg/ml
injection   Metoclopramide hydrochloride 0,7 mg/ml
32°C
10 Day
Protect from light 1405
Level of evidence B
Polypropylen Syringe Sodium chloride 0,9% 13 & 38 µg/ml
injection   Fentanyl citrate   
injection   Midazolam hydrochloride 0,66 & 0,9 mg/ml
22°C
7 Day
Not specified 929
Level of evidence B
Polypropylen Syringe Sodium chloride 0,9% 16,7 µg/ml
injection   Fentanyl citrate   
injection   Ondansetron hydrochloride 1,33 mg/ml
23°C
24 Hour
Light 815
Level of evidence C+
Polypropylen Syringe Sodium chloride 0,9% 13 & 38 µg/ml
injection   Fentanyl citrate   
injection   Midazolam hydrochloride 0,66 & 0,9 mg/ml
38°C
4 Day
Not specified 929
Level of evidence B
Polypropylen Syringe Sodium chloride 0,9% 16,7 µg/ml
injection   Fentanyl citrate   
injection   Ondansetron hydrochloride 1,33 mg/ml
4°C
24 Hour
Protect from light 815
Level of evidence C+
Polypropylen Syringe Sodium chloride 0,9% 13 & 38 µg/ml
injection   Fentanyl citrate   
injection   Midazolam hydrochloride 0,66 & 0,9 mg/ml
5°C
7 Day
Protect from light 929
Level of evidence B
Polypropylen Syringe None 0,0024 µg/ml
injection   Fentanyl citrate   
injection   Propofol 0,0095 mg/ml
injection   Vecuronium bromide 0,127 mg/ml
22°C
1 Hour
Protect from light 1863
Polyisoprene elastomer Sodium chloride 0,9% 16 µg/ml
injection   Fentanyl citrate   
injection   Hydromorphone hydrochloride 0,08 mg/ml
injection   Nefopam 0,8 mg/ml
injection   Ramosetron 12 µg/ml
24°C
4 Day
Protect from light 4666
Level of evidence D
Polyisoprene elastomer Sodium chloride 0,9% 16 µg/ml
injection   Fentanyl citrate   
injection   Oxycodone hydrochloride 0,4 mg/ml
injection   Nefopam 0,8 mg/ml
injection   Ondansetron hydrochloride 0,32 mg/ml
24°C
4 Day
Protect from light 4666
Level of evidence D
Polyisoprene elastomer Sodium chloride 0,9% 16 µg/ml
injection   Fentanyl citrate   
injection   Oxycodone hydrochloride 0,4 mg/ml
injection   Nefopam 0,8 mg/ml
injection   Ramosetron 12 µg/ml
24°C
4 Day
Protect from light 4666
Level of evidence D
Polyisoprene elastomer Sodium chloride 0,9% 16 µg/ml
injection   Fentanyl citrate   
injection   Hydromorphone hydrochloride 0,08 mg/ml
injection   Nefopam 0,8 mg/ml
injection   Ondansetron hydrochloride 0,32 mg/ml
24°C
4 Day
Protect from light 4666
Level of evidence D
Not specified Sodium chloride 0,9% 4 µg/ml
injection   Fentanyl citrate   
injection   Levobupivacaine hydrochloride ? mg/ml
20-22 °C
40 Hour
Not specified 3507
Manufacturer's stability data
Not specified Sodium chloride 0,9% 1 µg/ml
injection   Fentanyl citrate   
injection   Ziconotide acetate 25 µg/ml
37°C
26 Day
Protect from light 2280
Level of evidence D
Not specified None 4,1 µg/ml
injection   Fentanyl citrate   
injection   Epinephrine hydrochloride 2 µg/ml
injection   Levobupivacaine hydrochloride 0,56 mg/ml
20-24°C
40 Day
Protect from light 3401
Level of evidence D
Not specified None 4,1 µg/ml
injection   Fentanyl citrate   
injection   Levobupivacaine hydrochloride 0,56 mg/ml
20-24°C
60 Day
With or without light 3401
Level of evidence D
Not specified None 4,1 µg/ml
injection   Fentanyl citrate   
injection   Epinephrine hydrochloride 2 µg/ml
injection   Levobupivacaine hydrochloride 0,56 mg/ml
20-24°C
48 Hour
Light 3401
Level of evidence D
Not specified None 4,1 µg/ml
injection   Fentanyl citrate   
injection   Epinephrine hydrochloride 2 µg/ml
injection   Levobupivacaine hydrochloride 0,56 mg/ml
4-8°C
60 Day
Protect from light 3401
Level of evidence D
Not specified None 4,1 µg/ml
injection   Fentanyl citrate   
injection   Levobupivacaine hydrochloride 0,56 mg/ml
4-8°C
60 Day
Protect from light 3401
Level of evidence D
  Mentions Légales